The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Fmoc-Diphenylalanine Self-Assembly Mechanism Induces Apparent p Ka Shifts
Abstract
We report the effect of pH on the self-assembly process of Fmoc-diphenylalanine (Fmoc-FF) into fibrils consisting of antiparallel beta-sheets, and show that it results in two apparent pKa shifts of approximately 6.4 and approximately 2.2 pH units above the theoretical pKa (3.5). Using Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), wide angle X-ray scattering (WAXS), and oscillatory rheology, these two transitions were shown to coincide with significant structural changes. An entangled network of flexible fibrils forming a weak hydrogel dominates at high pH, while nongelling flat rigid ribbons form at intermediate pH values. Overall, this study provides further understanding of the self-assembly mechanism of aromatic short peptide derivatives.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Supramolecular Chemistry: Concepts and Perspectives
Lehn, J. (1995) · Wiley eBooks · doi:10.1002/3527607439 · Cited by 9,864
Whitesides, G. M., & Grzybowski, B. (2002) · Science · doi:10.1126/science.1070821 · Cited by 7,439
Hydrogels for Tissue Engineering
Lee, K. Y., & Mooney, D. J. (2001) · Chemical Reviews · doi:10.1021/cr000108x · Cited by 5,277
Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers
Hartgerink, J. D., Beniash, E., & Stupp, S. I. (2001) · Science · doi:10.1126/science.1063187 · Cited by 3,601
Fabrication of novel biomaterials through molecular self-assembly
Zhang, S. (2003) · Nature Biotechnology · doi:10.1038/nbt874 · Cited by 3,347
Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes
Reches, M., & Gazit, E. (2003) · Science · doi:10.1126/science.1082387 · Cited by 2,530
EMAN: Semiautomated Software for High-Resolution Single-Particle Reconstructions
Ludtke, S. J., Baldwin, P. R., & Chiu, W. (1999) · Journal of Structural Biology · doi:10.1006/jsbi.1999.4174 · Cited by 2,391
What vibrations tell about proteins
Barth, A., & Zscherp, C. (2002) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583502003815 · Cited by 2,088
Jayawarna, V., Ali, M., Jowitt, T. A., Miller, A. F., Saiani, A., Gough, J. E., & Ulijn, R. V. (2006) · Advanced Materials · doi:10.1002/adma.200501522 · Cited by 1,028
Self-citationSmith, A. M., Williams, R. J., Tang, C., Coppo, P., Collins, R. F., Turner, M. L., Saiani, A., & Ulijn, R. V. (2008) · Advanced Materials · doi:10.1002/adma.200701221 · Cited by 995
Self-citation
Cited by
Tao, K., Levin, A., Adler-Abramovich, L., & Gazit, E. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00889a · Cited by 482
Chitosan–dipeptide hydrogels as potential anticancer drug delivery systems
Shim, J., Kang, J., & Yun, S. I. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.07.134 · Cited by 46
Metadata
- Authors
- Tang, C., Smith, A. M., Collins, R. F., Ulijn, R. V., & Saiani, A.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-06-19
- Volume
- 25
- Issue
- 16
- Pages
- 9447-9453
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2049135139
- Cited by
- 444
- References
- 26
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Fmoc-Diphenylalanine Self-Assembly Mechanism Induces Apparent p Ka Shifts. https://app.cochat.ai/papers/10.1021/la900653q
- The paper
- Tang, C., Smith, A. M., Collins, R. F., Ulijn, R. V., & Saiani, A. (2009). Fmoc-Diphenylalanine Self-Assembly Mechanism Induces Apparent p Ka Shifts. Langmuir. https://doi.org/10.1021/la900653q
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
