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Predicting Controlled-Release Behavior of Degradable PLA-b-PEG-b-PLA Hydrogels
Abstract
This paper describes the development and application of scaling laws relating bulk-degradation behavior of poly(lactic acid)−poly(ethylene glycol)−poly(lactic acid) (PLA- b -PEG- b -PLA) copolymer hydrogels to the ever-changing transport properties during network degradation. Specifically, the relationships developed were used to extend previous work and to predict the effects of cross-linking density and hydrolytic degradation rate on the controlled release of high molecular weight proteins from these hydrogels. Theoretical drug release profiles, obtained using scaling laws, agree qualitatively with experimental observations and show a decrease in the protein release rate with an increase in protein size, extent of macromer functionalization, and macromer concentration. Quantitative predictions of release behavior were possible under certain experimental conditions.
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Citations
Cited by
Hydrogels in controlled release formulations: Network design and mathematical modeling
Lin, C.-C., & Metters, A. T. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.004 · Cited by 1,768
Self-citationStimuli-responsive hydrogels in drug delivery and tissue engineering
Sood, N., Bhardwaj, A., Mehta, S., & Mehta, A. (2016) · Drug Delivery · doi:10.3109/10717544.2014.940091 · Cited by 426
Therapeutic applications of hydrogels in oral drug delivery
Sharpe, L. A., Daily, A. M., Horava, S. D., & Peppas, N. A. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.902047 · Cited by 354
Matrices and scaffolds for protein delivery in tissue engineering
Tessmar, J. K., & Göpferich, A. M. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.020 · Cited by 346
Advances in Bioactive Hydrogels to Probe and Direct Cell Fate
DeForest, C. A., & Anseth, K. S. (2012) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-062011-080945 · Cited by 323
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Metadata
- Authors
- Mason, M. N., Metters, A. T., Bowman, C. N., & Anseth, K. S.
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2001-05-19
- Volume
- 34
- Issue
- 13
- Pages
- 4630-4635
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2042227682
- Cited by
- 202
- References
- 0
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mason, M. N., Metters, A. T., Bowman, C. N., & Anseth, K. S. (2001). Predicting Controlled-Release Behavior of Degradable PLA-b-PEG-b-PLA Hydrogels. Macromolecules. https://doi.org/10.1021/ma010025y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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