Reaction Behavior of Biodegradable, Photo-Cross-Linkable Polyanhydrides
Abstract
The polymerization behavior of a new class of dimethacrylated anhydride monomers that react to form highly cross-linked degradable networks was investigated using various photoinitiation schemes. Polymerizations occurred in seconds to minutes depending on the initiating conditions, and conversions in excess of 0.95 were achievable. A photobleaching visible light initiating system was used to improve the depth of cure for the production of polymers with appreciable dimensions. One potential application for the proposed multifunctional monomers is in vivo curing of high-strength, degradable polymers for fracture fixation or filling of trabecular bone defects.
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In vivo studies have demonstrated that the tyrosine-derived polycarbonate was biocompatible and promoted significant bone growth.
“Invivo studies have demonstrated that the polymer was biocompatible and promoted significant bone growth”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Muggli et al., 1998
Photo cross-linkable polyanhydrides have been developed for use in orthopaedic applications, particularly focusing on achieving high mechanical strength.
“Photo cross-linkable polyanhydrides have also been developed for use in orthopaedic applications, particularly focusing on achieving high mechanical strength.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Muggli et al., 1998
Tyrosine-based polycarbonates have been reported as promising degradable polymers for use in orthopaedic applications.
“Tyrosine-based polycarbonates (Figure 5) have been reported as promising degradable polymers for use in orthopaedic applications”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Muggli et al., 1998
Studies have shown that the carbonate group hydrolyzes at a faster rate than the ester group, and the amide bond is not labile in vitro.
“Studies have shown (Muggli et al., 1998) that the carbonate group hydrolyzes at a faster rate than the ester group, and the amide bond is not labile in vitro.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Muggli et al., 1998
Cites
Odian, G. (2004) · doi:10.1002/047147875x · Cited by 7,158 · see citing works
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Biodegradable synthetic polymers for tissue engineering
CSIRO Molecular Science, B. 1., & Gunatillake, P. (2003) · European Cells and Materials · doi:10.22203/ecm.v005a01 · Cited by 1,765 · see citing works
“The systems developed are based on dimethacrylated anhydrides (Muggli et al., 1998; Burkoth and Anseth, 2000).”
BackgroundInfluentialInjectable biodegradable materials for orthopedic tissue engineering
Temenoff, J. S., & Mikos, A. G. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00108-3 · Cited by 554 · see citing works
- Authors
- Muggli, D. S., Burkoth, A. K., Keyser, S. A., Lee, H. R., & Anseth, K. S.
- Affiliations
- University of Colorado Boulder (US)
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 1998-05-28
- Volume
- 31
- Issue
- 13
- Pages
- 4120-4125
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2035867061
- Cited by
- 107
- References
- 1
- Citations by year
- 2025: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2016: 5 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecules (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Photopolymerization techniques and applications
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- biodegradable polymers, photocrosslinking, photopolymerization, photoinitiation, photobleaching, depth of cure, fracture fixation, crosslinked polymer networks
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