Cited by 994Hydrogels: synthesis, properties, applicationsCollagen: Extraction and CharacterizationSilk-based biomaterials and applications

Hydrogels in a historical perspective: From simple networks to smart materials

Buwalda, Sytze J., Boere, Kristel W.M., Dijkstra, Pieter J., Feijen, Jan, Vermonden, Tina, Hennink, Wim E.·2014·Journal of Controlled Release

Abstract

Over the past decades, significant progress has been made in the field of hydrogels as functional biomaterials. Biomedical application of hydrogels was initially hindered by the toxicity of crosslinking agents and limitations of hydrogel formation under physiological conditions. Emerging knowledge in polymer chemistry and increased understanding of biological processes resulted in the design of versatile materials and minimally invasive therapies. Hydrogel matrices comprise a wide range of natural and synthetic polymers held together by a variety of physical or chemical crosslinks. With their capacity to embed pharmaceutical agents in their hydrophilic crosslinked network, hydrogels form promising materials for controlled drug release and tissue engineering. Despite all their beneficial properties, there are still several challenges to overcome for clinical translation. In this review, we provide a historical overview of the developments in hydrogel research from simple networks to smart materials.

Integrity signals

Registry

Crossref · 10.1016/j.jconrel.2014.03.052

Cites

331 of 331 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The compactness of hydrogels in aqueous media is maintained by physical cross-linking and chemical cross-linking.

    “The compactness of hydrogels in aqueous media is maintained by physical cross-linking (e.g., entanglements, crystallites) and, also, chemical cross-linking [6,7].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Buwalda, S. J., Boere, K. W. M., Dijkstra, P. J., Feijen, J., Vermonden, T., & Hennink, W. E.
Affiliations
  • Utrecht University (NL)
  • University of Twente (NL)
Corresponding author
Buwalda, Sytze J.
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2014-09
Volume
190
Pages
254-273
ISSN
0168-3659 (ISSN-L)
OpenAlex
W2118087101
Cited by
994
References
331
Citations by year
2026: 56 · 2025: 79 · 2024: 86 · 2023: 124 · 2022: 93 · 2021: 109 · 2020: 93 · 2019: 95 · 2018: 79 · 2017: 62 · 2016: 69 · 2015: 42 · 2014: 6
FWCI
3.97
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Controlled Release (publishedVersion)
  • PubMed (publishedVersion)
  • University of Twente Research Information (publishedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion)
  • University of Twente Research Information (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Keywords
hydrogels, crosslinking agents, physical crosslinks, chemical cross-links, natural polymers, synthetic polymers, controlled drug release, tissue engineering, smart materials, biomedical applications, clinical translation
MeSH terms
Biocompatible Materials, Delayed-Action Preparations, Drug Carriers, Humans, Polyethylene Glycols, Polyhydroxyethyl Methacrylate, Hydrogels, History, 20th Century, History, 21st Century

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review