Injectable biodegradable materials for orthopedic tissue engineering

Temenoff, Johnna S; Mikos, Antonios G

doi:10.1016/s0142-9612(00)00108-3

Cited by 555Bone Tissue Engineering MaterialsHydrogels: synthesis, properties, applicationsbiodegradable polymer synthesis and properties

Injectable biodegradable materials for orthopedic tissue engineering

Temenoff, Johnna S, Mikos, Antonios G·2000·Biomaterials

DOI 10.1016/s0142-9612(00)00108-3

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Abstract

The large number of orthopedic procedures performed each year, including many performed arthroscopically, have led to great interest in injectable biodegradable materials for regeneration of bone and cartilage. A variety of materials have been developed for these applications, including ceramics, naturally derived substances and synthetic polymers. These materials demonstrate overall biocompatibility and appropriate mechanical properties, as well as promote tissue formation, thus providing an important step towards minimally invasive orthopedic procedures. This review provides a comparison of these materials based on mechanical properties, biocompatibility and regeneration efficacy. Advantages and disadvantages of each material are explained and design criteria for injectable biodegradable systems are provided.

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PPF copolymers degrade to propylene glycol, poly(acrylic acid-co-fumaric acid) and fumaric acid.
“The copolymers degrade to propylene glycol, poly(acrylic acidco-fumaric acid) and fumaric acid”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Temenoff and Mikos, 2000
A number of studies have reported on the synthesis, properties and in vivo degradation characteristics of PPF.
“A number of studies have reported on the synthesis, properties (Kharas et al., 1997;Peter et al., 1998a;Temenoff and Mikos, 2000) and in-vivo degradation (Yaszemski et al., 1994;Frazier et al., 1997;Peter et al., 1998a) characteristics of poly(propylene fumarate).”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Temenoff and Mikos, 2000
A number of methods have been reported to prepare PPF, and each results in different polymer properties.
“A number of methods have been reported to prepare PPF, and each results in different polymer properties”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Temenoff and Mikos 2000
PPF-based degradable polymer compositions, including injectable biodegradable materials, have been reported in the literature.
“PPF based degradable polymer compositions including injectable biodegradable materials have been reported in the literature”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Temenoff and Mikos, 2000
ß-TCP was particularly useful for reinforcement of PPF, and compositions without TCP reinforcement disintegrated very early in the implant.
“ß-TCP was particularly useful for reinforcement, and compositions without TCP reinforcement disintegrated very early in the implant”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Temenoff and Mikos, 2000

Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage.
Wakitani, S., Goto, T., Pineda, S. J., Young, R. G., Mansour, J. M., Caplan, A. I., & Goldberg, V. M. (1994) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199404000-00013 · Cited by 1,604 · see citing works
Articular cartilage: tissue design and chondrocyte-matrix interactions.
Buckwalter, J. A., & Mankin, H. J. (1998) · PubMed · Cited by 918 · see citing works
Interspecies comparisons of in situ intrinsic mechanical properties of distal femoral cartilage
Athanasiou, K. A., Rosenwasser, M. P., Buckwalter, J. A., Malinin, T. I., & Mow, V. C. (1991) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100090304 · Cited by 751 · see citing works
Evolution of bone transplantation: molecular, cellular and tissue strategies to engineer human bone
Yaszemski, M. J., Payne, R. G., Hayes, W. C., Langer, R., & Mikos, A. G. (1996) · Biomaterials · doi:10.1016/0142-9612(96)85762-0 · Cited by 729 · see citing works
Self-citation
Skeletal Repair by in Situ Formation of the Mineral Phase of Bone
Constantz, B. R., Ison, I. C., Fulmer, M. T., Poser, R. D., Smith, S. T., VanWagoner, M., Ross, J., Goldstein, S. A., Jupiter, J. B., & Rosenthal, D. I. (1995) · Science · doi:10.1126/science.7892603 · Cited by 725 · see citing works
Handbook of Biodegradable Polymers
(1998) · CRC Press eBooks · doi:10.1201/9780367802219 · Cited by 712 · see citing works
Biodegradation behavior of various calcium phosphate materials in bone tissue
Klein, C. P. A. T., Driessen, A. A., de Groot, K., & van den Hooff, A. (1983) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820170505 · Cited by 585 · see citing works
Transdermal photopolymerization for minimally invasive implantation
Elisseeff, J. H., Anseth, K. S., Sims, D. C., McIntosh, W., Randolph, M. A., & Langer, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3104 · Cited by 576 · see citing works
Handbook of Biodegradable Polymers
(1998) · CRC Press eBooks · doi:10.1201/9781420049367 · Cited by 498 · see citing works
Transformation of biphasic calcium phosphate ceramics in vivo : Ultrastructural and physicochemical characterization
Daculsi, G., LeGeros, R. Z., Nery, E. B., Lynch, K. L., & Kerebel, B. (1989) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820230806 · Cited by 496 · see citing works
Articular Cartilage: Injuries and Potential for Healing
Buckwalter, J. A. (1998) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.1998.28.4.192 · Cited by 481 · see citing works
Hyaluronic acid‐based polymers as cell carriers for tissue‐engineered repair of bone and cartilage
Solchaga, L. A., Dennis, J. E., Goldberg, V. M., & Caplan, A. I. (1999) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100170209 · Cited by 396 · see citing works
Biodegradable polymer scaffolds to regenerate organs
Thomson, R. C., Wake, M. C., Yaszemski, M. J., & Mikos, A. G. (1995) · Advances in polymer science · doi:10.1007/3540587888_18 · Cited by 386 · see citing works
Self-citation
Polymer concepts in tissue engineering
Peter, S. J., Miller, M. J., Yasko, A. W., Yaszemski, M. J., & Mikos, A. G. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199824)43:4 · Cited by 380 · see citing works
Biomechanical and Histological Evaluation of a Calcium Phosphate Cement*
FRAKENBURG, E. P., Goldstein, S. A., Bauer, T. W., HARRIS, S. A., & Poser, R. D. (1998) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199808000-00004 · Cited by 361 · see citing works
Composition and Dynamics of Articular Cartilage: Structure, Function, and Maintaining Healthy State
Cohen, N. P., Foster, R. J., & Mow, V. C. (1998) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.1998.28.4.203 · Cited by 352 · see citing works
Comparative study of the intrinsic mechanical properties of the human acetabular and femoral head cartilage
Athanasiou, K. A., Agarwal, A., & Dzida, F. J. (1994) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100120306 · Cited by 343 · see citing works
Chondrocyte‐fibrin matrix transplants for resurfacing extensive articular cartilage defects
Hendrickson, D. A., Nixon, A. J., Grande, D. A., Todhunter, R. J., Minor, R. M., Erb, H. N., & Lust, G. (1994) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100120405 · Cited by 290 · see citing works
De Novo Cartilage Generation Using Calcium Alginate-Chondrocyte Constructs
Paige, K. T., Griffith, L. G., Yaremchuk, M. J., Schloo, B. L., Vacanti, J. P., & Vacanti, C. A. (1996) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199601000-00027 · Cited by 229 · see citing works
Biomechanical topography of human ankle cartilage
Athanasiou, K. A., Niederauer, G. G., & Schenck, R. C. (1995) · Annals of Biomedical Engineering · doi:10.1007/bf02584467 · Cited by 215 · see citing works
Photopolymerizable degradable polyanhydrides with osteocompatibility
Anseth, K. S., Shastri, V. P., & Langer, R. (1999) · Nature Biotechnology · doi:10.1038/6152 · Cited by 205 · see citing works
Crosslinking characteristics of an injectable poly(propylene fumarate)/?-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement
Peter, S. J., Kim, P., Yasko, A. W., Yaszemski, M. J., & Mikos, A. G. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19990305)44:3 · Cited by 205 · see citing works
Self-citation
Non-decay type fast-setting calcium phosphate cement: composite with sodium alginate
Ishikawa, K., Miyamoto, Y., Kon, M., Nagayama, M., & Asaoka, K. (1995) · Biomaterials · doi:10.1016/0142-9612(95)91125-i · Cited by 200 · see citing works
Synthesis of biodegradable poly(propylene fumarate) networks with poly(propylene fumarate)–diacrylate macromers as crosslinking agents and characterization of their degradation products
He, S., Timmer, M. D., Yaszemski, M. J., Yasko, A. W., Engel, P. S., & Mikos, A. G. (2001) · Polymer · doi:10.1016/s0032-3861(00)00479-1 · Cited by 199 · see citing works
Self-citation
In vivo setting behaviour of fast-setting calcium phosphate cement
Miyamoto, Y., Ishikawa, K., Fukao, H., Sawada, M., Nagayama, M., Kon, M., & Asaoka, K. (1995) · Biomaterials · doi:10.1016/0142-9612(95)94147-d · Cited by 186 · see citing works
Estimation of ideal mechanical strength and critical porosity of calcium phosphate cement
Ishikawa, K., & Asaoka, K. (1995) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820291210 · Cited by 183 · see citing works
Tissue Engineered Neocartilage Using Plasma Derived Polymer Substrates and Chondrocytes
Sims, D. C., Butler, P. E. M., Cao, Y. L., Casanova, R., Randolph, M. A., Black, A. C., Vacanti, C. A., & Yaremchuk, M. J. (1998) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199805000-00022 · Cited by 183 · see citing works
In vitro degradation of a poly(propylene fumarate)-based composite material
Yaszemski, M. J., Payne, R. G., Hayes, W. C., Langer, R., & Mikos, A. G. (1996) · Biomaterials · doi:10.1016/0142-9612(96)00008-7 · Cited by 172 · see citing works
Self-citation
Marrow stromal osteoblast function on a poly(propylene fumarate)/β-tricalcium phosphate biodegradable orthopaedic composite
Peter, S. J., Lu, L., Kim, D. J., & Mikos, A. G. (2000) · Biomaterials · doi:10.1016/s0142-9612(99)00254-9 · Cited by 169 · see citing works
Self-citation
Norian SRS Cement Augmentation in Hip Fracture Treatment
Goodman, S. B., Bauer, T. W., Carter, D. R. P., Casteleyn, P., Goldstein, S. A., Kyle, R. F., Larsson, S., Stankewich, C. J., Swiontkowski, M. F., Tencer, A. F., et al. (1998) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199803000-00009 · Cited by 165 · see citing works
Injectable Cartilage
Paige, K. T., Griffith, L. G., Yaremchuk, M. J., Vacanti, J. P., & Vacanti, C. A. (1995) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199511000-00024 · Cited by 164 · see citing works
Effective formulations for the preparation of calcium phosphate bone cements
Driessens, F. C. M., Boltong, M. G., Berm�dez, O., Planell, J. A., Ginebra, M., & Fern�ndez, E. (1994) · Journal of Materials Science Materials in Medicine · doi:10.1007/bf00053338 · Cited by 161 · see citing works
Quantification of the fiber architecture and biaxial mechanical behavior of porcine intestinal submucosa
Sacks, M. S., & Gloeckner, D. C. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199907)46:1 · Cited by 161 · see citing works
Self-citation
