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Enzymatic Degradability of Poly(lactide): Effects of Chain Stereochemistry and Material Crystallinity
Abstract
Polylactide (PLA) stereocopolymers with ( l ) repeat unit contents of 75%, 80%, 82%, 85%, 90%, 91%, 92%, 94%, and 95% were prepared from mixtures of ( l )-/( d )-lactide and ( l )-/ meso -lactide. Compression molding of these products gave amorphous films which, for ( l ) contents ≥90%, were also annealed above T g to crystallize. Analyses by differential scanning calorimetry and wide angle X-ray scattering gave information on the crystalline order of PLA films. For identical ( l ) contents, stereocopolymers of ( l )-/( d )-lactide had higher crystallinities than those from ( l )-/ meso -lactide. PLA films were incubated with proteinase K (from Tritirachium album ), and the enzyme-catalyzed film weight loss rates were measured. Film crystallinity, chain stereochemical composition, and repeat unit sequence distribution were analyzed as independent variables affecting film enzymatic hydrolysis. Amorphous films from ( l )/( d )-lactide copolymerizations with ( l ) compositions ranging from 80% to 95% exhibited film weight loss rates that were almost identical. Also, amorphous PLA films prepared from ( l )-/ meso -lactide copolymers for ( l ) contents of 80−95% showed a similar invariability in weight loss rates. It was concluded that proteinase K has a high degree of tolerance for ( d ) repeat units. Amorphous PLA films from ( l )-lactide/ meso -lactide copolymerizations had weight loss rates which were about 43% slower than amorphous PLA films from ( l )-/( d )-lactide copolymerizations. These results were analyzed considering differences in chain stereosequence distributions. Proteinase K showed an extraordinarily high sensitivity to film crystalline order. For example, the decrease in the film weight loss rate due to crystalline order for a 95% ( l ) ( l )-/( d )-lactide stereocopolymer was 93%.
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Citations
Cites
Bioresorbability and biocompatibility of aliphatic polyesters
Vert, M., Li, S. M., Spenlehauer, G., & Guerin, P. (1992) · Journal of Materials Science: Materials in Medicine · doi:10.1007/bf00701240 · Cited by 770
Miller, R. A., Brady, J. M., & Cutright, D. E. (1977) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820110507 · Cited by 722
Proteinase K from Tritirachium album Limber
EBELING, W., HENNRICH, N., KLOCKOW, M., METZ, H., ORTH, H. D., & LANG, H. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03671.x · Cited by 639
Kricheldorf, H. R., Berl, M., & Scharnagl, N. (1988) · Macromolecules · doi:10.1021/ma00180a002 · Cited by 597
Li, S., Garreau, H., & Vert, M. (1990) · Journal of Materials Science: Materials in Medicine · doi:10.1007/bf00701077 · Cited by 488
Polylactide stereochemistry: effect on enzymic degradability
Reeve, M. S., McCarthy, S. P., Downey, M. J., & Gross, R. A. (1994) · Macromolecules · doi:10.1021/ma00081a030 · Cited by 433
Self-citationStudies of composition and crystallinity of bacterial poly(β-hydroxybutyrate-co-β-hydroxyvalerate)
Bloembergen, S., Holden, D. A., Hamer, G. K., Bluhm, T. L., & MARCHESSAULT, R. H. (1986) · Macromolecules · doi:10.1021/ma00165a034 · Cited by 384
Enzymic Hydrolysis of Polylactic Acid
Williams, D. F. (1981) · Engineering in Medicine · doi:10.1243/emed_jour_1981_010_004_02 · Cited by 356
Resorbable materials of poly(l-lactide)
Leenslag, J. W., Pennings, A. J., Bos, R. R. M., Rozema, F. R., & Boering, G. (1987) · Biomaterials · doi:10.1016/0142-9612(87)90121-9 · Cited by 329
More about the degradation of LA/GA-derived matrices in aqueous media
Vert, M., Li, S., & Garreau, H. (1991) · Journal of Controlled Release · doi:10.1016/0168-3659(91)90027-b · Cited by 295
Surgical applications of biodegradable polymers in human tissues
Vainionpää, S., Rokkanen, P., & Törmälä, P. (1989) · Progress in Polymer Science · doi:10.1016/0079-6700(89)90013-0 · Cited by 287
Hydrolytic degradation of polyglycolic acid: Tensile strength and crystallinity study
Chu, C. C. (1981) · Journal of Applied Polymer Science · doi:10.1002/app.1981.070260527 · Cited by 265
Configurational structures of lactic acid stereocopolymers as determined by 13C{1H} n.m.r.
