The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Solid‐state chemical stability of proteins and peptides
Abstract
Peptide and protein drugs are often formulated in the solid-state to provide stabilization during storage. However, reactions can occur in the solid-state, leading to degradation and inactivation of these agents. This review summarizes the major chemical reactions affecting proteins and peptides in the solid-state: deamidation, peptide bond cleavage, oxidation, the Maillard reaction, beta-elimination, and dimerization/aggregation. Physical and chemical factors influencing these reactions are also discussed. These include temperature, moisture content, excipients, and the physical state of the formulation (amorphous vs crystalline). The review is intended to serve as an aid for those involved in formulation, and to stimulate further research on the determinants of peptide and protein reactivity in the solid-state.
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Cites
Introduction to Physical Polymer Science
Sperling, L. H. (2005) · doi:10.1002/0471757128 · Cited by 2,917
Cited by
Bilati, U., Allémann, E., & Doelker, E. (2005) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.10.006 · Cited by 313
Quintana, D. S., Guastella, A. J., Westlye, L. T., & Andreassen, O. A. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.166 · Cited by 107
Farrugia, J. M., O’Hair, R. A. J., & Reid, G. E. (2001) · International Journal of Mass Spectrometry · doi:10.1016/s1387-3806(01)00421-3 · Cited by 103
Metadata
- Authors
- Lai, M. C., & Topp, E. M.
- Venue
- Journal of Pharmaceutical Sciences
- Publisher
- American Geophysical Union (AGU)
- Published
- 1999-05
- Volume
- 88
- Issue
- 5
- Pages
- 489-500
- ISSN
- 0022-3549 (ISSN-L)
- OpenAlex
- W1981000246
- Cited by
- 285
- References
- 1
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Solid‐state chemical stability of proteins and peptides. https://app.cochat.ai/papers/10.1021/js980374e
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- Lai, M. C., & Topp, E. M. (1999). Solid‐state chemical stability of proteins and peptides. Journal of Pharmaceutical Sciences. https://doi.org/10.1021/js980374e
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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