Effects of hydroxypropyl methylcellulose and other gelling agents on the handling properties of calcium phosphate cement
Cherng, A., Takagi, S., & Chow, L. C. (1997) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19970605)35:3 · Cited by 156 · see citing works
The Ingrowth of New Bone Tissue and Initial Mechanical Properties of a Degrading Polymeric Composite Scaffold
Yaszemski, M. J., Payne, R. G., Hayes, W. C., Langer, R., Aufdemorte, T. B., & Mikos, A. G. (1995) · Tissue Engineering · doi:10.1089/ten.1995.1.41 · Cited by 149 · see citing works
Self-citation
Histological and compositional evaluations of three types of calcium phosphate cements when implanted in subcutaneous tissue immediately after mixing
Miyamoto, Y., Ishikawa, K., Takechi, M., Toh, T., Yuasa, T., Nagayama, M., & Suzuki, K. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(1999)48:1 · Cited by 148 · see citing works
Kinetic study of bone ingrowth and ceramic resorption associated with the implantation of different injectable calcium-phosphate bone substitutes
Gauthier, O., Bouler, J., Weiss, P., Bosco, J., Daculsi, G., & Aguado, E. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199910)47:1 · Cited by 148 · see citing works
Injectable Cartilage Using Polyethylene Oxide Polymer Substrates
Sims, D. C., Butler, P. E. M., Casanova, R., Lee, B. T., Randolph, M. A., Lee, W. P. A., Vacanti, C. A., & Yaremchuk, M. J. (1996) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199610000-00015 · Cited by 141 · see citing works
Injectable Calcium Phosphate in the Treatment of Distal Radial Fractures
Kopylov, P., Jonsson, K., Thorngren, K. ‐., & Aspenberg, P. (1996) · Journal of Hand Surgery (European Volume) · doi:10.1016/s0266-7681(96)80184-7 · Cited by 136 · see citing works
Short-term implantation effects of a DCPD-based calcium phosphate cement
Frayssinet, P., Gineste, L., Conte, P., Fages, J., & Rouquet, N. (1998) · Biomaterials · doi:10.1016/s0142-9612(97)00163-4 · Cited by 135 · see citing works
Basic properties of calcium phosphate cement containing atelocollagen in its liquid or powder phases
Miyamoto, Y., Ishikawa, K., Takechi, M., Toh, T., Yuasa, T., Nagayama, M., & Suzuki, K. (1998) · Biomaterials · doi:10.1016/s0142-9612(97)00186-5 · Cited by 133 · see citing works
Injectable cartilage. Discussion
Paige, K. T., Griffith, L. G., Yaremchuk, M. J., Vacanti, J. P., Vacanti, C. A., & Johnson, P. C. (1995) · Plastic & Reconstructive Surgery · Cited by 129 · see citing works
TRANSPLANTATION OF ALGINATE MICROCAPSULES
Kulseng, B. E., Skjåk‐Bræk, G., Ryan, L., Andersson, A., King, A., Faxvaag, A., & Espevik, T. (1999) · Transplantation · doi:10.1097/00007890-199904150-00008 · Cited by 125 · see citing works
Non-decay type fast-setting calcium phosphate cement: Hydroxyapatite putty containing an increased amount of sodium alginate
Ishikawa, K., Miyamoto, Y., Takechi, M., Toh, T., Kon, M., Nagayama, M., & Asaoka, K. (1997) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19970905)36:3 · Cited by 116 · see citing works
Antibacterial activity of cured dental resin incorporating the antibacterial monomer MDPB and an adhesion-promoting monomer
Imazato, S., Imai, T., Russell, R. R. B., Torii, M., & Ebisu, S. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19980315)39:4 · Cited by 116 · see citing works
Reaction Behavior of Biodegradable, Photo-Cross-Linkable Polyanhydrides
Muggli, D. S., Burkoth, A. K., Keyser, S. A., Lee, H. R., & Anseth, K. S. (1998) · Macromolecules · doi:10.1021/ma980108n · Cited by 107 · see citing works
In Vitro Degradation of a Poly(Propylene Fumarate)/ β -Tricalcium Phosphate Composite Orthopaedic Scaffold
Peter, S. J., Nolley, J. A., Widmer, M. S., Merwin, J. E., Yaszemski, M. J., Yasko, A. W., Engel, P. S., & Mikos, A. G. (1997) · Tissue Engineering · doi:10.1089/ten.1997.3.207 · Cited by 100 · see citing works
Self-citation
A New Injectable Calcium Phosphate Biomaterial for Immediate Bone Filling of Extraction Sockets: A Preliminary Study in Dogs
Gauthier, O., Boix, D., Grimandi, G., Aguado, E., Bouler, J., Weiss, P., & Daculsi, G. (1999) · Journal of Periodontology · doi:10.1902/jop.1999.70.4.375 · Cited by 95 · see citing works
Development of Poly(Propylene Fumarate-co-Ethylene Glycol) as an Injectable Carrier for Endothelial Cells
Suggs, L. J., & Mikos, A. G. (1999) · Cell Transplantation · doi:10.1177/096368979900800402 · Cited by 94 · see citing works
Self-citation
Bone repair of defects filled with a phosphocalcic hydraulic cement: an in vivo study
Munting, E., Mirtchi, A. A., & Lemaître, J. (1993) · Journal of Materials Science Materials in Medicine · doi:10.1007/bf00122290 · Cited by 93 · see citing works
Synthesis of poly(ethylene glycol)-tethered poly(propylene fumarate) and its modification with GRGD peptide
Jo, S., Engel, P. S., & Mikos, A. G. (2000) · Polymer · doi:10.1016/s0032-3861(00)00117-8 · Cited by 89 · see citing works
Self-citation
Mechanisms of cell activation by heavy metal ions
Wagner, M., Klein, C. L., van Kooten, T. G., & Kirkpatrick, C. J. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19981205)42:3 · Cited by 86 · see citing works
Preparation and characterization of poly(propylene fumarate-co-ethylene glycol) hydrogels
Suggs, L. J., Kao, E. Y., Palombo, L. L., Krishnan, R. S., Widmer, M. S., & Mikos, A. G. (1998) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856298x00073 · Cited by 84 · see citing works
Self-citation
Initial histological evaluation of anti-washout type fast-setting calcium phosphate cement following subcutaneous implantation
Takechi, M., Miyamoto, Y., Ishikawa, K., Toh, T., Yuasa, T., Nagayama, M., & Suzuki, K. (1998) · Biomaterials · doi:10.1016/s0142-9612(98)00114-8 · Cited by 84 · see citing works
Articular cartilage.
Buckwalter, J. A. (1983) · PubMed · Cited by 72 · see citing works
Analysis of a vinyl pyrrolidone/poly(propylene fumarate) resorbable bone cement
Gresser, J. D., Hsu, S., Nagaoka, H. X., Lyons, C. M., Nieratko, D. P., Wise, D. L., Barabino, G. A., & Trantolo, D. J. (1995) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820291011 · Cited by 70 · see citing works
Synthesis and Characterization of a Block Copolymer Consisting of Poly(propylene fumarate) and Poly(ethylene glycol)
Suggs, L. J., Payne, R. G., Yaszemski, M. J., Alemany, L. B., & Mikos, A. G. (1997) · Macromolecules · doi:10.1021/ma970312v · Cited by 59 · see citing works
Self-citation
Dissolution of particulate hydroxyapatite in a macrophage organelle model
Bloebaum, R. D., Lundeen, G. A., Bachus, K. N., Ison, I. C., & Hofmann, A. A. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199804)40:1 · Cited by 35 · see citing works
In vitro cellular responses to bioerodible particles loaded with recombinant human bone morphogenetic protein-2
Puleo, D. A., Huh, W. W., Duggirala, S. S., & DeLuca, P. P. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199807)41:1 · Cited by 32 · see citing works
Self-citation
Transplantation of alginate microcapsules
Kulseng, B. E., Skrak-Braek, G., Ryan, L., Andersson, A., King, A. P., Faxvaag, A., & Espevik, T. (1999) · Transplantation · Cited by 30 · see citing works
In-Vivo Degradation of a Poly(Propylene-Fumarate) Biodegradable, Particulate Composite Bone Cement
Frazier, D. D., Lathi, V. K., Gerhart, T. N., Altobelli, D. E., & Hayes, W. C. (1995) · MRS Proceedings · doi:10.1557/proc-394-15 · Cited by 17 · see citing works
Osteoclastic resorption of bone-like apatite formed on a plastic disk as anin vitro assay system
Matsuoka, H., Nakamura, T., Takadama, H., Yamada, S., Tamura, J., Okada, Y., Oka, M., & Kokubo, T. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199811)42:2 · Cited by 12 · see citing works
Self-citation
Osteocompatibility of Photopolymerizable Anhydride Networks
Shastri, V. P., Marini, R. P., Padera, R. F., Kirchain, S., Tarcha, P. J., & Langer, R. (1998) · MRS Proceedings · doi:10.1557/proc-530-93 · Cited by 11 · see citing works
Untitled work
(1996) · doi:10.1002/(sici)1097-4636(199602)30:2
Untitled work
Jenney (2000) · doi:10.1002/(sici)1097-4636(20000605)50:3
Self-citation
Untitled work
Lu (1999) · doi:10.1002/(sici)1097-4636(199908)46:2
Untitled work
Rhodes (1997) · doi:10.1002/(sici)1097-4636(19971215)37:4
Untitled work
(1997) · doi:10.1002/(sici)1097-4628(19971107)66:6

