Diffusion of Macromolecules in the Brain: Implications for Drug Delivery

Wolak, Daniel J., Thorne, Robert G.·2013·Molecular Pharmaceutics

DOI 10.1021/mp300495e

Cited by (299)

Items 101–200 of 299

Fast Estimation of the Blood–Brain Barrier Permeability by Pulling a Ligand through a Lipid Membrane
Nguyen Quoc Thai, Panagiotis E. Theodorakis, Mai Suan Li · 2020 · Journal of Chemical Information and Modeling
Recent Advancements and Strategies for Overcoming the Blood–Brain Barrier Using Albumin-Based Drug Delivery Systems to Treat Brain Cancer, with a Focus on Glioblastoma
Camelia-Elena Tincu, Călin Vasile Andrițoiu, Marcel Popa, Lăcrămioara Ochiuz · 2023 · Polymers
Measurement of Free Drug Concentration from Biological Tissue by Solid-Phase Microextraction: In Silico and Experimental Study
Mohammad Huq, Marcos Tascón, Emir Nazdrajić, Anna Roszkowska, Janusz B. Pawliszyn · 2019 · Analytical Chemistry
Predicting the Blood-Brain Barrier Permeability of New Drug-Like Compounds via HPLC with Various Stationary Phases
Małgorzata Janicka, Małgorzata Sztanke, Krzysztof Sztanke · 2020 · Molecules
Transport Mechanisms of Squalenoyl-Adenosine Nanoparticles Across the Blood–Brain Barrier
Alice Gaudin, Oya Tagit, Dunja Sobot, Sinda Lepêtre‐Mouelhi, Julie Mougin, Thomas Martens, Kevin Braeckmans, Valérie Nicolas, Didier Desmaële, Stefaan C. De Smedt et al. · 2015 · Chemistry of Materials
Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site
Paula Muresan, Phoebe McCrorie, Fiona N.C. Smith, Catherine E. Vasey, Vincenzo Taresco, David J. Scurr, Stefanie Kern, Stuart James Smith, Pavel Gershkovich, Ruman Rahman et al. · 2022 · European Journal of Pharmaceutics and Biopharmaceutics
Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles
Tuomas Olavi Lilius, Kristian Nygaard Mortensen, Claire Deville, Terhi Johanna Lohela, Frederik Filip Stæger, Björn Sigurðsson, Elisabetta Maria Fiordaliso, Marko Rosenholm, Chris Kamphuis, Freek J. Beekman et al. · 2023 · Journal of Controlled Release
Magnetic Resonance Imaging and Modeling of the Glymphatic System
Jasleen Kaur, Esmaeil Davoodi‐Bojd, Lara M. Fahmy, Li Zhang, Guangliang Ding, Jiani Hu, Zhenggang Zhang, Michael Chopp, Quan Jiang · 2020 · Diagnostics
Defining novel functions for cerebrospinal fluid in ALS pathophysiology
Koy Chong Ng Kee Kwong, Arpan R. Mehta, Maiken Nedergaard, Siddharthan Chandran · 2020 · Acta Neuropathologica Communications
Pulsed ultrasound expands the extracellular and perivascular spaces of the brain
David S. Hersh, Ben Nguyen, Jimena G. Dancy, Arjun Rohit Adapa, Jeffrey A. Winkles, Graeme F. Woodworth, Anthony J. Kim, Victor Frenkel · 2016 · Brain Research
Current Strategies for the Delivery of Therapeutic Proteins and Enzymes to Treat Brain Disorders
Jason Thomas Duskey, Daniela Belletti, Francesca Pederzoli, Maria Angela Vandelli, Flavio Forni, Barbara Ruozi, Giovanni Tosi · 2017 · International review of neurobiology
Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins
Jeanette M. Metzger, Yuyuan Wang, Samuel S. Neuman, Kathy J. Snow, Stephen A. Murray, Cathleen M. Lutz, Viktoriya Bondarenko, Jesi Felton, Kirstan Gimse, Ruosen Xie et al. · 2022 · Biomaterials
Brain extracellular space: geometry, matrix and physiological importance.
