The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Lateral Dimension-Dependent Antibacterial Activity of Graphene Oxide Sheets
Abstract
Graphene oxide (GO) is a promising precursor to produce graphene-family nanomaterials for various applications. Their potential health and environmental impacts need a good understanding of their cellular interactions. Many factors may influence their biological interactions with cells, and the lateral dimension of GO sheets is one of the most relevant material properties. In this study, a model bacterium, Escherichia coli ( E. coli ), was used to evaluate the antibacterial activity of well-dispersed GO sheets, whose lateral size differs by more than 100 times. Our results show that the antibacterial activity of GO sheets toward E. coli cells is lateral size dependent. Larger GO sheets show stronger antibacterial activity than do smaller ones, and they have different time- and concentration-dependent antibacterial activities. Large GO sheets lead to most cell loss after 1 h incubation, and their concentration strongly influences antibacterial activity at relative low concentration (<10 μg/mL). In contrast, when incubating with small GO sheets up to 4 h, the inactivation rate of E. coli cells continues increasing. The increase of small GO sheet concentration also results in persistent increases in their antibacterial activity. In this study, GO sheets with different lateral sizes are all well dispersed, and their oxidation capacity toward glutathione is similar, consistent with X-ray photoelectron spectroscopy and ultraviolet-visible absorption spectroscopy results. This suggests the lateral size-dependent antibacterial activity of GO sheets is caused by neither their aggregation states, nor oxidation capacity. Atomic force microscope analysis of GO sheets and cells shows that GO sheets interact strongly with cells. Large GO sheets more easily cover cells, and cells cannot proliferate once fully covered, resulting in the cell viability loss observed in the followed colony counting test. In contrast, small GO sheets adhere to the bacterial surfaces, which cannot effectively isolate cells from environment. This study highlights the importance of tailoring the lateral dimension of GO sheets to optimize the application potential with minimal risks for environmental health and safety.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Geim, A. K., & Novoselov, K. S. (2007) · Nature Materials · doi:10.1038/nmat1849 · Cited by 39,979
Preparation of Graphitic Oxide
Hummers, W. S., & Offeman, R. E. (1958) · Journal of the American Chemical Society · doi:10.1021/ja01539a017 · Cited by 29,920
The chemistry of graphene oxide
Dreyer, D. R., Park, S., Bielawski, C. W., & Ruoff, R. S. (2010) · Chem. Soc. Rev. · doi:10.1039/b917103g · Cited by 11,653
Graphene and Graphene Oxide: Synthesis, Properties, and Applications
Zhu, Y., Murali, S., Cai, W., Li, X., Suk, J. W., Potts, J. R., & Ruoff, R. S. (2010) · Advanced Materials · doi:10.1002/adma.201001068 · Cited by 10,522
Processable aqueous dispersions of graphene nanosheets
Li, D., Müller, M. B., Gilje, S., Kaner, R. B., & Wallace, G. G. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2007.451 · Cited by 9,114
Chemical methods for the production of graphenes
Park, S., & Ruoff, R. S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.58 · Cited by 6,663
Preparation and characterization of graphene oxide paper
Dikin, D. A., Stankovich, S., Zimney, E. J., Piner, R. D., Dommett, G. H. B., Evmenenko, G., Nguyen, S. T., & Ruoff, R. S. (2007) · Nature · doi:10.1038/nature06016 · Cited by 5,594
Kovtyukhova, N. I., Ollivier, P. J., Martin, B. R., Mallouk, T. E., Chizhik, S. A., Buzaneva, E. V., & Gorchinskiy, A. D. (1999) · Chemistry of Materials · doi:10.1021/cm981085u · Cited by 3,240
