The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Effect of geometry on drug release from 3D printed tablets
Open accessAbstract
The aim of this work was to explore the feasibility of combining hot melt extrusion (HME) with 3D printing (3DP) technology, with a view to producing different shaped tablets which would be otherwise difficult to produce using traditional methods. A filament extruder was used to obtain approx. 4% paracetamol loaded filaments of polyvinyl alcohol with characteristics suitable for use in fused-deposition modelling 3DP. Five different tablet geometries were successfully 3D-printed-cube, pyramid, cylinder, sphere and torus. The printing process did not affect the stability of the drug. Drug release from the tablets was not dependent on the surface area but instead on surface area to volume ratio, indicating the influence that geometrical shape has on drug release. An erosion-mediated process controlled drug release. This work has demonstrated the potential of 3DP to manufacture tablet shapes of different geometries, many of which would be challenging to manufacture by powder compaction.
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Cites
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Crowley, M. M., Zhang, F., Repka, M. A., Thumma, S., Upadhye, S. B., Kumar Battu, S., McGinity, J. W., & Martin, C. (2007) · Drug Development and Industrial Pharmacy · doi:10.1080/03639040701498759 · Cited by 824
Melt extrusion: from process to drug delivery technology
Breitenbach, J. (2002) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(02)00061-9 · Cited by 742
Fused-filament 3D printing (3DP) for fabrication of tablets
Goyanes, A., Buanz, A. B. M., Basit, A. W., & Gaisford, S. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.09.044 · Cited by 587
Self-citation3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets
Goyanes, A., Buanz, A. B. M., Hatton, G. B., Gaisford, S., & Basit, A. W. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.12.003 · Cited by 570
Self-citationSkowyra, J., Pietrzak, K., & Alhnan, M. A. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.11.009 · Cited by 530
Expandable gastroretentive dosage forms
Klausner, E. A., Lavy, E., Friedman, M., & Hoffman, A. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00203-7 · Cited by 419
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Towards fabrication of 3D printed medical devices to prevent biofilm formation
Sandler, N., Salmela, I., Fallarero, A., Rosling, A., Khajeheian, M., Kolakovic, R., Genina, N., Nyman, J., & Vuorela, P. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.11.001 · Cited by 184
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Real-time assessment of critical quality attributes of a continuous granulation process
Fonteyne, M., Vercruysse, J., Córdoba-Díaz, D., Gildemyn, D., Vervaet, C., Remon, J. P., & Beer, T. D. (2011) · Pharmaceutical Development and Technology · doi:10.3109/10837450.2011.627869 · Cited by 127
Cited by
Additive manufacturing (3D printing): A review of materials, methods, applications and challenges
Ngo, T. D., Kashani, A., Imbalzano, G., Nguyen, K. T. Q., & Hui, D. (2018) · Composites Part B: Engineering · doi:10.1016/j.compositesb.2018.02.012 · Cited by 8,431
Selective laser sintering (SLS) 3D printing of medicines
Fina, F., Goyanes, A., Gaisford, S., & Basit, A. W. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.06.082 · Cited by 577
Self-citationEmergence of 3D Printed Dosage Forms: Opportunities and Challenges
Alhnan, M. A., Okwuosa, T. C., Sadia, M., Wan, K.-W., Ahmed, W., & Arafat, B. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1933-1 · Cited by 554
Additive Manufacturing of Biomaterials, Tissues, and Organs
Zadpoor, A. A., & Malda, J. (2017) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1719-y · Cited by 462
Fused filament fabrication of polymer materials: A review of interlayer bond
Gao, X., Qi, S., Kuang, X., Su, Y., Li, J., & Wang, D. (2021) · Additive Manufacturing · doi:10.1016/j.addma.2020.101658 · Cited by 418
Metadata
- Authors
- Goyanes, A., Robles Martinez, P., Buanz, A., Basit, A. W., & Gaisford, S.
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 494
- Issue
- 2
- Pages
- 657-663
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2002062356
- Cited by
- 667
- References
- 14
- FWCI
- 51.90
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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