The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Ring-Opening Polymerization of 1,4,8-Trioxaspiro[4.6]-9-undecanone: A New Route to Aliphatic Polyesters Bearing Functional Pendent Groups
Abstract
A straightforward and very efficient pathway has been reported for the synthesis of a functional derivative of ε-caprolactone, i.e. 5-ethylene ketal ε-caprolactone. This new monomer has been homopolymerized and copolymerized with ε-caprolactone in a well-controlled manner, strongly suggesting absence of any side reactions. Deacetalization of the polyester chains is complete and reduction of the ketone groups into hydroxyl groups as well. No chain scission is observed to occur in the course of these two derivatization reactions. Thus, aliphatic polyesters bearing either ketone pendent groups or hydroxyl pendent groups can be easily prepared, which raises new application prospects. These materials proved to be easily redispersed in an aqueous medium. They form stable colloidal nanodispersions (e.g. 100 nm). These suspensions are stable more than 48 h at room temperature and may be viewed as potential drug colloidal vectors with a core−shell like structure. Different types of reactive groups on the surface of these nanoparticulate vectors are indeed available to the binding of species selected for molecular recognition and drug targeting. For instance, the well-known reactivity of ketones toward primary amines is a direct route to attach peptides onto biodegradable and biocompatible aliphatic polyesters. Poly(ε-caprolactone) with hydroxyl groups reactive toward triethylaluminum provides a macroinitiator for lactone and lactide polymerization, so that biodegradable and biocompatible functional comb, graft, and dendritic aliphatic polyesters can now be synthesized.
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In the citing paper
“The ketal groups are used as protected ketones, whose reduction by sodium borohydride led to pendent hydroxyl groups, together with an increase of the hydrophilic character of the hydroxy-polyester.”
From Recent advances in the synthesis of aliphatic polyesters by ring-opening polymerization☆ (2008) · cites this paper as [101]
In the citing paper
“This γ-ketal lactone is homo-polymerized [101] and copolymerized [102] with ε-caprolactone.”
From Recent advances in the synthesis of aliphatic polyesters by ring-opening polymerization☆ (2008) · cites this paper as [101]
Citations
Cites
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Flagged first, then by citations
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Cited by
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Applications of Orthogonal “Click” Chemistries in the Synthesis of Functional Soft Materials
Iha, R. K., Wooley, K. L., Nyström, A. M., Burke, D. J., Kade, M. J., & Hawker, C. J. (2009) · Chemical Reviews · doi:10.1021/cr900138t · Cited by 1,474
Biodegradable synthetic polymers: Preparation, functionalization and biomedical application
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Chemical syntheses of biodegradable polymers
Okada, M. (2002) · Progress in Polymer Science · doi:10.1016/s0079-6700(01)00039-9 · Cited by 1,239
Recent advances in the synthesis of aliphatic polyesters by ring-opening polymerization☆
JEROME, C., & LECOMTE, P. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.02.008 · Cited by 590
Aliphatic Polyesters: Synthesis, Properties and Applications
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Metadata
- Authors
- Tian, D., Dubois, P., Grandfils, C., & Jérôme, R.
- Affiliations
- University of Liège (BE)
- Center for Education and Research on Macromolecules (CERM), University of Liège, Sart-Tilman, B6, 4000 Liège, Belgium
- ORCID
- Grandfils, Christian
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 1997-02-01
- Volume
- 30
- Issue
- 3
- Pages
- 406-409
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2030275481
- Cited by
- 140
- References
- 15
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 11
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecules (publishedVersion)
- ORBi (University of Liège) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- ring-opening polymerization, aliphatic polyesters, deacetalization, ketone reduction, aqueous dispersion stability, drug delivery vectors, peptide conjugation, biodegradable polyesters
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