Flagged first, then by citations

3 of the 71 references couldn’t be matched to a known paper.

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Hydrogels for Tissue Engineering
Lee, K. Y., & Mooney, D. J. (2001) · Chemical Reviews · doi:10.1021/cr000108x · Cited by 5,295 · see citing works
Biodegradable polymers as biomaterials
Nair, L. S., & Laurencin, C. T. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.017 · Cited by 4,416 · see citing works
Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
Peppas, N. A., Hilt, J. Z., Khademhosseini, A., & Langer, R. (2006) · Advanced Materials · doi:10.1002/adma.200501612 · Cited by 4,109 · see citing works
Biodegradable synthetic polymers for tissue engineering
CSIRO Molecular Science, B. 1., & Gunatillake, P. (2003) · European Cells and Materials · doi:10.22203/ecm.v005a01 · Cited by 1,765 · see citing works
“A number of methods have been reported to prepare PPF, and each results in different polymer properties (Peter et al., 1997a,b, 1999; Temenoff and Mikos 2000).”
BackgroundMethodInfluential
Bioactive modification of poly (ethylene glycol) hydrogels for tissue engineering
Zhu, J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.044 · Cited by 1,457 · see citing works
Alginate-Based Biomaterials for Regenerative Medicine Applications
Sun, J., & Tan, H. (2013) · Materials · doi:10.3390/ma6041285 · Cited by 1,368 · see citing works
Poly(lactic acid) fiber: An overview
Gupta, B., Revagade, N., & Hilborn, J. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.01.005 · Cited by 1,360 · see citing works
Stimulus-responsive hydrogels: theory, modern advances, and applications
Koetting, M. C., Peters, J. T., Steichen, S. D., & Peppas, N. A. (2015) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2015.04.001 · Cited by 1,191 · see citing works
Injectable in situ forming biodegradable chitosan–hyaluronic acid based hydrogels for cartilage tissue engineering
Tan, H., Chu, C. R., Payne, K. A., & Marra, K. G. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.080 · Cited by 1,023 · see citing works
Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering
Burdick, J. A., & Anseth, K. S. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00176-x · Cited by 1,008 · see citing works
State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective
Hutmacher, D. W., Schantz, J. T., Lam, C. X. F., Tan, K. C., & Lim, T. C. (2007) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.24 · Cited by 1,007 · see citing works
Shear-thinning hydrogels for biomedical applications
Güvendiren, M., Lu, H. D., & Burdick, J. A. (2011) · Soft Matter · doi:10.1039/c1sm06513k · Cited by 912 · see citing works
Polymeric biomaterials for tissue and organ regeneration
Seal, B. L. (2001) · Materials Science and Engineering R Reports · doi:10.1016/s0927-796x(01)00035-3 · Cited by 893 · see citing works
Piezoelectric Biomaterials for Sensors and Actuators
Chorsi, M. T., Curry, E. J., Chorsi, H. T., Das, R., Baroody, J., Purohit, P. K., Ilieş, H., & Nguyen, T. D. (2018) · Advanced Materials · doi:10.1002/adma.201802084 · Cited by 879 · see citing works
Biodegradable Polymers-A Review on Recent Trends and Emerging Perspectives
Luckachan, G. E., & Pillai, C. K. S. (2011) · Journal of Polymers and the Environment · doi:10.1007/s10924-011-0317-1 · Cited by 767 · see citing works
Biodegradable injectable in situ forming drug delivery systems
Hatefi, A., & Amsden, B. G. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00008-1 · Cited by 728 · see citing works
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Li, Y., Huang, G., Zhang, X., Li, B., Chen, Y., Lu, T., Lu, T. J., & Xu, F. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201201708 · Cited by 727 · see citing works
Self-Folding Thermo-Magnetically Responsive Soft Microgrippers
Breger, J. C., Yoon, C., Xiao, R., Kwag, H. R., Wang, M. O., Fisher, J. P., Nguyen, T. D., & Gracias, D. H. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/am508621s · Cited by 659 · see citing works
A review on biodegradable polymeric materials for bone tissue engineering applications
Sabir, M. I., Xu, X., & Li, L. (2009) · Journal of Materials Science · doi:10.1007/s10853-009-3770-7 · Cited by 641 · see citing works
Injectable, Biodegradable Hydrogels for Tissue Engineering Applications
Tan, H., & Marra, K. G. (2010) · Materials · doi:10.3390/ma3031746 · Cited by 643 · see citing works
In situ crosslinkable hyaluronan hydrogels for tissue engineering
Shu, X. Z., Liu, Y., Palumbo, F. S., Luo, Y., & Prestwich, G. D. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.08.014 · Cited by 640 · see citing works
Plasma electrolytic oxidation of magnesium and its alloys: Mechanism, properties and applications
Darband, G. B., Aliofkhazraei, M., Hamghalam, P., & Valizade, N. (2017) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2017.02.004 · Cited by 596 · see citing works
Biopolymer-Based Hydrogels for Cartilage Tissue Engineering
Balakrishnan, B., & Banerjee, R. (2011) · Chemical Reviews · doi:10.1021/cr100123h · Cited by 549 · see citing works
Recent Advances in Design of Functional Biocompatible Hydrogels for Bone Tissue Engineering
Xu, X. J., Hu, Y., Deng, Y., & Su, J. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202009432 · Cited by 538 · see citing works
Biodegradable Polyurethanes: Synthesis and Applications in Regenerative Medicine
Guelcher, S. A. (2008) · Tissue Engineering Part B Reviews · doi:10.1089/teb.2007.0133 · Cited by 470 · see citing works
Bioinert, biodegradable and injectable polymeric matrix composites for hard tissue replacement: state of the art and recent developments
Mano, J. F., Sousa, R. A., Boesel, L. F., Neves, N. M., & Reis, R. L. (2003) · Composites Science and Technology · doi:10.1016/j.compscitech.2003.09.001 · Cited by 449 · see citing works
Recent developments in biodegradable synthetic polymers
Gunatillake, P. A., Mayadunne, R. T. A., & Adhikari, R. (2006) · Biotechnology annual review · doi:10.1016/s1387-2656(06)12009-8 · Cited by 446 · see citing works
Formation of highly porous biodegradable scaffolds for tissue engineering
Mikos, A. G., & Temenoff, J. S. (2000) · Electronic Journal of Biotechnology · doi:10.2225/vol3-issue2-fulltext-5 · Cited by 427 · see citing works