Chabot, F., Vert, M., Chapelle, S., & Granger, P. (1983) · Polymer · doi:10.1016/0032-3861(83)90080-0 · Cited by 234
Enzymatic degradation of microbial poly(3‐hydroxybutyrate) films
Kumagai, Y., Kanesawa, Y., & Doi, Y. (1992) · Die Makromolekulare Chemie · doi:10.1002/macp.1992.021930105 · Cited by 232
In vivo degradation of massive poly(α-hydroxy acids): Validation of In vitro findings
Therin, M., Christel, P., Li, S., Garreau, H., & Vert, M. (1992) · Biomaterials · doi:10.1016/0142-9612(92)90027-l · Cited by 230
Controlled release of biologically active compounds from bioerodible polymers
Heller, J. (1980) · Biomaterials · doi:10.1016/0142-9612(80)90060-5 · Cited by 220
Synthesis of copoly(d,l-lactic acid) with relatively low molecular weight and in vitro degradation
Fukuzaki, H., Yoshida, M., Asano, M., & Kumakura, M. (1989) · European Polymer Journal · doi:10.1016/0014-3057(89)90131-6 · Cited by 216
Physical Properties and Biodegradability of Microbial Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)
Shimamura, E., Kasuya, K., Kobayashi, G., Shiotani, T., Shima, Y., & Doi, Y. (1994) · Macromolecules · doi:10.1021/ma00081a041 · Cited by 212
Kricheldorf, H. R., Boettcher, C., & Tönnes, K.-U. (1992) · Polymer · doi:10.1016/0032-3861(92)90459-a · Cited by 208
Stereoregular bioresorbable polyesters for orthopaedic surgery
Vert, M., Chabot, F., Leray, J., & Christel, P. (1981) · Die Makromolekulare Chemie · doi:10.1002/macp.1981.020051981103 · Cited by 206
Preparation and in vitro degradation properties of polylactide microcapsules.
MAKINO, K., ARAKAWA, M., & KONDO, T. (1985) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.33.1195 · Cited by 198
Polylactones: 6. Influence of various metal salts on the optical purity of poly(L-lactide)
Kricheldorf, H., & Serra, A. (1985) · Polymer Bulletin · doi:10.1007/bf00271606 · Cited by 189
Controlled release of biologically active compounds from bioerodible polymers
HELLER, J. (2006) · The Biomaterials · doi:10.1016/b978-008045154-1/50001-0 · Cited by 188
Shirakura, Y., Fukui, T., Saito, T., Okamoto, Y., Narikawa, T., Koide, K., Tomita, K., Takemasa, T., & Masamune, S. (1986) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(86)90118-2 · Cited by 187
Kumagai, Y., & Doi, Y. (1992) · Polymer Degradation and Stability · doi:10.1016/0141-3910(92)90062-a · Cited by 183
Preparation and properties of absorbable fibres from l-lactide copolymers
Penning, J. P., Dijkstra, H., & Pennings, A. J. (1993) · Polymer · doi:10.1016/0032-3861(93)90212-s · Cited by 168
Vert, M., Li, S., & Garreau, H. (1992) · Clinical Materials · doi:10.1016/0267-6605(92)90077-7 · Cited by 150
Gu, J., Eberiel, D. T., McCarthy, S. P., & Gross, R. A. (1993) · Journal of Polymers and the Environment · doi:10.1007/bf01418207 · Cited by 124
Self-citationPolylactic acid as a biodegradable carrier for contraceptive steroids
Jackanicz, T. M., Nash, H. A., Wise, D. L., & Gregory, J. B. (1973) · Contraception · doi:10.1016/0010-7824(73)90033-4 · Cited by 119
Abe, H., Matsubara, I., Doi, Y., Hori, Y., & Yamaguchi, A. (1994) · Macromolecules · doi:10.1021/ma00099a013 · Cited by 117
