Targeted delivery of cargoes into a murine solid tumor by a cell-penetrating peptide and cleavable poly(ethylene glycol) comodified liposomal delivery system via systemic administration
Abstract
A liposomal delivery system with a high efficiency of accumulation in tumor tissue and then transportation of the cargo into tumor cells was developed here and evaluated via systemic administration. 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol)(2000) (DSPE-PEG(2000))-TAT and protective DSPE-PEG(2000) modified liposomes possessing good stability in 50% FBS (fetal bovine serum) and good uptake efficiency were used as the basic formulation (TAT-SL; SL = stealth liposome), and then longer cysteine (Cys)-cleavable PEG(5000) was incorporated to modulate the function of TAT. All of the formulations to be used in vivo had sizes in a range of 80-100 nm and were stable in the presence of 50% FBS. Optical imaging showed that the incorporation of cleavable PEG(5000) into TAT-SL (i.e., C-TAT-SL) led to much more tumor accumulation and much less liver distribution compared with TAT-SL. The in vivo delivery profiles of C-TAT-SL were investigated using DiD as a fluorescent probe. Confocal laser scanning microscopy and flow cytometry showed that C-TAT-SL had a 48% higher (p < 0.001) delivery efficiency in the absence of Cys and a 130% higher (p < 0.001) delivery efficiency in the presence of Cys than the control (SL), indicating the successful targeted delivery of cargo was achieved by C-TAT-SL via systemic administration especially with a subsequent administration of Cys.
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Environmental stimuli-triggered detachment may be feasible solution to decreased cellular uptake after PEGylation.
“Like other gene therapy strategies, environmental stimuli-triggered detachment may be a feasible solution to this problem [146].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [146]
Cites
Active targeting schemes for nanoparticle systems in cancer therapeutics
Byrne, J. D., Betancourt, T., & Brannon‐Peppas, L. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.08.005 · Cited by 1,732 · see citing works
Saito, G., Swanson, J. A., & Lee, K.-D. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00179-5 · Cited by 1,407 · see citing works
Kirpotin, D. B., Drummond, D. C., Shao, Y., Shalaby, M. R., Hong, K., Nielsen, U. B., Marks, J. D., Benz, C. C., & Park, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4199 · Cited by 1,129 · see citing works
Targeting nanoparticles to cancer
Wang, M., & Thanou, M. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.03.005 · Cited by 928 · see citing works
Torchilin, V. P., Rammohan, R., Weissig, V., & Levchenko, T. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151247498 · Cited by 777 · see citing works
Targeted pharmaceutical nanocarriers for cancer therapy and imaging
Torchilin, V. P. (2007) · The AAPS Journal · doi:10.1208/aapsj0902015 · Cited by 758 · see citing works
Cancer nanotechnology: application of nanotechnology in cancer therapy
Misra, R., Acharya, S., & Sahoo, S. K. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.08.006 · Cited by 701 · see citing works
Stealth nanoparticles: High density but sheddable PEG is a key for tumor targeting
Li, S., & Huang, L. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.03.016 · Cited by 562 · see citing works
Sheddable Coatings for Long-Circulating Nanoparticles
Romberg, B., Hennink, W. E., & Storm, G. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9348-7 · Cited by 554 · see citing works
Tumour-targeted nanomedicines: principles and practice
Lammers, T., Hennink, W. E., & Storm, G. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604483 · Cited by 542 · see citing works