Padideh Kamali‐Zare, Charles Nicholson · 2013 · Europe PMC (PubMed Central)
Application of ionic liquid to enhance the nose-to-brain delivery of etodolac
Hiroaki Tanigawa, Naoto Suzuki, Toyofumi Suzuki · 2022 · European Journal of Pharmaceutical Sciences
Systems‐level thinking for nanoparticle‐mediated therapeutic delivery to neurological diseases
Chad Curtis, Mengying Zhang, Rick Liao, Thomas Ragnar Wood, Elizabeth A. Nance · 2016 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
MR-guided transcranial focused ultrasound safely enhances interstitial dispersion of large polymeric nanoparticles in the living brain
David S. Hersh, Pavlos Anastasiadis, Ali Mohammadabadi, Ben Nguyen, Sijia Guo, Jeffrey A. Winkles, Anthony J. Kim, Rao P. Gullapalli, Asaf Keller, Victor Frenkel et al. · 2018 · PLoS ONE
A quantum biochemistry investigation of willardiine partial agonism in AMPA receptors
José Xavier Neto, Umberto Laino Fulco, E.L. Albuquerque, Gilberto Corso, Eveline Matias BEZERRA, E. W. S. Caetano, Roner Ferreira da COSTA, V. N. Freire · 2015 · Physical Chemistry Chemical Physics
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration
Marvin Reich, Matthew J. Simon, Beate Polke, Iñaki Paris, Georg Werner, Christian M. Schrader, Lena Spieth, Sonnet S. Davis, Sophie Robinson, Gabrielly Lunkes de Melo et al. · 2024 · Science Translational Medicine
Nanobodies as Versatile Tool for Multiscale Imaging Modalities
Marco Erreni, Tilo Schorn, Francesca D’Autilia, Andrea Doni · 2020 · Biomolecules
Neuropathological changes and amyloid-related imaging abnormalities in Alzheimer's disease treated with aducanumab versus untreated: a retrospective case–control study
Baayla D.C. Boon, Yoav D. Piura, Christina M. Moloney, Jessica L Chalk, Sarah Lincoln, Matthew H. Rutledge, Darren M. Rothberg, Naomi Kouri, Kelly M. Hinkle, Shanu Faerch Roemer et al. · 2025 · The Lancet Neurology
Strategies to enhance the distribution of nanotherapeutics in the brain
Clark Zhang, Panagiotis Mastorakos, Miguel C. Sobral, Sneha Berry, Eric Song, Elizabeth A. Nance, Charles G. Eberhart, Justin S. Hanes, Jung Soo Suk · 2017 · Journal of Controlled Release
Identification of variable lymphocyte receptors that can target therapeutics to pathologically exposed brain extracellular matrix
Benjamin J. Umlauf, Paul A. Clark, Jason M. Lajoie, Julia V. Georgieva, Samantha B. Bremner, Brantley R. Herrin, John S. Kuo, Eric V. Shusta · 2019 · Science Advances
Gut Microbiome: A New Organ System in Body
Haseeb Anwar, Shahzad Irfan, Ghulam Hussain, Muhammad Naeem Faisal, Humaira Muzaffar, Imtiaz Mustafa, Imran Mukhtar, Saima Malik, Muhammad Irfan Ullah · 2019 · IntechOpen eBooks
Predicting in situ nanoparticle behavior using multiple particle tracking and artificial neural networks
Chad Curtis, Mike McKenna, Ceza Pontes, Dorsa Toghani, Alex Choe, Elizabeth A. Nance · 2019 · Nanoscale
Intrathecal delivery of Macromolecules: Clinical status and emerging technologies
Rana Ajeeb, John R. Clegg · 2023 · Advanced Drug Delivery Reviews
Quantitative analysis of inulin distribution in the brain focused on nose-to-brain route via olfactory epithelium by reverse esophageal cannulation
Mitsuyoshi Fukuda, Takanori Kanazawa, Shingo Iioka, Takayuki Oguma, Ryohei Iwasa, Saki Masuoka, Naoto Suzuki, Yasuhiro Kosuge, Toyofumi Suzuki · 2021 · Journal of Controlled Release
Current status and advances to improving drug delivery in diffuse intrinsic pontine glioma
