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Structure and Function of Enzymes Adsorbed onto Single-Walled Carbon Nanotubes
Abstract
We have examined the structure and function of two enzymes, alpha-chymotrypsin (CT) and soybean peroxidase (SBP), adsorbed onto single-walled carbon nanotubes (SWNTs). SBP retained up to 30% of its native activity upon adsorption, while the adsorbed CT retained only 1% of its native activity. Analysis of the secondary structure of the proteins via FT-IR spectroscopy revealed that both enzymes undergo structural changes upon adsorption, with substantial secondary structural perturbation observed for CT. Consistent with these results, AFM images of the adsorbed enzymes indicated that SBP retains its native three-dimensional shape while CT appears to unfold on the SWNT surface. This study represents the first in depth investigation of protein structure and function on carbon nanotubes, which is critical in designing optimal carbon nanotube-protein conjugates.
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Cites
Protein secondary structures in water from second-derivative amide I infrared spectra
Dong, A., Huang, P., & Caughey, W. S. (1990) · Biochemistry · doi:10.1021/bi00465a022 · Cited by 1,333
Cited by
Aggarwal, P., Hall, J. B., McLeland, C. B., Dobrovolskaia, M. A., & McNeil, S. E. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.009 · Cited by 1,791
Methods for stabilizing and activating enzymes in ionic liquids—a review
Zhao, H. (2010) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.2375 · Cited by 351
Differential plasma protein binding to metal oxide nanoparticles
Deng, Z. J., Mortimer, G., Schiller, T., Musumeci, A., Martin, D., & Minchin, R. F. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/45/455101 · Cited by 337
Advancement in carbon nanotubes: basics, biomedical applications and toxicity
Beg, S., Rizwan, M., Sheikh, A. M., Hasnain, M. S., Anwer, K., & Kohli, K. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2010.01167.x · Cited by 306
Physico-chemical features of engineered nanoparticles relevant to their toxicity
Fubini, B., Ghiazza, M., & Fenoglio, I. (2010) · Nanotoxicology · doi:10.3109/17435390.2010.509519 · Cited by 297
Metadata
- Authors
- Karajanagi, S. S., Vertegel, A. A., Kane, R. S., & Dordick, J. S.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-11-16
- Volume
- 20
- Issue
- 26
- Pages
- 11594-11599
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2011416230
- Cited by
- 508
- References
- 1
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- closed
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