“SMART” Drug Delivery Systems: Double-Targeted pH-Responsive Pharmaceutical Nanocarriers
Sawant, R. M., Hurley, J. P., Salmaso, S., Kale, A., Tolcheva, E., Levchenko, T. S., & Torchilin, V. P. (2006) · Bioconjugate Chemistry · doi:10.1021/bc060080h · Cited by 540 · see citing works
Nanoparticles evading the reticuloendothelial system: Role of the supported bilayer
Li, S., & Huang, L. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.06.022 · Cited by 487 · see citing works
Extracellularly Activated Nanocarriers: A New Paradigm of Tumor Targeted Drug Delivery
Gullotti, E., & Yeo, Y. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900090z · Cited by 471 · see citing works
Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers
Torchilin, V. P. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.10.008 · Cited by 449 · see citing works
Cell-penetrating and cell-targeting peptides in drug delivery
Vivès, É., Schmidt, J., & Pèlegrin, A. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.03.001 · Cited by 442 · see citing works
Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome–DNA complexes
Torchilin, V. P., Levchenko, T. S., Rammohan, R., Volodina, N., Papahadjopoulos‐Sternberg, B., & D’Souza, G. G. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0435906100 · Cited by 419 · see citing works
Hatakeyama, H., Akita, H., Kogure, K., Oishi, M., Nagasaki, Y., Kihira, Y., Ueno, M., Kobayashi, H., Kikuchi, H., & Harashima, H. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302843 · Cited by 397 · see citing works
Santos, N. D., Allen, C. J., Doppen, A.-M., Anantha, M., Cox, K. A. K., Gallagher, R. C., Karlsson, G., Edwards, K., Kenner, G. S., Samuels, L., et al. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.12.013 · Cited by 340 · see citing works
Zhang, C., Liu, T., Su, Y., Luo, S., Zhu, Y., Tan, X., Fan, S., Zhang, L., Zhou, Y., Cheng, T., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.007 · Cited by 270 · see citing works
Hatakeyama, H., Ito, E., Akita, H., Oishi, M., Nagasaki, Y., Futaki, S., & Harashima, H. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.06.008 · Cited by 255 · see citing works
Siegal, T., Horowitz, A., & Gabizon, A. (1995) · Journal of neurosurgery · doi:10.3171/jns.1995.83.6.1029 · Cited by 232 · see citing works
Hong, R. L., Huang, C. J., Tseng, Y., Pang, V. F., Chen, S.-T., Liu, J. J., & Chang, F. (1999) · PubMed · Cited by 227 · see citing works
Gabizón, A., Goren, D., Horowitz, A. T., Tzemach, D., Lossos, A., & Siegal, T. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(96)00476-0 · Cited by 220 · see citing works
Terada, T., Iwai, M., Kawakami, S., Yamashita, F., & Hashida, M. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.12.023 · Cited by 197 · see citing works
Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo
Song, S., Liu, D., Peng, J., Sun, Y., Li, Z., Gu, J., & Xu, Y. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.07.012 · Cited by 180 · see citing works
Kale, A. A., & Torchilin, V. P. (2007) · Journal of drug targeting · doi:10.1080/10611860701498203 · Cited by 159 · see citing works
McNeeley, K. M., Karathanasis, E., Annapragada, A., & Bellamkonda, R. V. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.04.012 · Cited by 137 · see citing works
Tumor targeting of functionalized lipid nanoparticles: Assessment by in vivo fluorescence imaging
Goutayer, M., Dufort, S., Josserand, V., Royère, A., Heinrich, E., Vinet, F., Bibette, J., Coll, J., & Texier, I. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.02.007 · Cited by 135 · see citing works
Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome
Maeda, N., Takeuchi, Y., Takada, M., Sadzuka, Y., Namba, Y., & Oku, N. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.07.033 · Cited by 123 · see citing works
