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A New Model Describing the Swelling and Drug Release Kinetics from Hydroxypropyl Methylcellulose Tablets
Abstract
A novel mathematical model for the water transport into and drug release from hydroxypropyl methylcellulose (HPMC) tablets is presented. Fick's second law of diffusion is used to describe the mass transfer processes in the three-component system drug/polymer/water. Numerical solutions of the respective set of partial differential equations are provided, considering axial and radial diffusion within cylindrical tablets. It is shown that the diffusion coefficients strongly depend on the water concentration (parameters quantifying this dependence have been determined). Swelling of the device is considered using moving boundary conditions, whereas dissolution processes are neglected. Experiments proved the applicability of the theory. The practical benefit of the new model is to calculate the required shape and dimensions of HPMC tablets to achieve a desired release profile.
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Citations
Cited by
Hydrogels in controlled release formulations: Network design and mathematical modeling
Lin, C.-C., & Metters, A. T. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.004 · Cited by 1,768
Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC)
Siepmann, J., & Peppas, N. A. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.028 · Cited by 1,021
Self-citationEffect of geometry on drug release from 3D printed tablets
Goyanes, A., Robles Martinez, P., Buanz, A., Basit, A. W., & Gaisford, S. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.04.069 · Cited by 667
Faisant, N., Siepmann, J., & Benoit, J. P. (2002) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(02)00023-4 · Cited by 346
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Metadata
- Authors
- Siepmann, J., Podual, K., Sriwongjanya, M., Peppas, N. A., & Bodmeier, R.
- Venue
- Journal of Pharmaceutical Sciences
- Publisher
- American Geophysical Union (AGU)
- Published
- 1999-01
- Volume
- 88
- Issue
- 1
- Pages
- 65-72
- ISSN
- 0022-3549 (ISSN-L)
- OpenAlex
- W1981215463
- Cited by
- 188
- References
- 0
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A New Model Describing the Swelling and Drug Release Kinetics from Hydroxypropyl Methylcellulose Tablets. https://app.cochat.ai/papers/10.1021/js9802291
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- Siepmann, J., Podual, K., Sriwongjanya, M., Peppas, N. A., & Bodmeier, R. (1999). A New Model Describing the Swelling and Drug Release Kinetics from Hydroxypropyl Methylcellulose Tablets. Journal of Pharmaceutical Sciences. https://doi.org/10.1021/js9802291
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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