Self-citation
Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications
Liu, S., Yu, J.-M., Gan, Y.-C., Qiu, X.-Z., Gao, Z.-C., Wang, H., Chen, S.-X., Xiong, Y., Liu, G.-H., Lin, S.-E., et al. (2023) · Military Medical Research · doi:10.1186/s40779-023-00448-w · Cited by 357 · see citing works
Biomaterials for intervertebral disc regeneration and repair
Bowles, R. D., & Setton, L. A. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.013 · Cited by 345 · see citing works
Geometry as a Factor for Tissue Growth: Towards Shape Optimization of Tissue Engineering Scaffolds
Bidan, C. M., Kommareddy, K. P., Rumpler, M., Kollmannsberger, P., Fratzl, P., & Dunlop, J. (2012) · Advanced Healthcare Materials · doi:10.1002/adhm.201200159 · Cited by 341 · see citing works
New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers
Vasile, C., Pamfil, D., Stoleru, E., & Baican, M. C. (2020) · Molecules · doi:10.3390/molecules25071539 · Cited by 341 · see citing works
A review of materials, fabrication methods, and strategies used to enhance bone regeneration in engineered bone tissues
Stevens, B., Yang, Y., Mohandas, A., Stucker, B. E., & Nguyen, K. T. (2007) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.30962 · Cited by 326 · see citing works
Engineering Structurally Organized Cartilage and Bone Tissues
Sharma, B., & Elisseeff, J. H. (2003) · Annals of Biomedical Engineering · doi:10.1023/b:abme.0000007799.60142.78 · Cited by 322 · see citing works
Calcium orthophosphate-based biocomposites and hybrid biomaterials
Dorozhkin, S. V. (2009) · Journal of Materials Science · doi:10.1007/s10853-008-3124-x · Cited by 300 · see citing works
Injectable scaffolds for tissue regeneration
Hou, Q., Bank, P. D., & Shakesheff, K. M. (2004) · Journal of Materials Chemistry · doi:10.1039/b401791a · Cited by 302 · see citing works
Synthesis and in Vitro Evaluation of Enzymatically Cross-Linked Elastin-Like Polypeptide Gels for Cartilaginous Tissue Repair
McHale, M. K., Setton, L. A., & Chilkoti, A. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.1768 · Cited by 296 · see citing works
Delivery of TGF-β1 and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications
Park, H., Temenoff, J. S., Holland, T. A., Tabata, Y., & Mikos, A. G. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.05.083 · Cited by 293 · see citing works
Self-citation
Degradable thiol-acrylate photopolymers: polymerization and degradation behavior of an in situ forming biomaterial
Rydholm, A. E., Bowman, C. N., & Anseth, K. S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.11.046 · Cited by 290 · see citing works
A review of the recent trends on core structures and impact response of sandwich panels
Ma, Q., Rejab, M. R. M., Siregar, J. P., & Guan, Z. (2021) · Journal of Composite Materials · doi:10.1177/0021998321990734 · Cited by 260 · see citing works
Calcium phosphate-alginate microspheres as enzyme delivery matrices
Ribeiro, C. C., Barrias, C. C., & Barbosa, M. A. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2003.11.028 · Cited by 255 · see citing works
Biocompatibility of Subcutaneously Implanted Plant-Derived Cellulose Biomaterials
Modulevsky, D. J., Cuerrier, C. M., & Pelling, A. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157894 · Cited by 254 · see citing works
Injectable scaffolds: Preparation and application in dental and craniofacial regeneration
Chang, B., Ahuja, N., Ma, C., & Liu, X. (2016) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2016.11.001 · Cited by 252 · see citing works
Mineralization of Hydrogels for Bone Regeneration
Gkioni, K., Leeuwenburgh, S. C. G., Douglas, T., Mikos, A. G., & Jansen, J. A. (2010) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2010.0462 · Cited by 244 · see citing works
Self-citation
A review on injectable chitosan/beta glycerophosphate hydrogels for bone tissue regeneration
Sekaran, S., Vimalraj, S., Thanikaivelan, P., Banudevi, S., & Manivasagam, G. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.10.014 · Cited by 239 · see citing works
Covalently crosslinked chitosan hydrogel: Properties of in vitro degradation and chondrocyte encapsulation
Hong, Y., Song, H., Gong, Y., Mao, Z., Gao, C., & Shen, J. (2006) · Acta Biomaterialia · doi:10.1016/j.actbio.2006.06.007 · Cited by 238 · see citing works
Cartilage Tissue Engineering: Towards a Biomaterial-Assisted Mesenchymal Stem Cell Therapy
Vinatier, C. S., Bouffi, C., Merceron, C., Gordeladze, J. O., Brondello, J., Jørgensen, C., Weiss, P., Guicheux, J., & Noël, D. (2009) · Current Stem Cell Research & Therapy · doi:10.2174/157488809789649205 · Cited by 236 · see citing works
Alternative tissue engineering scaffolds based on starch: processing methodologies, morphology, degradation and mechanical properties
Gomes, M. E., Godinho, J. S., Tchalamov, D., Cunha, A. M., & Reis, R. L. (2002) · Materials Science and Engineering C · doi:10.1016/s0928-4931(02)00008-5 · Cited by 233 · see citing works
Accelerated chondrocyte functions on NaOH-treated PLGA scaffolds
Park, G. E., Pattison, M. A., Park, K., & Webster, T. J. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.08.005 · Cited by 232 · see citing works
Materials of marine origin: a review on polymers and ceramics of biomedical interest
Silva, T. H., Alves, A., Ferreira, B., Oliveira, J. M., Reys, L. L., Ferreira, R. J. F., Sousa, R. A., Silva, S. S., Mano, J. F., & Reis, R. L. (2012) · International Materials Reviews · doi:10.1179/1743280412y.0000000002 · Cited by 232 · see citing works
Functional cellulose-based hydrogels as extracellular matrices for tissue engineering
Dutta, S. D., Patel, D. K., & Lim, K. (2019) · Journal of Biological Engineering · doi:10.1186/s13036-019-0177-0 · Cited by 230 · see citing works
Biodegradable Polymer Scaffolds for Cartilage Tissue Engineering
Lu, L., Zhu, X., Valenzuela, R. G., Currier, B. L., & Yaszemski, M. J. (2001) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-200110001-00024 · Cited by 228 · see citing works
Porous Biodegradable Metals for Hard Tissue Scaffolds: A Review
Yusop, A. H. M., Bakir, A. A., Shaharom, N. A., Kadir, M. R. A., & Hermawan, H. (2012) · International Journal of Biomaterials · doi:10.1155/2012/641430 · Cited by 226 · see citing works