In vivo fluorescence imaging: a personal perspective
Ghoroghchian, P. P., Therien, M. J., & Hammer, D. A. (2009) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.7 · Cited by 112 · see citing works
Xu, H., Deng, Y., Chen, D., HONG, W., Lu, Y., & Dong, X. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.05.009 · Cited by 109 · see citing works
Kuai, R., Yuan, W., Qin, Y., Chen, H., Tang, J., Yuan, M., Zhang, Z., & He, Q. (2010) · Molecular Pharmaceutics · doi:10.1021/mp100171c · Cited by 108 · see citing works
OVCAR-3 cells internalize TAT-peptide modified liposomes by endocytosis
Fretz, M. M., Koning, G. A., Mastrobattista, E., Jiskoot, W., & Storm, G. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.06.022 · Cited by 108 · see citing works
PEGylated and MMP-2 Specifically DePEGylated Quantum Dots: Comparative Evaluation of Cellular Uptake
Mok, H., Bae, K. H., Ahn, C., & Park, T. G. (2008) · Langmuir · doi:10.1021/la803542v · Cited by 99 · see citing works
Ogawara, K., Un, K., Minato, K., Tanaka, K.-I., Higaki, K., & Kimura, T. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.03.025 · Cited by 89 · see citing works
Chang, Y., Chang, C.-H., Yu, C., Chang, T., Chen, L., Chen, M., Lee, T., & Ting, G. (2009) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2009.08.006 · Cited by 80 · see citing works
Cellular entry pathway and gene transfer capacity of TAT-modified lipoplexes
Vandenbroucke, R. E., Smedt, S. C. D., Demeester, J., & Sanders, N. N. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.11.006 · Cited by 69 · see citing works
Cryan, S., Devocelle, M. C., Moran, P. J., Hickey, A. J., & Kelly, J. G. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050070i · Cited by 64 · see citing works
Maeda, T., & Fujimoto, K. (2006) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2006.02.006 · Cited by 63 · see citing works
Lila, A. S. A., Doi, Y., Nakamura, K., Ishida, T., & Kiwada, H. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.10.020 · Cited by 55 · see citing works
Improved transfection of spleen-derived antigen-presenting cells in culture using TATp-liposomes
Pappalardo, J. S., Quattrocchi, V., Langellotti, C. A., Giacomo, S. D., Gnazzo, V., Olivera, V., Calamante, G., Zamorano, P. I., Levchenko, T. S., & Torchilin, V. P. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.11.006 · Cited by 43 · see citing works
Long-circulating poly(ethylene glycol)-coated emulsions to target solid tumors
Rossi, J., Giasson, S., Khalid, M. N., Delmas, P., Allen, C. J., & Leroux, J. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.03.016 · Cited by 35 · see citing works
Combined electric field and ultrasound therapy as a novel anti-tumour treatment
Larkin, J., Soden, D. M., Collins, C. G., Tangney, M., Preston, J. R., Russell, L. J., McHale, A. P., Dunne, C. P., & O’Sullivan, G. C. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.01.025 · Cited by 22 · see citing works
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Sorted by citations
Cell-penetrating peptides: breaking through to the other side
Koren, E., & Torchilin, V. P. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.04.012 · Cited by 671 · see citing works
Ligand-targeted liposome design: challenges and fundamental considerations
Noble, G. T., Stefanick, J. F., Ashley, J. D., Kiziltepe, T., & Bilgiçer, B. (2013) · Trends in biotechnology · doi:10.1016/j.tibtech.2013.09.007 · Cited by 546 · see citing works
Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities
Li, L., Hu, S., & Chen, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.031 · Cited by 415 · see citing works
Application of Light Scattering Techniques to Nanoparticle Characterization and Development
