The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Studies on the Drug Release Properties of Polysaccharide Multilayers Encapsulated Ibuprofen Microparticles
Abstract
Ibuprofen microcrystals sized between 5 and 40 μm have been encapsulated with polyelectrolyte multilayers (PEM) for the purpose of controlled release. The encapsulation was accomplished by a novel coating technology based on layer-by-layer assembly of oppositely charged polyelectrolytes. The biocompatible polyelectrolytes including chitosan, dextran sulfate, carboxymethyl cellulose, and sodium alginate were used as coating materials to fabricate PEM capsules with varying shell thicknesses from 20 to 60 nm. UV spectroscopy was employed to monitor the drug release processes in both pH 1.4 and pH 7.4 solutions. It was found that the release of ibuprofen from these microcapsules is dependent on several parameters such as the crystal size, the PEM capsule thickness, and the solubility of the core material in the bulk solutions. Our results reveal that the polysaccharide capsules can substantially prolong the release time of the encapsulated drug crystals.
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Citations
Cites
Polymeric systems for controlled drug release
Uhrich, K. E., Cannizzaro, S. M., Langer, R. S., & Shakesheff, K. M. (1999) · Chemical Reviews · doi:10.1021/cr940351u · Cited by 2,633
Cited by
Ariga, K., Hill, J. P., & Ji, Q. (2007) · Physical Chemistry Chemical Physics · doi:10.1039/b700410a · Cited by 1,256
Zhu, Y., Shi, J., Shen, W., Dong, X., Feng, J., Ruan, M., & Li, Y. (2005) · Angewandte Chemie · doi:10.1002/ange.200501500 · Cited by 270
Wang, Q., & Zhang Newby, B.-M. (2018) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.04.019 · Cited by 30
Metadata
- Authors
- Qiu, X., Leporatti, S., Donath, E., & Möhwald, H.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2001-07-21
- Volume
- 17
- Issue
- 17
- Pages
- 5375-5380
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2088159992
- Cited by
- 415
- References
- 1
- FWCI
- 14.63
- Type
- journal article
- Language
- en
- Open access
- closed
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