Engineering of Vascularized Transplantable Bone Tissues: Induction of Axial Vascularization in an Osteoconductive Matrix Using an Arteriovenous Loop
Kneser, U., Polykandriotis, E., Ohnolz, J., Heidner, K., Grabinger, L., Euler, S. A., Amann, K., Heß, A., Brune, K., Greil, P., et al. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.1721 · Cited by 221 · see citing works
In vitro release of transforming growth factor-β1 from gelatin microparticles encapsulated in biodegradable, injectable oligo(poly(ethylene glycol) fumarate) hydrogels
Holland, T. A., Tabata, Y., & Mikos, A. G. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00258-x · Cited by 218 · see citing works
Self-citation
Photocrosslinking characteristics and mechanical properties of diethyl fumarate/poly(propylene fumarate) biomaterials
Fisher, J. P., Dean, D., & Mikos, A. G. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00178-3 · Cited by 216 · see citing works
Self-citation
Magnesium Phosphate Cement Systems for Hard Tissue Applications: A Review
Ostrowski, N. J., Roy, A., & Kumta, P. N. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00056 · Cited by 215 · see citing works
Synthesis and evaluation of injectable, in situ crosslinkable synthetic extracellular matrices for tissue engineering
Shu, X. Z., Ahmad, S., Liu, Y., & Prestwich, G. D. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30831 · Cited by 209 · see citing works
Tissue-engineered Neogenesis of Human-shaped Mandibular Condyle from Rat Mesenchymal Stem Cells
Alhadlaq, A., & Mao, J. J. (2003) · Journal of Dental Research · doi:10.1177/154405910308201203 · Cited by 199 · see citing works
Photopolymers for rapid prototyping
Liska, R., Schuster, M., Inführ, R., Turecek, C., Fritscher, C., Seidl, B., Schmidt, V., Kuna, L., Haase, A., Varga, F., et al. (2007) · Journal of Coatings Technology and Research · doi:10.1007/s11998-007-9059-3 · Cited by 199 · see citing works
Biocomposites and hybrid biomaterials based on calcium orthophosphates
Dorozhkin, S. V. (2011) · Biomatter · doi:10.4161/biom.1.1.16782 · Cited by 198 · see citing works
Injectable immunomodulation-based porous chitosan microspheres/HPCH hydrogel composites as a controlled drug delivery system for osteochondral regeneration
Ji, X., Shao, H., Li, X., Ullah, M. W., Luo, G., Xu, Z., Ma, L., He, X., Lei, Z., Ma, Q., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121530 · Cited by 195 · see citing works
Basic Principles of Emulsion Templating and Its Use as an Emerging Manufacturing Method of Tissue Engineering Scaffolds
Dikici, B. A., & Claeyssens, F. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00875 · Cited by 187 · see citing works
Polymers for medical and tissue engineering applications
Ozdil, D., & Aydın, H. M. (2014) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.4505 · Cited by 179 · see citing works
Electrospinning: processing technique for tissue engineering scaffolding
Martins, A. M., Reis, R. L., & Neves, N. M. (2008) · International Materials Reviews · doi:10.1179/174328008x353547 · Cited by 173 · see citing works
Gelation time and degradation rate of chitosan-based injectable hydrogel
Ganji, F., Abdekhodaie, M. J., & A., A. R. S. (2007) · Journal of Sol-Gel Science and Technology · doi:10.1007/s10971-006-9007-1 · Cited by 169 · see citing works
Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications
Dorozhkin, S. V. (2015) · Journal of Functional Biomaterials · doi:10.3390/jfb6030708 · Cited by 169 · see citing works
Citric acid-derived in situ crosslinkable biodegradable polymers for cell delivery
Gyawali, D., Nair, P., Zhang, Y. L., Tran, R. T., Zhang, C., Samchukov, M. L., Makarov, M. R., Kim, H. K. W., & Yang, J. Y. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.022 · Cited by 167 · see citing works
Solvent induced phase inversion-based in situ forming controlled release drug delivery implants
Singh, T. R. R., McMillan, H. L., & Jones, D. S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.12.020 · Cited by 166 · see citing works
Synthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates
Guelcher, S. A., Srinivasan, A., Dumas, J. E., Didier, J. E., McBride, S., & Hollinger, J. O. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.12.046 · Cited by 166 · see citing works
Acrylic acid grafting and collagen immobilization on poly(ethylene terephthalate) surfaces for adherence and growth of human bladder smooth muscle cells
Bisson, I., Kosinski, M., Ruault-Jungblut, S., Gupta, B., Hilborn, J. G., Wurm, F. M., & Frey, P. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00061-3 · Cited by 164 · see citing works
Novel Starch-Based Scaffolds for Bone Tissue Engineering: Cytotoxicity, Cell Culture, and Protein Expression
Salgado, A. J., Coutinho, O. P., & Reis, R. L. (2004) · Tissue Engineering · doi:10.1089/107632704323061825 · Cited by 162 · see citing works
Injectable and tunable hyaluronic acid hydrogels releasing chemotactic and angiogenic growth factors for endodontic regeneration
Silva, C. R., Babo, P. S., Gulino, M., Costa, L., Oliveira, J. M., Silva‐Correia, J., Domingues, R. M. A., Reis, R. L., & Gomes, M. E. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.07.035 · Cited by 162 · see citing works
Synthesis of two-component injectable polyurethanes for bone tissue engineering
Bonzani, I. C., Adhikari, R., Houshyar, S., Mayadunne, R., Gunatillake, P., & Stevens, M. M. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.08.026 · Cited by 159 · see citing works
Self-healing polysaccharide-based hydrogels as injectable carriers for neural stem cells
Zhao, W., Zhao, J., Chen, Y. M., Zhang, P., & Zhang, Q. (2016) · Scientific Reports · doi:10.1038/srep37841 · Cited by 159 · see citing works
PEG‐Grafted Chitosan as an Injectable Thermoreversible Hydrogel
Bhattarai, N., Matsen, F. A., & Zhang, M. (2005) · Macromolecular Bioscience · doi:10.1002/mabi.200400140 · Cited by 156 · see citing works
Tungsten disulfide nanotubes reinforced biodegradable polymers for bone tissue engineering
Lalwani, G., Henslee, A. M., Farshid, B., Parmar, P., Lin, L., Qin, Y., Kasper, F. K., Mikos, A. G., & Sitharaman, B. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.05.018 · Cited by 153 · see citing works