Carvalho, P. M., Felício, M. R., Santos, N. C., Gonçalves, S., & Domingues, M. M. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00237 · Cited by 402 · see citing works
Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery
Fang, Y., Xue, J., Gao, S., Lu, A., Yang, D., Jiang, H., He, Y., & Shi, K. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1388451 · Cited by 388 · see citing works
Cell Penetrating Peptides as Molecular Carriers for Anti-Cancer Agents
Borrelli, A., Tornesello, A. L., Tornesello, M. L., & Buonaguro, F. M. (2018) · Molecules · doi:10.3390/molecules23020295 · Cited by 296 · see citing works
Liposomes in Cancer Therapy: How Did We Start and Where Are We Now
Fulton, M. D., & Najahi‐Missaoui, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076615 · Cited by 270 · see citing works
Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting
Perche, F., & Torchilin, V. P. (2013) · Journal of Drug Delivery · doi:10.1155/2013/705265 · Cited by 232 · see citing works
Effect of surface properties on liposomal siRNA delivery
Xia, Y., Tian, J., & Chen, X. S. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.056 · Cited by 223 · see citing works
Peptide Targeted Lipid Nanoparticles for Anticancer Drug Delivery
Pearce, T. R., Shroff, K., & Kokkoli, E. (2012) · Advanced Materials · doi:10.1002/adma.201200832 · Cited by 195 · see citing works
A pH-responsive α-helical cell penetrating peptide-mediated liposomal delivery system
Zhang, Q., Tang, J., Fu, L., Ran, R., Liu, Y., Yuan, M., & He, Q. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.014 · Cited by 171 · see citing works
Gao, H., & He, Q. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.877442 · Cited by 166 · see citing works
Targeted Delivery of Nano-Therapeutics for Major Disorders of the Central Nervous System
Gao, H., Pang, Z., & Jiang, X. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1122-4 · Cited by 164 · see citing works
Gao, H., Zhang, S., Cao, S., Yang, Z. H., Pang, Z., & Jiang, X. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500113p · Cited by 155 · see citing works
Surface modification of lipid-based nanocarriers for cancer cell-specific drug targeting
Kim, C. H., Lee, S. G., Kang, M. J., Lee, S. K., & Choi, Y. W. (2017) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-017-0329-5 · Cited by 144 · see citing works
CRISPR/Cas9 gene editing: New hope for Alzheimer's disease therapeutics
Bhardwaj, S., Kesari, K. K., Rachamalla, M., Mani, S., Ashraf, G. M., Jha, S. K., Kumar, P., Ambasta, R. K., Dureja, H., Devkota, H. P., et al. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.07.001 · Cited by 145 · see citing works
Stimulus-responsive liposomes for biomedical applications
Antoniou, A. I., Giofrè, S., Seneci, P., Passarella, D., & Pellegrino, S. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.05.010 · Cited by 135 · see citing works
Enzyme-triggered, cell penetrating peptide-mediated delivery of anti-tumor agents
He, H., Sun, L., Ye, J., Liu, E., Chen, S., Liang, Q., Shin, M. C., & Yang, V. C.-M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.10.040 · Cited by 111 · see citing works
Liu, Y., Mei, L., Xu, C., Yu, Q., Shi, K., Zhang, L., Wang, Y., Zhang, Q., Gao, H., Zhang, Z., et al. (2015) · Theranostics · doi:10.7150/thno.13532 · Cited by 112 · see citing works
Sikorski, A. F., Toporkiewicz, M., Meissner, J. M., Matusewicz, L., & Czogalla, A. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s74514 · Cited by 104 · see citing works
Mei, L., Fu, L., Shi, K., Zhang, Q., Liu, Y., Tang, J., Gao, H., Zhang, Z., & He, Q. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.04.008 · Cited by 103 · see citing works
CPP-Assisted Intracellular Drug Delivery, What Is Next?
