Cited by 470Advanced Polymer Synthesis and CharacterizationNanoparticle-Based Drug Deliverybiodegradable polymer synthesis and properties

Poly (2-oxazoline) s as polymer therapeutics

Open access
Luxenhofer, Robert, Han, Yingchao, Schulz, Anita, Tong, Jing, He, Zhijian, Kabanov, Alexander V., Jordan, Rainer·2012·Macromolecular Rapid Communications

Abstract

Poly(2‐oxazoline)s (POx) are currently discussed as an upcoming polymer platform for biomaterials design and especially for polymer therapeutics. POx meet specific requirements needed for the development of next‐generation polymer therapeutics such as biocompatibility, high modulation of solubility, variation of size, architecture as well as chemical functionality. Although in the early 1990s first and promising POx‐based systems were presented, the field lay dormant for almost two decades. Only very recently, POx‐based polymer therapeutics came back into the focus of very intensive research. In this review, we give an overview on the chemistry and physicochemical properties of POx and summarize the research of POx–protein conjugates, POx–drug conjugates, POx‐based polyplexes and POx micelles for drug delivery.

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  1. [3]Schwekendiek K Glorius F Synthesis-Journal of Synthetic Organic Chemistry 2006 2996 3002
  2. [83]Qiu LY Bae YH Pharm Res 2006 23 1 30 16392022
  3. [130]Luxenhofer R Doctoral Thesis TU München 2007 Garching Germany
  4. [148]Harris JM Bentley MD Viegas TX 8th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice 2010

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Authors
Luxenhofer, R., Han, Y., Schulz, A., Tong, J., He, Z., Kabanov, A. V., & Jordan, R.
Affiliations
  • Technische Universität Dresden (DE)
  • Wuhan University of Technology (CN)
  • University of Nebraska Medical Center (US)
  • Center for Regenerative Therapies Dresden (DE)
Corresponding author
  • Luxenhofer, Robert
  • Jordan, Rainer
Venue
Macromolecular Rapid Communications
Publisher
Wiley
Published
2012-08-03
Volume
33
Issue
19
Pages
1613-1631
ISSN
  • 1022-1336 (ISSN-L)
  • 1521-3927
OpenAlex
W2065735911
Cited by
470
References
194
Citations by year
2026: 22 · 2025: 21 · 2024: 28 · 2023: 23 · 2022: 28 · 2021: 42 · 2020: 43 · 2019: 43 · 2018: 47 · 2017: 39 · 2016: 42 · 2015: 37 · 2014: 28 · 2013: 23 · 2012: 3
FWCI
1.39
Type
journal article
Language
en
Open access
Locations
  • Macromolecular Rapid Communications (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • China Scholarship Council
  • Zentrum für Regenerative Therapien Dresden
  • National Cancer Institute (U01 CA116591, U01CA151806, R01CA116591)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords
poly(2-oxazoline), polymer therapeutics, biocompatibility, protein-polymer conjugates, polymer-drug conjugates, polyplexes, micelles, drug delivery, biomaterials
MeSH terms
Biocompatible Materials, Drug Carriers, Pharmaceutical Preparations, Micelles, Oxazoles, Polymers, Proteins, Nanomedicine, Nanoparticles

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