The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Poly-2-methyl-2-oxazoline: A Peptide-like Polymer for Protein-Repellent Surfaces
Abstract
Surface coatings with so-called protein-repellent or nonfouling polymers have become indispensable for the development of modern therapeutic and diagnostic medical devices such as biosensors, drug-delivery capsules, and biomedical implants. Nowadays, poly(ethylene glycol) (PEG) is routinely used for these purposes. However, there is increasing evidence that PEG has limited long-term stability, particularly in vivo. Here we investigate poly(2-methyl-2-oxazoline) (PMOXA) as a potential alternative polymer. We designed comb copolymers consisting of a polycationic poly(l-lysine) backbone and PMOXA side chains by analogy to precisely studied and highly protein-repellent PEG-based systems. Using optical waveguide lightmode spectroscopy, we quantitatively compare the in situ self-assembly of the comb copolymers on negatively charged surfaces and the exposure of the formed monolayers to full human serum. We find that the PMOXA-based coatings with an optimal side-chain grafting density eliminate protein adsorption to a level of <2 ng/cm2; that is, they quantitatively equal the protein-repellent properties of the best PEG-based coatings.
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Boschker, H. T. S., Nold, S. C., Wellsbury, P., Bos, D., de Graaf, W., Pel, R., Parkes, R. J., & Cappenberg, T. E. (1998) · Nature · doi:10.1038/33900 · Cited by 556
Cited by
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533
Walkey, C. D., & Chan, W. C. W. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15233e · Cited by 1,758
Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation
Pelegri-O’Day, E. M., Lin, E.-W., & Maynard, H. D. (2014) · Journal of the American Chemical Society · doi:10.1021/ja504390x · Cited by 622
Poly (2-oxazoline) s as polymer therapeutics
Luxenhofer, R., Han, Y., Schulz, A., Tong, J., He, Z., Kabanov, A. V., & Jordan, R. (2012) · Macromolecular Rapid Communications · doi:10.1002/marc.201200354 · Cited by 470
Polyoxazoline: Chemistry, Properties, and Applications in Drug Delivery
Viegas, T. X., Bentley, M. D., Harris, J. M., Fang, Z., Yoon, K., Dizman, B., Weimer, R., Mero, A., Pasut, G., & Veronese, F. M. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200049d · Cited by 432
Metadata
- Authors
- Konradi, R., Pidhatika, B., Mühlebach, A., & Textor, M.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-01-08
- Volume
- 24
- Issue
- 3
- Pages
- 613-616
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2049975923
- Cited by
- 354
- References
- 1
- FWCI
- 9.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Konradi, R., Pidhatika, B., Mühlebach, A., & Textor, M. (2008). Poly-2-methyl-2-oxazoline: A Peptide-like Polymer for Protein-Repellent Surfaces. Langmuir. https://doi.org/10.1021/la702917z
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