Ye, J., Liu, E., Yu, Z., Pei, X., Chen, S., Zhang, P., Shin, M. C., Gong, J., He, H., & Yang, V. C.-M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17111892 · Cited by 93 · see citing works
Fu, H., Shi, K., Hu, G., Yang, Y., Kuang, Q., Lu, L., Zhang, L., Chen, W., Dong, M., Chen, Y., et al. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24291 · Cited by 88 · see citing works
Cell-penetrating Peptide-based Intelligent Liposomal Systems for Enhanced Drug Delivery
Gao, H., Zhang, Q., Yu, Z., & He, Q. (2014) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201015666140617092552 · Cited by 87 · see citing works
Tang, J., Zhang, L., Gao, H., Liu, Y., Zhang, Q., Ran, R., Zhang, Z., & He, Q. (2014) · Drug Delivery · doi:10.3109/10717544.2014.990651 · Cited by 80 · see citing works
Yue, J., Liu, S., Wang, R., Hu, X., Xie, Z., Huang, Y., & Jing, X. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300213g · Cited by 77 · see citing works
Hu, W. S., Qiu, L., Cheng, L., Hu, Q., Liu, Y., Hu, Z., Chen, D., & Cheng, L. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.03.027 · Cited by 73 · see citing works
Zhang, L., Tian, B., Li, Y., Tian, L., Meng, J., Yang, L., Zhang, Y., Chen, F., Zhang, H., Xu, H., et al. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b06488 · Cited by 69 · see citing works
Yuan, M., Qiu, Y., Zhang, L., Gao, H., & He, Q. (2015) · Drug Delivery · doi:10.3109/10717544.2015.1040527 · Cited by 67 · see citing works
MacEwan, S. R., & Chilkoti, A. (2012) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1197 · Cited by 63 · see citing works
Zheng, C.-Y., Ma, C., Bai, E., Yang, K., & Xu, R. (2015) · PubMed Central · Cited by 60 · see citing works
He, Y., Zhang, W., Xiao, Q., Fan, L., Huang, D., Chen, W., & He, W. (2022) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2022.11.002 · Cited by 53 · see citing works
Shadmani, N., Makvandi, P., Parsa, M., Azadi, A., Nedaei, K., Mozafari, N., Poursina, N., Mattoli, V., Tay, F. R., Maleki, A., et al. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00755 · Cited by 48 · see citing works
Advances in functional lipid nanoparticles: from drug delivery platforms to clinical applications
Dhayalan, M., Wang, W., Riyaz, S. U. M., Dinesh, R. A., Shanmugam, J., Irudayaraj, S. S., Stalin, A., Giri, J. P., Mallik, S., & Hu, R. (2024) · 3 Biotech · doi:10.1007/s13205-023-03901-8 · Cited by 50 · see citing works
Mei, L., Zhang, Q., Yang, Y., He, Q., & Gao, H. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.08.020 · Cited by 44 · see citing works
Hu, W. S., Cheng, L., Cheng, L., Zheng, M., Lei, Q., Hu, Z., Xu, M. X., Qiu, L., & Chen, D. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.09.024 · Cited by 43 · see citing works
Bandekar, A., Zhu, C., Gomez, A., Menzenski, M. Z., Sempkowski, M., & Sofou, S. (2012) · Molecular Pharmaceutics · doi:10.1021/mp3002717 · Cited by 43 · see citing works
CRISPR/Cas9 Delivery Potentials in Alzheimer’s Disease Management: A Mini Review
Hanafy, A. S., Schoch, S., & Lamprecht, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090801 · Cited by 41 · see citing works
Taming Cell Penetrating Peptides: Never Too Old To Teach Old Dogs New Tricks
Zhang, Q., Gao, H., & He, Q. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00428 · Cited by 40 · see citing works
Kuai, R., Subramanian, C., White, P. T., Timmermann, B. N., Moon, J. J., Cohen, M. S., & Schwendeman, A. A. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s140591 · Cited by 39 · see citing works
Jeong, C., Yoo, J., Lee, D., & Kim, Y. (2016) · Biomaterials Research · doi:10.1186/s40824-016-0076-0 · Cited by 38 · see citing works
Research Advances of Lipid Nanoparticles in the Treatment of Colorectal Cancer
Zhang, J., Ali, K., & Wang, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s466490 · Cited by 38 · see citing works
Therapeutic delivery using cell-penetrating peptides
Sawant, R. R., Patel, N. R., & Torchilin, V. P. (2013) · European Journal of Nanomedicine · doi:10.1515/ejnm-2013-0005 · Cited by 36 · see citing works