Liu, S., Zeng, T. H., Hofmann, M., Burcombe, E., Wei, J., Jiang, R., Kong, J., & Chen, Y. (2011) · ACS Nano · doi:10.1021/nn202451x · Cited by 2,929
Self-citationImpermeable Atomic Membranes from Graphene Sheets
Bunch, J. S., Verbridge, S. S., Alden, J. S., van der Zande, A. M., Parpia, J. M., Craighead, H. G., & McEuen, P. L. (2008) · Nano Letters · doi:10.1021/nl801457b · Cited by 2,919
Compton, O. C., & Nguyen, S. T. (2010) · Small · doi:10.1002/smll.200901934 · Cited by 2,858
Graphene Oxide Dispersions in Organic Solvents
Paredes, J. I., Villar-Rodil, S., Martínez-Alonso, A., & Tascón, J. M. D. (2008) · Langmuir · doi:10.1021/la801744a · Cited by 2,804
Poland, C. A., Duffin, R., Kinloch, I., Maynard, A., Wallace, W. A. H., Seaton, A., Stone, V., Brown, S., MacNee, W., & Donaldson, K. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.111 · Cited by 2,645
Toxicity of Graphene and Graphene Oxide Nanowalls Against Bacteria
Akhavan, O., & Ghaderi, E. (2010) · ACS Nano · doi:10.1021/nn101390x · Cited by 2,606
Graphene-Based Antibacterial Paper
Hu, W., Peng, C., Luo, W., Lv, M., Li, X., Li, D., Huang, Q., & Fan, C. (2010) · ACS Nano · doi:10.1021/nn101097v · Cited by 2,003
A Chemical Route to Graphene for Device Applications
Gilje, S., Han, S., Wang, M., Wang, K. L., & Kaner, R. B. (2007) · Nano Letters · doi:10.1021/nl0717715 · Cited by 1,966
Graphene Oxide Sheets at Interfaces
Kim, J., Cote, L. J., Kim, F., Yuan, W., Shull, K. R., & Huang, J. (2010) · Journal of the American Chemical Society · doi:10.1021/ja102777p · Cited by 1,762
Langmuir−Blodgett Assembly of Graphite Oxide Single Layers
Cote, L. J., Kim, F., & Huang, J. (2009) · Journal of the American Chemical Society · doi:10.1021/ja806262m · Cited by 1,750
Colloidal Suspensions of Highly Reduced Graphene Oxide in a Wide Variety of Organic Solvents
Park, S., An, J., Jung, I., Piner, R. D., An, S. J., Li, X., Velamakanni, A., & Ruoff, R. S. (2009) · Nano Letters · doi:10.1021/nl803798y · Cited by 1,647
Graphene and graphene oxide: biofunctionalization and applications in biotechnology
Wang, Y., Li, Z., Wang, J., Li, J., & Lin, Y. (2011) · Trends in Biotechnology · doi:10.1016/j.tibtech.2011.01.008 · Cited by 1,476
Li, D., & Kaner, R. B. (2008) · Science · doi:10.1126/science.1158180 · Cited by 1,453
Recent advances in graphene-based biosensors
Kuila, T., Bose, S., Khanra, P., Mishra, A. K., Kim, N. H., & Lee, J. H. (2011) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2011.05.039 · Cited by 1,329
Biological Interactions of Graphene-Family Nanomaterials: An Interdisciplinary Review
Sanchez, V. C., Jachak, A., Hurt, R. H., & Kane, A. B. (2012) · Chemical Research in Toxicology · doi:10.1021/tx200339h · Cited by 1,263
Atomic and Electronic Structure of Graphene-Oxide
Mkhoyan, K. A., Contryman, A. W., Silcox, J., Stewart, D. A., Eda, G., Mattevi, C., Miller, S., & Chhowalla, M. (2009) · Nano Letters · doi:10.1021/nl8034256 · Cited by 1,187
Antibacterial Effects of Carbon Nanotubes: Size Does Matter!
Kang, S., Herzberg, M., Rodrigues, D. F., & Elimelech, M. (2008) · Langmuir · doi:10.1021/la800951v · Cited by 1,182
Akhavan, O., & Ghaderi, E. (2009) · The Journal of Physical Chemistry C · doi:10.1021/jp906325q · Cited by 959
Graphene in Biomedicine: Opportunities and Challenges
Feng, L., & Liu, Z. (2011) · Nanomedicine · doi:10.2217/nnm.10.158 · Cited by 716
Graphene Oxide: A Nonspecific Enhancer of Cellular Growth
Ruiz, O. N., Fernando, K. A. S., Wang, B., Brown, N. A., Luo, P. G., McNamara, N. D., Vangsness, M., Sun, Y.-P., & Bunker, C. E. (2011) · ACS Nano · doi:10.1021/nn202699t · Cited by 682
Graphene Oxide: Surface Activity and Two‐Dimensional Assembly
Kim, F., Cote, L. J., & Huang, J. (2010) · Advanced Materials · doi:10.1002/adma.200903932 · Cited by 674
Akhavan, O., Ghaderi, E., & Esfandiar, A. (2011) · The Journal of Physical Chemistry B · doi:10.1021/jp200686k · Cited by 669