Self-citation
Biodegradable Fumarate-Based PolyHIPEs as Tissue Engineering Scaffolds
Christenson, E. M., Soofi, W., Holm, J. L., Cameron, N. R., & Mikos, A. G. (2007) · Biomacromolecules · doi:10.1021/bm7007235 · Cited by 152 · see citing works
Self-citation
Polymeric Biomaterials for Scaffold-Based Bone Regenerative Engineering
Ogueri, K. S., Jafari, T., Ivirico, J. L. E., & Laurencin, C. T. (2018) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-018-0072-0 · Cited by 153 · see citing works
Hydrogels: An overview of its classifications, properties, and applications
Mehta, P., Sharma, M., & Devi, M. (2023) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2023.106145 · Cited by 155 · see citing works
Upregulation of bone cell differentiation through immobilization within a synthetic extracellular matrix
Evangelista, M. B., Hsiong, S. X., Fernandes, R., Sampaio, P., Kong, H., Barrias, C. C., Salema, R., Barbosa, M. A., Mooney, D. J., & Granja, P. L. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.04.028 · Cited by 149 · see citing works
N-succinyl chitosan–dialdehyde starch hybrid hydrogels for biomedical applications
Kamoun, E. A. (2015) · Journal of Advanced Research · doi:10.1016/j.jare.2015.02.002 · Cited by 143 · see citing works
Expansion of human nasal chondrocytes on macroporous microcarriers enhances redifferentiation
Malda, J., Kreijveld, E., Temenoff, J. S., van Blitterswijk, C., & Riesle, J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00428-9 · Cited by 143 · see citing works
Self-citation
Immobilization of Human Mesenchymal Stem Cells within RGD-Grafted Alginate Microspheres and Assessment of Their Angiogenic Potential
Bidarra, S. J., Barrias, C. C., Barbosa, M. A., Soares, R. A., & Granja, P. L. (2010) · Biomacromolecules · doi:10.1021/bm100264a · Cited by 142 · see citing works
A survey of fabrication and application of metallic foams (1925–2017)
Singh, S., & Bhatnagar, N. (2017) · Journal of Porous Materials · doi:10.1007/s10934-017-0467-1 · Cited by 142 · see citing works
Biodegradability and biocompatibility of a pH- and thermo-sensitive hydrogel formed from a sulfonamide-modified poly(ε-caprolactone-co-lactide)–poly(ethylene glycol)–poly(ε-caprolactone-co-lactide) block copolymer
Shim, W. S., Kim, J.-H., Park, H., Kim, K., Kwon, I. C., & Lee, D. S. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.05.038 · Cited by 141 · see citing works
Fabrication and Characterization of Poly(Propylene Fumarate) Scaffolds with Controlled Pore Structures Using 3-Dimensional Printing and Injection Molding
Lee, K., Wang, S., Lu, L., Jabbari, E., Currier, B. L., & Yaszemski, M. J. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.2801 · Cited by 140 · see citing works
Fabrication of micro/nanoporous collagen/dECM/silk-fibroin biocomposite scaffolds using a low temperature 3D printing process for bone tissue regeneration
Lee, H., Yang, G. H., Kim, M., Lee, J., Huh, J., & Kim, G. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.11.013 · Cited by 139 · see citing works
Covalently polysaccharide-based alginate/chitosan hydrogel embedded alginate microspheres for BSA encapsulation and soft tissue engineering
Xing, L., Sun, J., Tan, H., Yuan, G., Li, J., Yang, J., Xiong, D., Chen, G., Lai, J., Ling, Z., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.01.065 · Cited by 138 · see citing works
Manipulations in Hydrogel Degradation Behavior Enhance Osteoblast Function and Mineralized Tissue Formation
Benoit, D. S. W., Durney, A. R., & Anseth, K. S. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.1663 · Cited by 136 · see citing works
Biodegradable Polymers
Zhang, Z., Ortiz, O., Goyal, R., & Kohn, J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-323-22805-3.00013-x · Cited by 136 · see citing works
Injectable Functional Biomaterials for Minimally Invasive Surgery
Raucci, M. G., D’Amora, U., Ronca, A., & Ambrosio, L. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000349 · Cited by 136 · see citing works
Development of bone substitute materials: from ‘biocompatible’ to ‘instructive’
Bongio, M., van den Beucken, J. J. J. P., Leeuwenburgh, S. C. G., & Jansen, J. A. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm00795a · Cited by 136 · see citing works
Autologous Injectable Tissue-Engineered Cartilage by Using Platelet-Rich Plasma: Experimental Study in a Rabbit Model
Wu, W. T., Chen, F., Liu, Y., Ma, Q., & Mao, T. (2007) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2006.11.044 · Cited by 135 · see citing works
Injectable cartilage tissue engineering
Elisseeff, J. H. (2004) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.4.12.1849 · Cited by 134 · see citing works
Poly(propylene fumarate)-based materials: Synthesis, functionalization, properties, device fabrication and biomedical applications
Cai, Z., Wan, Y., Becker, M. L., Long, Y.-Z., & Dean, D. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.03.038 · Cited by 133 · see citing works
The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives
Eftekhari, A., Dizaj, S. M., Sharifi, S., Salatin, S., Saadat, Y. R., Vahed, S. Z., Samiei, M., Ardalan, M., Rameshrad, M., Ahmadian, E., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020536 · Cited by 132 · see citing works
In vitro osteogenic differentiation of marrow stromal cells encapsulated in biodegradable hydrogels
Temenoff, J. S., Park, H., Jabbari, E., Sheffield, T. L., LeBaron, R. G., Ambrose, C. G., & Mikos, A. G. (2004) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30064 · Cited by 132 · see citing works
Self-citation
In vitro degradation of polymeric networks of poly(propylene fumarate) and the crosslinking macromer poly(propylene fumarate)-diacrylate
Timmer, M. D. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00368-x · Cited by 130 · see citing works
Injectable Biodegradable Polyurethane Scaffolds with Release of Platelet-derived Growth Factor for Tissue Repair and Regeneration
Hafeman, A. E., Li, B. J., Yoshii, T., Zienkiewicz, K. J., Davidson, J. M., & Guelcher, S. A. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9618-z · Cited by 130 · see citing works