Zhu, Y., Wang, X., Zhang, J., Meng, F., Deng, C., Cheng, R., Feijén, J., & Zhong, Z. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.02.002 · Cited by 34 · see citing works
Zhang, J., Zheng, Y., Xie, X., Wang, L., Su, Z., Wang, Y., Leong, K. W., & Chen, M. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00404 · Cited by 32 · see citing works
Feng, L., Yan, S., Zhu, Q., Chen, J., Deng, L., Zheng, Y., Xue, W., & Guo, R. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00748a · Cited by 32 · see citing works
Surface Modification of Nonviral Nanocarriers for Enhanced Gene Delivery
Fortier, C., Durocher, Y., & Crescenzo, G. D. (2013) · Nanomedicine · doi:10.2217/nnm.13.194 · Cited by 31 · see citing works
Interactions of serum with polyelectrolyte-stabilized liposomes: Cryo-TEM studies
Wytrwał-Sarna, M., Bednář, J., Nowakowska, M., Wydro, P., & Kępczyński, M. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.02.040 · Cited by 30 · see citing works
Wang, Q., Gao, Z., Liu, S., Fan, B., Kang, L., Huang, W., & Jin, M. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.117 · Cited by 28 · see citing works
Tang, J., Fu, H., Kuang, Q., Zhang, L., Zhang, Q., Liu, Y., Ran, R., Gao, H., Zhang, Z., & He, Q. (2014) · Journal of drug targeting · doi:10.3109/1061186x.2013.875029 · Cited by 26 · see citing works
Silicone-stabilized liposomes as a possible novel nanostructural drug carrier
Lewandowska-Łańcucka, J., Mystek, K., Gilarska, A., Kamiński, K., Romek, M., Sulikowski, B., & Nowakowska, M. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.03.057 · Cited by 25 · see citing works
Tang, J., Zhang, L., Fu, H., Kuang, Q., Gao, H., Zhang, Z., & He, Q. (2014) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2013.12.004 · Cited by 25 · see citing works
Novel serum-tolerant lipoplexes target the folate receptor efficiently
Gorle, S., Ariatti, M., & Singh, M. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.04.012 · Cited by 24 · see citing works
Liu, Y., Lu, Z., Mei, L., Yu, Q., Tai, X., Wang, Y., Shi, K., Zhang, Z., & He, Q. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b12611 · Cited by 22 · see citing works
Polymeric nanocarriers for therapeutic gene delivery
Zhang, J., Yang, X., Chang, Z., Zhu, W., Ma, Y., & He, H. (2025) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2025.101015 · Cited by 20 · see citing works
Waggoner, L. E., Madias, M. I., Hurtado, A. A., & Kwon, E. J. (2021) · The AAPS Journal · doi:10.1208/s12248-021-00626-5 · Cited by 21 · see citing works
Hybrid Protein–Synthetic Polymer Nanoparticles for Drug Delivery
Koseva, N. S., Rydz, J., Stoyanova, E., & Mitova, V. A. (2015) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2014.12.003 · Cited by 18 · see citing works
Nanocarriers Conjugated with Cell Penetrating Peptides: New Trojan Horses by Modern Ulysses
Zappavigna, S., Misso, G., Falanga, A., Perillo, E., Novellino, E., Galdiero, M., Grieco, P., Caraglia, M., & Galdiero, S. (2016) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201017666160415155145 · Cited by 17 · see citing works
PEGylation and Cell-Penetrating Peptides: Glimpse into the Past and Prospects in the Future
Kumar, S., Singh, D., Kumari, P., Malik, R. S., Poonam, P., Parang, K., & Tiwari, R. K. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200128142603 · Cited by 17 · see citing works
Kao, H.-W., Chan, C.-J., Chang, Y., Hsu, Y., Lu, M., Wang, J. S.-J., Lin, Y.-Y., Wang, S.-J., & Wang, H. (2013) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2013.05.011 · Cited by 14 · see citing works
Optimization of Non-Viral Gene Therapeutics Using Bilamellar Invaginated Vesicles
Templeton, N. S. (2011) · Journal of Genetic Syndromes & Gene Therapy · doi:10.4172/2157-7412.s5-002 · Cited by 14 · see citing works
Multicompartment colloid systems with lipid and polymer membranes for biomedical applications
Koroleva, M. Y. (2023) · Physical Chemistry Chemical Physics · doi:10.1039/d3cp01984e · Cited by 13 · see citing works
Cao, Z., Zhu, J., Chen, X., Chen, Z., Wang, W., Zhou, Y., Hua, Y., Shi, J., & Chen, J. (2024) · Journal of Thoracic Disease · doi:10.21037/jtd-24-1078 · Cited by 15 · see citing works
["PEG dilemma" for liposomes and its solving approaches].
