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Nanoparticle Technology for Delivery of Drugs Across the Blood–Brain Barrier
Abstract
The Leu-enkephalin dalargin and the Met-enkephalin kyotorphin normally do not cross the blood-brain barrier (BBB) when given systemically. To transport these neuropeptides across the BBB they were adsorbed onto the surface of poly(butylcyanoacrylate) nanoparticles (NPs) and the NPs were coated with polysorbate 80. Central analgesia was measured by the hot plate test in mice. The antidepressant amitriptyline, which normally penetrates the BBB, was used to examine the versatility of the NP method. The concentration of amitriptyline in serum and brain of mice was determined by a gas chromatographic method. Furthermore, NPs were fabricated with different stabilizers. After the adsorption of the peptides on polysorbate 85-stabilized NPs, analgesia was noted after intravenous application when NPs were not coated. The amitriptyline level was significantly enhanced in brain when the substance was adsorbed onto the NP and coated or when the particles were stabilized with polysorbate 85.
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Citations
Cited by
Biodegradable polymeric nanoparticles as drug delivery devices
Soppimath, K. S., Aminabhavi, T. M., Kulkarni, A. R., & Rudzinski, W. E. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00339-4 · Cited by 3,549
Nanoparticles – known and unknown health risks
Hoet, P. H., Brüske-Hohlfeld, I., & Salata, O. V. (2004) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-2-12 · Cited by 1,374
Nanoparticulate systems for brain delivery of drugs.
Kreuter, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00122-8 · Cited by 1,107
Nanoparticulate systems for brain delivery of drugs
Kreuter, J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.015 · Cited by 958
Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier.
Kreuter, J., Shamenkov, D., Petrov, V., Ramge, P., Cychutek, K., Koch-Brandt, C., & Alyautdin, R. (2002) · Journal of drug targeting · doi:10.1080/10611860290031877 · Cited by 801
Metadata
- Authors
- Schroeder, U., Sommerfeld, P., Ulrich, S., & Sabel, B. A.
- Venue
- Journal of Pharmaceutical Sciences
- Publisher
- American Geophysical Union (AGU)
- Published
- 1998-11
- Volume
- 87
- Issue
- 11
- Pages
- 1305-1307
- ISSN
- 0022-3549 (ISSN-L)
- OpenAlex
- W2053202725
- Cited by
- 275
- References
- 0
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schroeder, U., Sommerfeld, P., Ulrich, S., & Sabel, B. A. (1998). Nanoparticle Technology for Delivery of Drugs Across the Blood–Brain Barrier. Journal of Pharmaceutical Sciences. https://doi.org/10.1021/js980084y
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