Lauren Arms, Ryan J. Duchatel, Evangeline R. Jackson, Pedro Garcia Sobrinho, Matthew D. Dun, Susan Hua · 2024 · Journal of Controlled Release
Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model
Michael E. Barish, Kelsey A. Herrmann, Yang Tang, Siranush Herculian, Marianne Z. Metz, Soraya Aramburo, Revathiswari Tirughana, Margarita Gutova, Alexander J. Annala, Rex A. Moats et al. · 2017 · Stem Cells Translational Medicine
Deep Tissue Translocation of Graphene Oxide Sheets in Human Glioblastoma 3D Spheroids and an Orthotopic Xenograft Model
Irene de Lázaro, Paul Sharp, Cansu Gürcan, Ahmet Ceylan, Maria Stylianou, Thomas Kisby, Yingxian Chen, Sandra Vranic, Katharine Barr, Hadiseh Taheri et al. · 2020 · Advanced Therapeutics
Choroid Plexus and Drug Removal Mechanisms
Austin Sun, Joanne Wang · 2021 · The AAPS Journal
Real-time Iontophoresis with Tetramethylammonium to Quantify Volume Fraction and Tortuosity of Brain Extracellular Space
John Odackal, Robert Colbourn, Namrita Jain Odackal, Lian Tao, Charles Nicholson, Sabina Hrabětová · 2017 · Journal of Visualized Experiments
Shear-Induced Amyloid Formation in the Brain: I. Potential Vascular and Parenchymal Processes
Trumbore, Conrad N. · 2016 · Journal of Alzheimer's Disease
Intranasal delivery of hGDNF plasmid DNA nanoparticles results in long-term and widespread transfection of perivascular cells in rat brain
Amirah E.-E. Aly, Brendan Harmon, Linas Padegimas, Ozge Sesenoglu‐Laird, Mark J. Cooper, David M. Yurek, Barbara L. Waszczak · 2018 · Nanomedicine Nanotechnology Biology and Medicine
Envisioning the future of polymer therapeutics for brain disorders
Fernanda Rodriguez‐Otormin, Aroa Duro‐Castaño, Inmaculada Conejos‐Sánchez, Maria Jesus Vicent · 2018 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
Anatomy and Physiology of the Blood–Brain Barriers
N. Joan Abbott · 2013 · AAPS advances in the pharmaceutical sciences series
Focal, remote-controlled, chronic chemical modulation of brain microstructures
Khalil B. Ramadi, Canan Dağdeviren, Kevin C. Spencer, Pauline Joe, Max J. Cotler, Erin B. Rousseau, Carlos Nunez-Lopez, Ann M. Graybiel, Róbert Langer, Michael J. Cima · 2018 · Proceedings of the National Academy of Sciences
ECS Dynamism and Its Influence on Neuronal Excitability and Seizures
Robert Colbourn, Aditi A. Naik, Sabina Hrabětová · 2019 · Neurochemical Research
Targeting the Choroid Plexuses for Protein Drug Delivery
Mark A. Bryniarski, Tianjing Ren, Abbas R. Rizvi, Anthony M. Snyder, Marilyn E. Morris · 2020 · Pharmaceutics
Pharmaceutical Salts: Comprehensive Insights From Fundamental Chemistry to FDA Approvals (2019–2023)
Dhaval Mori, Kiran Rameshbhai Dudhat, Aastha Gadoya, Sunny R. Shah, Trupesh M. Pethani, Nilesh Jambukiya, Ajay M. Patel, Chintan Kalsariya, Jainabparvin Ansari, Chetan H. Borkhataria · 2025 · AAPS PharmSciTech
Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: A systematic review and meta-analysis
Shane Vincent Hegarty, David J. Lee, Gerard W. O’Keeffe, Aideen M. Sullivan · 2017 · Parkinsonism & Related Disorders
MRI Guided Focused Ultrasound-Mediated Delivery of Therapeutic Cells to the Brain: A Review of the State-of-the-Art Methodology and Future Applications
Nabid Ahmed, Dheeraj Gandhi, Elias R. Melhem, Victor Frenkel · 2021 · Frontiers in Neurology
Transport in the Brain Extracellular Space: Diffusion, but Which Kind?