Zhang, D., Xu, H., Hu, M., & Deng, Y. (2015) · PubMed · Cited by 10 · see citing works
Natural and Synthetic Biopolymers in Drug Delivery and Tissue Engineering
Schneible, J. D., Daniele, M. A.-A., & Menegatti, S. (2020) · Wiley eBooks · doi:10.1002/9783527818310.ch9 · Cited by 10 · see citing works
Taheri, E., & Raeeszadeh‐Sarmazdeh, M. (2025) · Oncotarget · doi:10.18632/oncotarget.28691 · Cited by 9 · see citing works
Role and application of CRISPR-Cas9 in the management of Alzheimer’s disease
Soni, N., Kar, I., Narendrasinh, J. D., Shah, S. K., Konathala, L., Mohamed, N., Kachhadia, M. P., Chaudhary, M. H., Dave, V. A., Kumar, L., et al. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000001692 · Cited by 9 · see citing works
Biomaterial-based vascularization strategies for enhanced treatment of peripheral arterial disease
Wang, H., Lin, F., Zhang, Y., Lin, Y., Gao, B., & Kang, D. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03140-4 · Cited by 7 · see citing works
Abdelmessih, R. G., Xu, J., Hung, F. R., & Auguste, D. T. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00348 · Cited by 6 · see citing works
Tang, Y., Lu, S., Liang, W., He, Y., Hao, J., Xu, W., Sun, Y., & Zhan, C. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114465 · Cited by 5 · see citing works
Zheng, W., Li, Y., Du, J., & Yin, Z. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23924 · Cited by 5 · see citing works
Mitochondrial Targeting Probes, Drug Conjugates, and Gene Therapeutics
Cerrato, C. P., Kivijärvi, T., & Langel, Ü. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1752-6_27 · Cited by 4 · see citing works
Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery
Templeton, N. S., & Senzer, N. N. (2012) · Journal of Drug Delivery · doi:10.1155/2012/173465 · Cited by 4 · see citing works
Optimization of Non-Viral Gene Therapeutics Using Bilamellar Invaginated
Templeton, V., & Senzer, N. N. (2011)
Pacifastin-derived Peptides Target Tumors for Use in In Vivo Imaging
Sottero, T. L., Girard, E. J., Myers, C. H., Hopping, G., Mhyre, A. J., & Olson, J. M. (2018) · Anticancer Research · doi:10.21873/anticanres.12191
Shi, H., Xu, Q., Li, F., Fan, C., & Han, Y. (2026) · Molecules · doi:10.3390/molecules31091409
- Authors
- Kuai, R., Yuan, W., Li, W., Qin, Y., Tang, J., Yuan, M., Fu, L., Ran, R., Zhang, Z., & He, Q.
- Affiliations
- Sichuan University (CN)
- Chongqing Medical University (CN)
- Corresponding author
- He, Qin
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-10-26
- Volume
- 8
- Issue
- 6
- Pages
- 2151-2161
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W2331711315
- Cited by
- 76
- References
- 43
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 3 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 10 · 2014: 14 · 2013: 7 · 2012: 6
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- cell-penetrating peptides, TAT peptide, liposomal drug delivery, solid tumor targeting, systemic administration, tumor accumulation, PEGylated liposomes, PEGylation, liver distribution, tumor-targeted delivery
- MeSH terms
- Animals, Antineoplastic Agents, Disease Models, Animal, Drug Carriers, Drug Stability, Fluorescent Dyes, Injections, Intravenous, Liposomes, Male, Mice, Inbred BALB C, Neoplasms, Polyethylene Glycols, Molecular Structure, Gene Products, tat, Drug Delivery Systems, Cell Line, Tumor, Mice, Cell-Penetrating Peptides
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