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pH-Dependent Protein Conformational Changes in Albumin:Gold Nanoparticle Bioconjugates: A Spectroscopic Study
Abstract
The conformational changes of bovine serum albumin (BSA) in the albumin:gold nanoparticle bioconjugates were investigated in detail by various spectroscopic techniques including UV-vis absorption, fluorescence, circular dichroism, and Fourier transform infrared spectroscopies. Our studies suggested that albumin in the bioconjugates that was prepared by the common adsorption method underwent substantial conformational changes at both secondary and tertiary structure levels. BSA was found to adopt a more flexible conformational state on the boundary surface of gold nanoparticles as a result of the conformational changes in the bioconjugates. The conformational changes at pH 3.8, 7.0, and 9.0, which corresponded to different isomeric forms of albumin, were investigated, respectively, to probe the pH effect on the conformational changes of BSA in the bioconjugates. The results showed that the pH of the medium influenced the changes greatly and that fluorescence and circular dichroism studies further indicated that the changes were larger at higher pH.
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Cited by
Sapsford, K. E., Tyner, K. M., Dair, B. J., Deschamps, J. R., & Medintz, I. L. (2011) · Analytical Chemistry · doi:10.1021/ac200853a · Cited by 538
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Guo, Y., Bao, Y.-H., Sun, K.-F., Chang, C., & Liu, W.-F. (2021) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2020.106293 · Cited by 223
Foroozandeh, P., & Aziz, A. A. (2015) · Nanoscale Research Letters · doi:10.1186/s11671-015-0922-3 · Cited by 143
Metadata
- Authors
- Shang, L., Wang, Y., Jiang, J., & Dong, S.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-01-24
- Volume
- 23
- Issue
- 5
- Pages
- 2714-2721
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W1990379353
- Cited by
- 557
- References
- 0
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shang, L., Wang, Y., Jiang, J., & Dong, S. (2007). pH-Dependent Protein Conformational Changes in Albumin:Gold Nanoparticle Bioconjugates: A Spectroscopic Study. Langmuir. https://doi.org/10.1021/la062064e
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