Eugene B. Postnikov, Anastasia I. Lavrova, Dmitry Engelevich Postnov · 2022 · International Journal of Molecular Sciences
Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice
Xiao J. Tong, Gökhan Akdemir, Meetu Wadhwa, Alan S. Verkman, Alex J. Smith · 2024 · Fluids and Barriers of the CNS
Noradrenergic influences in the basolateral amygdala on inhibitory avoidance memory are mediated by an action on α2-adrenoceptors
Barbara Ferry, Sandrine Parrot, Marc R. Marien, Christine Lazarus, Jean‐Christophe Cassel, James Lafayette McGaugh · 2014 · Psychoneuroendocrinology
Advances in the use of chitosan and chlorotoxin- functionalized chitosan polymers in drug delivery and detection of glioma – A review
Marzenna Wiranowska · 2024 · Carbohydrate Polymer Technologies and Applications
Modulation of solute diffusivity in brain tissue as a novel mechanism of transcranial direct current stimulation (tDCS)
Yifan Xia, Wasem Khalid, Zhaokai Yin, Guangyao Huang, Marom Bikson, Bingmei M. Fu · 2020 · Scientific Reports
Advanced nanoparticle engineering for precision therapeutics of brain diseases
Muhammad Ismail, Jiayi Liu, Ningyang Wang, Dongya Zhang, Changjiang Qin, Bingyang Shi, Meng Zheng · 2025 · Biomaterials
The Mechanism of Downregulated Interstitial Fluid Drainage Following Neuronal Excitation
Yuanyuan Li, Hongbin Han, Kuangyu Shi, Dehua Cui, Jun Yang, Ian Alberts, Lan Yuan, Guomei Zhao, Rui Wang, Xianjie Cai et al. · 2020 · Aging and Disease
Brain Distribution of Drugs: Pharmacokinetic Considerations
Irena Loryan, Margareta Hammarlund‐Udenaes, Stina Syvänen · 2020 · Handbook of experimental pharmacology
More than a drainage fluid: the role of CSF in signaling in the brain and other effects on brain tissue
Sebastian Illes · 2017 · Handbook of clinical neurology
Effect of Cerebrospinal Fluid Circulation on Nose-to-Brain Direct Delivery and Distribution of Caffeine in Rats
Daisuke Inoue, Tomoyuki Furubayashi, Akiko Tanaka, Toshiyasu Sakane, Kiyohiko Sugano · 2020 · Molecular Pharmaceutics
Convection-enhanced delivery for brain malignancies: Technical parameters, formulation strategies and clinical perspectives
Sara Jamshidi Parvar, Cheng In Wong, Andrew Lewis, Elwira Szychot, Christopher J. Morris, David Shorthouse, Karolina Dziemidowicz · 2025 · Advanced Drug Delivery Reviews
Distribution and Diffusion of Macromolecule Delivery to the Brain via Focused Ultrasound using Magnetic Resonance and Multispectral Fluorescence Imaging
Michael Valdez, E. Fernández, T. Matsunaga, R. Erickson, T. Trouard · 2019 · Ultrasound in Medicine and Biology
Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease
Mallory J. Stenslik, Lisa F. Potts, James Sonne, Wayne A. Cass, Jadwiga T. Turchan-Cholewo, François Pomerleau, Peter F. Huettl, Yi Ai, Don Marshall Gash, Greg A. Gerhardt et al. · 2015 · Journal of Neuroscience Methods
Strategies for enhanced gene delivery to the central nervous system
Zhenghong Gao · 2024 · Nanoscale Advances
Targeting Transferrin Receptor to Transport Antisense Oligonucleotides Across the Blood-Brain Barrier
Scarlett J. Barker, Mai B. Thayer, Chaeyoung Kim, David Tatarakis, Matthew J. Simon, Rebekah L. Dial, Lizanne Nilewski, Robert C. Wells, Yinhan Zhou, Megan E. Afetian et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Microglial phagocytosis dysfunction in the dentate gyrus is related to local neuronal activity in a genetic model of epilepsy
Virginia Sierra‐Torre, Ainhoa Plaza‐Zabala, Paolo Bonifazi, Oihane Abiega, Irune Díaz‐Aparicio, Saara Tegelberg, Anna‐Elina Lehesjoki, Jorge Valero, Amanda Sierra · 2020 · Epilepsia
Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury
Jiaying Shi, Jiajia Tang, Xu Jin, Ning Jiang, Yuanwei Yang, Honglin Chen, Yuhan Han, Xianhua Fu · 2025 · Frontiers in Bioengineering and Biotechnology
