The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo
Open accessAbstract
A small library of arylthioamides 1-12 was easily synthesized, and their H2S-releasing properties were evaluated both in the absence or in the presence of an organic thiol such as l-cysteine. A number of arylthioamides (1-3 and 7) showed a slow and l-cysteine-dependent H2S-releasing mechanism, similar to that exhibited by the reference slow H2S-releasing agents, such as diallyl disulfide (DADS) and the phosphinodithioate derivative GYY 4137. Compound 1 strongly abolished the noradrenaline-induced vasoconstriction in isolated rat aortic rings and hyperpolarized the membranes of human vascular smooth muscle cells in a concentration-dependent fashion. Finally, a significant reduction of the systolic blood pressure of anesthetized normotensive rats was observed after its oral administration. Altogether these results highlighted the potential of arylthioamides 1-3 and 7 as H2S-donors for basic studies, and for the rational design/development of promising pharmacotherapeutic agents to treat cardiovascular diseases.
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Cites
H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Yang, G., Wu, L., Jiang, B., Yang, W., Qi, J., Cao, K., Meng, Q., Mustafa, A. K., Mu, W., Zhang, S., et al. (2008) · Science · doi:10.1126/science.1162667 · Cited by 2,310
Cited by
Chemical Biology of H2S Signaling through Persulfidation
Filipovic, M. R., Zivanovic, J., Alvarez, B., & Banerjee, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00205 · Cited by 1,046
A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications
Powell, C. R., Dillon, K. M., & Matson, J. B. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.11.014 · Cited by 599
Szabo, C., & Papapetropoulos, A. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.014050 · Cited by 423
Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications
Zhao, Y., Biggs, T. D., & Xian, M. (2014) · Chem. Commun. · doi:10.1039/c4cc00968a · Cited by 358
l‐Cysteine metabolism and its nutritional implications
Yin, J., Ren, W., Yang, G., Duan, J., Huang, X., Fang, R., Li, C., Li, T., Yin, Y., Hou, Y., et al. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500031 · Cited by 353
Metadata
- Authors
- Martelli, A., Testai, L., Citi, V., Marino, A., Pugliesi, I., Barresi, E., Nesi, G., Rapposelli, S., Taliani, S., Da Settimo, F., Breschi, M. C., & Calderone, V.
- Venue
- ACS Medicinal Chemistry Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-08-12
- Volume
- 4
- Issue
- 10
- Pages
- 904-908
- ISSN
- 1948-5875 (ISSN-L)
- OpenAlex
- W1973549188
- Cited by
- 179
- References
- 1
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Martelli, A., Testai, L., Citi, V., Marino, A., Pugliesi, I., Barresi, E., Nesi, G., Rapposelli, S., Taliani, S., Da Settimo, F., Breschi, M. C., & Calderone, V. (2013). Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo. ACS Medicinal Chemistry Letters. https://doi.org/10.1021/ml400239a
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