Liu, S., Wei, L., Hao, L., Fang, N., Chang, M. W., Xu, R., Yang, Y., & Chen, Y. (2009) · ACS Nano · doi:10.1021/nn901252r · Cited by 567
Self-citationElectronic-Structure-Dependent Bacterial Cytotoxicity of Single-Walled Carbon Nanotubes
Vecitis, C. D., Zodrow, K. R., Kang, S., & Elimelech, M. (2010) · ACS Nano · doi:10.1021/nn101558x · Cited by 521
Das, M. R., Sarma, R. K., Saikia, R., Kale, V. S., Shelke, M. V., & Sengupta, P. (2011) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2010.10.033 · Cited by 472
Bao, Q., Zhang, D., & Qi, P. (2011) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2011.05.009 · Cited by 465
Preparation, characterization and antibacterial properties of silver-modified graphene oxide
Ma, J., Zhang, J., Xiong, Z., Yong, Y., & Zhao, X. S. (2011) · J. Mater. Chem. · doi:10.1039/c0jm02806a · Cited by 453
Physicochemical Determinants of Multiwalled Carbon Nanotube Bacterial Cytotoxicity
Kang, S., Mauter, M. S., & Elimelech, M. (2008) · Environmental Science & Technology · doi:10.1021/es8010173 · Cited by 389
Biocompatible, Robust Free‐Standing Paper Composed of a TWEEN/Graphene Composite
Park, S., Mohanty, N., Suk, J. W., Nagaraja, A., An, J., Piner, R. D., Cai, W., Dreyer, D. R., Berry, V., & Ruoff, R. S. (2010) · Advanced Materials · doi:10.1002/adma.200903611 · Cited by 382
Facile synthesis of silver@graphene oxide nanocomposites and their enhanced antibacterial properties
Xu, W.-P., Zhang, L.-C., Li, J.-P., Lu, Y., Li, H.-H., Ma, Y.-N., Wang, W.-D., & Yu, S.-H. (2011) · Journal of Materials Chemistry · doi:10.1039/c0jm03376f · Cited by 343
Inactivation of Bacterial Pathogens by Carbon Nanotubes in Suspensions
Arias, L., & Yang, L. (2009) · Langmuir · doi:10.1021/la802769m · Cited by 321
Graphene and Related Materials in Electrochemical Sensing
Ratinac, K. R., Yang, W., Gooding, J. J., Thordarson, P., & Braet, F. (2011) · Electroanalysis · doi:10.1002/elan.201000545 · Cited by 273
Brown, D. M., Kinloch, I. A., Bangert, U., Windle, A. H., Walter, D. M., Walker, G. S., Scotchford, C. A., Donaldson, K., & Stone, V. (2007) · Carbon · doi:10.1016/j.carbon.2007.05.011 · Cited by 271
Antimicrobial graphene polymer (PVK-GO) nanocomposite films
Santos, C. M., Tria, M. C. R., Vergara, R. A. M. V., Ahmed, F., Advíncula, R. C., & Rodrigues, D. F. (2011) · Chemical Communications · doi:10.1039/c1cc11877c · Cited by 179
Liu, S., Ng, A. K., Xu, R., Wei, J., Tan, C. M., Yang, Y., & Chen, Y. (2010) · Nanoscale · doi:10.1039/c0nr00441c · Cited by 174
Self-citationSreenivasan, S. T., Maliyekkal, M. S., Deepti, K., et al. (2011) · ACS Applied Materials & Interfaces · doi:10.1021/am200447p · Cited by 124
Diameter Effects on Cytotoxicity of Multi-Walled Carbon Nanotubes
Wang, X., Jia, G., Wang, H., Nie, H., Yan, L., Deng, X., & Wang, S. (2009) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2009.025 · Cited by 73
Teixeira, P., Azeredo, J., de Oliveira, R. P. S., & Chibowski, E. (1998) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(98)00065-4 · Cited by 28
Cited by
Nanotoxicity of Graphene and Graphene Oxide
Seabra, A. B., Paula, A. J., de Lima, R., Alves, O. L., & Durán, N. (2014) · Chemical Research in Toxicology · doi:10.1021/tx400385x · Cited by 893
Graphene-based nanomaterials for drug and/or gene delivery, bioimaging, and tissue engineering
Zhao, H., Ding, R., Zhao, X., Li, Y., Qu, L., Pei, H., Yildirimer, L., Wu, Z., & Zhang, W. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.04.002 · Cited by 336
Metadata
- Authors
- Liu, S., Hu, M., Zeng, T. H., Wu, R., Jiang, R., Wei, J., Wang, L., Kong, J., & Chen, Y.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-08-06
- Volume
- 28
- Issue
- 33
- Pages
- 12364-12372
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2170394629
- Cited by
- 587
- References
- 46
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