Bio-absorbable plates and screws for internal fixation of mandibular fractures
Bos, R. R. M., Rozema, F. R., Boering, G., et al. (1989) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/s0901-5027(89)80035-9 · Cited by 114
Li, S., & Vert, M. (1994) · Macromolecules · doi:10.1021/ma00089a031 · Cited by 112
Nishida, H., & Tokiwa, Y. (1993) · Journal of Polymers and the Environment · doi:10.1007/bf01457654 · Cited by 111
Kemnitzer, J. E., McCarthy, S. P., & Gross, R. A. (1992) · Macromolecules · doi:10.1021/ma00048a011 · Cited by 102
Self-citationEnzymatic degradation of poly(hydroxyalkanoates) by Pseudomonas pickettii
Yamada, K., Mukai, K., & Doi, Y. (1993) · International Journal of Biological Macromolecules · doi:10.1016/0141-8130(93)90040-s · Cited by 98
Biodegradable Polymers for Orthopedic Applications
Zhang, X., Mattheus, Goosen, M. F. A., Wyss, S. P., & Pichora, D. R. (1993) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/15321799308021434 · Cited by 89
Bone-plates and screws of bioabsorbable poly (L-lactide) An animal pilot study
Bos, R. R. M., Rozema, F. R., Boering, G., Nijenhuis, A. J., Pennings, A. J., & Jansen, H. W. B. (1989) · British Journal of Oral and Maxillofacial Surgery · doi:10.1016/s0266-4356(89)80004-x · Cited by 75
1H‐ and 13C‐{1H}‐NMR spectra of stereocopolymers of lactide
Lillie, E. D., & Schulz, R. C. (1975) · Die Makromolekulare Chemie · doi:10.1002/macp.1975.021760629 · Cited by 73
Physical properties and biodegradability of blends of isotactic and atactic poly(3‐hydroxybutyrate)
Kumagai, Y., & Doi, Y. (1992) · Die Makromolekulare Chemie Rapid Communications · doi:10.1002/marc.1992.030130308 · Cited by 60
Enzymatic degradation of poly([R,S] ?-hydroxybutyrate)
Jesudason, J. J., MARCHESSAULT, R. H., & Saito, T. (1993) · Journal of Polymers and the Environment · doi:10.1007/bf01418201 · Cited by 39
Poly (lactic acid). I. Stereosequence distribution in the polymerization of racemic dilactide
Schindler, A., & Harper, D. (1976) · Journal of Polymer Science Polymer Letters Edition · doi:10.1002/pol.1976.130141205 · Cited by 38
Cited by
An Overview of Polylactides as Packaging Materials
Auras, R., Harte, B., & Selke, S. (2004) · Macromolecular Bioscience · doi:10.1002/mabi.200400043 · Cited by 3,454
Tokiwa, Y., Calabia, B. P., Ugwu, C. U., & Aiba, S. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10093722 · Cited by 1,782
Biodegradability and biodegradation of poly(lactide)
Tokiwa, Y., & Calabia, B. P. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0488-1 · Cited by 665
Payne, J., & Jones, M. D. (2021) · ChemSusChem · doi:10.1002/cssc.202100400 · Cited by 426
A circular economy approach to plastic waste
Payne, J., McKeown, P., & Jones, M. D. (2019) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2019.05.014 · Cited by 385
Metadata
- Authors
- MacDonald, R. T., McCarthy, S. P., & Gross, R. A.
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 1996-01-01
- Volume
- 29
- Issue
- 23
- Pages
- 7356-7361
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2007589252
- Cited by
- 260
- References
- 41
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- closed
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