Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy
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Proteins bind the surfaces of nanoparticles, and biological materials in general, immediately upon introduction of the materials into a physiological environment. The further biological response of the body is influenced by the nanoparticle-protein complex. The nanoparticle's composition and surface chemistry dictate the extent and specificity of protein binding. Protein binding is one of the key elements that affects biodistribution of the nanoparticles throughout the body. Here we review recent research on nanoparticle physicochemical properties important for protein binding, techniques for isolation and identification of nanoparticle-bound proteins, and how these proteins can influence particle biodistribution and biocompatibility. Understanding the nanoparticle-protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution.
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Properties such as size, surface charge, hydrophobicity/hydrophilicity, and steric effects of particle coating influence compatibility of nanoparticles with immune system.
“Additionally, the properties such as size, surface charge, hydrophobicity/hydrophilicity, and the steric effects of particle coating have influence on the compatibility of nanoparticles with the immune system [147–150].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [150]
Formation of specific antibodies against nanoparticles may affect efficacy and safety of nanoparticle-based therapeutics.
“It is worth noting that formation of specific antibodies against nanoparticles may affect the efficacy and the safety of nanoparticle-based therapeutics [149, 150].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [150]
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- Authors
- Aggarwal, P., Hall, J. B., McLeland, C. B., Dobrovolskaia, M. A., & McNeil, S. E.
- Affiliations
- Science Applications International Corporation (United States) (US)
- Corresponding author
- Dobrovolskaia, Marina A.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 61
- Issue
- 6
- Pages
- 428-437
- ISSN
- 0169-409X (ISSN-L)
- PMC
- PMC3683962
- OpenAlex
- W2021876818
- Cited by
- 1,791
- References
- 139
- Citations by year
- 2026: 42 · 2025: 72 · 2024: 73 · 2023: 80 · 2022: 111 · 2021: 129 · 2020: 148 · 2019: 145 · 2018: 129 · 2017: 137 · 2016: 158 · 2015: 137 · 2014: 133 · 2013: 103 · 2012: 85
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01co12400-79-0-22, HHSN261200800001C)
- National Cancer Institute (N01CO12400, N01-CO-012400, HHSN261200800001E))
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Keywords
- protein-nanoparticle binding, plasma proteins, nanoparticle biodistribution, biocompatibility, nanoparticle surface chemistry, nanoparticle physicochemical properties, protein binding specificity, bioavailability, treatment efficacy
- MeSH terms
- Animals, Blood Proteins, Drug Carriers, Humans, Kinetics, Protein Binding, Tissue Distribution, Nanoparticles
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