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Phosphonic Acid Monolayers for Binding of Bioactive Molecules to Titanium Surfaces
Open accessAbstract
Two different phosphonic acid monolayer films for immobilization of bioactive molecules such as the protein BMP-2 on titanium surfaces have been prepared. Monolayers of (11-hydroxyundecyl)phosphonic acid and (12-carboxydodecyl)phosphonic acid molecules were produced by a simple dipping process (the T-BAG method). The terminal functional groups on these monolayers were activated (carbonyldiimidazole for hydroxyl groups and N-hydroxysuccinimide for carboxyl groups) to bind amine-containing molecules. The reactivity of the surfaces was investigated using trifluoroethylamine hydrochloride and BMP-2. Each step of the surface modification procedure was characterized by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry.
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Metadata
- Authors
- Adden, N., Gamble, L. J., Castner, D. G., Hoffmann, A., Gross, G., & Menzel, H.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-08-18
- Volume
- 22
- Issue
- 19
- Pages
- 8197-8204
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W1994984182
- Cited by
- 265
- References
- 20
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- green
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