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Cited by 183

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Synthesis, Characterization, and Stereocomplex-Induced Gelation of Block Copolymers Prepared by Ring-Opening Polymerization of l(d)-Lactide in the Presence of Poly(ethylene glycol)

Li, Suming, Vert, Michel·2003·Macromolecules

Abstract

A series of block copolymers were synthesized by ring-opening polymerization of l ( d )-lactide in the presence of mono- or dihydroxyl poly(ethylene glycol) (PEG) using zinc metal as a catalyst. The resulting diblock and triblock copolymers with relatively short polylactide (PLA) blocks were characterized by various analytical techniques such as 1 H NMR, SEC, DSC, and X-ray diffraction. The data showed that the copolymers were semicrystalline materials with predominant PEG crystallization although PLA blocks crystallized slightly in some cases. Solubilization tests showed that both the composition and molar mass are determining factors in the water solubility of the copolymers. Bioresorbable hydrogels were prepared from aqueous solutions containing both poly( l -lactide)/PEG and poly( d -lactide)/PEG block copolymers. Hydrogel formation resulted from stereocomplexation occurring between poly( l -lactide) and poly( d -lactide) blocks.

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Metadata

Authors
Li, S., & Vert, M.
Venue
Macromolecules
Published
2003-09-27
Volume
36
Issue
21
Pages
8008-8014
ISSN
  • 0024-9297 (ISSN-L)
  • 1520-5835
OpenAlex
W2092377933
Cited by
183
References
1
FWCI
4.44
Type
journal article
Language
en
Open access
closed

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