Injectable Biodegradable Materials for Orthopaedic Tissue Engineering
Temenoff, J. S., & Mikos, A. G. (2002) · Springer eBooks · doi:10.1007/978-94-010-0305-6_16 · Cited by 7 · see citing works
Self-citation
Biodegradable injectable systems for bone tissue engineering
Tran, R. T., Gyawali, D., Nair, P., & Yang, J. Y. (2011) · Cited by 9 · see citing works
Investigation of potential injectable polymeric biomaterials for bone regeneration
Dreifke, M. B., Ebraheim, N. A., & Jayasuriya, A. C. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34521 · Cited by 118 · see citing works
Biomedical Applications of Injectable Inorganic Biomaterials
Jinwen, W. A. N. G., Zhen, Y. A. N. G., Huan, Z. H. O. U., Dan, X. I. A., & Yang, L. (2026) · Journal of Inorganic Materials · doi:10.15541/jim20250441
Biocompatibility of injectable materials
Guelcher, S. A. (2011) · Elsevier eBooks · doi:10.1533/9780857091376.3.354 · Cited by 3 · see citing works

Authors: Temenoff, J. S., & Mikos, A. G.
Affiliations: Rice University (US)
Corresponding author: Mikos, Antonios G
ORCID: Temenoff, Johnna S
Mikos, Antonios G
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2000-12
Volume: 21
Issue: 23
Pages: 2405-2412
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/s0142-9612(00)00108-3
OpenAlex: W2062224667
Cited by: 554
References: 71
Citations by year: 2026: 4 · 2025: 6 · 2024: 5 · 2023: 12 · 2022: 10 · 2021: 13 · 2020: 19 · 2019: 20 · 2018: 18 · 2017: 26 · 2016: 29 · 2015: 24 · 2014: 34 · 2013: 24 · 2012: 32
FWCI: 12.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Funders: Badan Riset dan Inovasi Nasional
National Institutes of Health (5r01ar044381-04, 5r01de013031-05)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR44381)
National Institute of Dental and Craniofacial Research (R01 DE13031)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords: orthopedic tissue engineering, bone regeneration, cartilage regeneration, biocompatibility, mechanical properties, ceramic scaffolds, natural polymers, synthetic polymers, tissue regeneration
MeSH terms: Animals, Biocompatible Materials, Biodegradation, Environmental, Bone and Bones, Cartilage, Orthopedics, Rabbits, Rats

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Injectable biodegradable materials for orthopedic tissue engineering

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