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Controlled Synthesis of Nonspherical Microparticles Using Microfluidics
Abstract
The controlled synthesis of nonspherical microparticles using microfluidics processing is described. Polymer droplets, formed by shearing a photopolymer using a continuous water phase at a T-junction, were constrained to adopt nonspherical shapes by confining them using appropriate microchannel geometries. Plugs were obtained by shearing the polymer phase at low shear rates, while disks were obtained by flattening droplets using a channel of low height. The nonspherical shapes formed were permanently preserved by photopolymerizing the constrained droplets in situ using ultraviolet light. Monodisperse plugs and disks of different lengths and diameters were obtained by varying the flow rates of the two phases.
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Citations
Cited by
Teh, S.-Y., Lin, R., Hung, L.-H., & Lee, A. P. (2008) · Lab on a Chip · doi:10.1039/b715524g · Cited by 2,690
Formation of droplets and bubbles in a microfluidic T-junction—scaling and mechanism of break-up
Garstecki, P., Fuerstman, M. J., Stone, H. A., & Whitesides, G. M. (2006) · Lab on a Chip · doi:10.1039/b510841a · Cited by 2,339
25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Annabi, N., Tamayol, A., Uquillas, J. A., Akbari, M., Bertassoni, L. E., Cha, C., Camci‐Unal, G., Dokmeci, M. R., Peppas, N. A., & Khademhosseini, A. (2014) · Advanced Materials · doi:10.1002/adma.201303233 · Cited by 1,409
Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers
Champion, J. A., Katare, Y. K., & Mitragotri, S. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.03.022 · Cited by 1,206
Multiphase microfluidics: from flow characteristics to chemical and materials synthesis
Günther, A., & Jensen, K. F. (2006) · Lab Chip · doi:10.1039/b609851g · Cited by 983
Metadata
- Authors
- Dendukuri, D., Tsoi, K., Hatton, T. A., & Doyle, P. S.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-02-11
- Volume
- 21
- Issue
- 6
- Pages
- 2113-2116
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2019646543
- Cited by
- 482
- References
- 0
- FWCI
- 22.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dendukuri, D., Tsoi, K., Hatton, T. A., & Doyle, P. S. (2005). Controlled Synthesis of Nonspherical Microparticles Using Microfluidics. Langmuir. https://doi.org/10.1021/la047368k
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