Design, synthesis, and evaluation of cisplatin-containing EGFR targeting bioconjugates as potential therapeutic agents for brain tumors
Rolf F. Barth, Gong Jhe Wu, Walter Hans Meisen, Robin J. Nakkula, Weilian Yang, Tianyao Huo, David A. Kellough, Pravin T. P. Kaumaya, Lawrence M Agius, Balveen Kaur et al. · 2016 · OncoTargets and Therapy
Effect of extradural constriction on CSF flow in rat spinal cord
Joel A. Berliner, Thomas Woodcock, Elmira Najafi, Sarah J. Hemley, Magdalena A. Lam, Shaokoon Cheng, Lynne E. Bilston, Marcus Andrew Stoodley · 2019 · Fluids and Barriers of the CNS
A novel strategy for delivering N iemann‐ P ick type C2 proteins across the blood–brain barrier using the brain endothelial‐specific AAV‐BR1 virus
Charlotte Laurfelt Munch Rasmussen, Eva Hede, Lisa Greve Routhe, Jakob Körbelin, Steinunn Sara Helgudóttir, Louiza Bohn Thomsen, Markus Schwaninger, Annette Burkhart, Torben Moos · 2022 · Journal of Neurochemistry
Titer and Product Affect the Distribution of Gene Expression after Intraputaminal Convection-Enhanced Delivery
Marina Elena Emborg, Samuel A. Hurley, Valerie L. Joers, Do Tromp, Christine R. Swanson, Sachiko Ohshima-Hosoyama, Viktorya Bondarenko, Kyle Cummisford, Marc A. F. Sonnemans, Stephan Hermening et al. · 2014 · Stereotactic and Functional Neurosurgery
Controversies and Misconceptions Related to Cerebrospinal Fluid Circulation: A Review of the Literature from the Historical Pioneers’ Theories to Current Models
Giorgio Mantovani, Marta Menegatti, Alba Scerrati, Michele Alessandro Cavallo, Pasquale DE BONIS · 2018 · BioMed Research International
Nanotherapeutics and the Brain
Andrea Joseph, Elizabeth A. Nance · 2022 · Annual Review of Chemical and Biomolecular Engineering
Focused ultrasound enhances transgene expression of intranasal hGDNF DNA nanoparticles in the sonicated brain regions
Amirah E.-E. Aly, Tao Sun, Yongzhi Zhang, Zejun Li, Margee J. Kyada, Qingxi Ma, Linas Padegimas, Ozge Sesenoglu‐Laird, Mark J. Cooper, Nathan Judson McDannold et al. · 2023 · Journal of Controlled Release
Brain-Penetrating Peptide Shuttles across the Blood–Brain Barrier and Extracellular-like Space
Xiujuan Peng, Xinquan Liu, Jae You Kim, Alex Nguyen, Jasmim Leal, Debadyuti Ghosh · 2023 · Bioconjugate Chemistry
Voxelized Model of Brain Infusion That Accounts for Small Feature Fissures: Comparison With Magnetic Resonance Tracer Studies
Wei Dai, Garrett W. Astary, Aditya K. Kasinadhuni, Paul Richard Carney, Thomas H. Mareci, Malisa Sarntinoranont · 2016 · Journal of Biomechanical Engineering
Drug penetration in pediatric brain tumors: Challenges and opportunities
Jenny P. Patel, Susan E. Spiller, Elizabeth D. Barker · 2021 · Pediatric Blood & Cancer
Anomalous Diffusion Inspires Anatomical Insights
Charles Nicholson · 2015 · Biophysical Journal
Crossing the blood–brain barrier: nanoparticle-based strategies for neurodegenerative disease therapy
Elena Haro-Martínez, Elena Muscolino, Núria Moral, Jordi Durán, Cristina Fornaguera · 2025 · Drug Delivery and Translational Research
Blood-brain barrier co-culture models to study nanoparticle penetration: focus on co-culture systems
Szilvia Veszelka, Alexandra Bocsik, Fruzsina R. Walter, Dóra Hantosi, Mária A. Deli · 2015 · Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)
Improving the Prediction of Local Drug Distribution Profiles in the Brain with a New 2D Mathematical Model
Esmée Vendel, Vivi Rottschäfer, Elizabeth C. M. de Lange · 2018 · Bulletin of Mathematical Biology
Spatiotemporal presentation of exogenous SDF-1 with PLGA nanoparticles modulates SDF-1/CXCR4 signaling axis in the rodent cortex
Dipankar Dutta, Kassondra N. Hickey, Mariama Salifu, C. Fauer, Crystal Willingham, Sarah E. Stabenfeldt · 2017 · Biomaterials Science
Shear-Induced Amyloid Formation in the Brain: III. The Roles of Shear Energy and Seeding in a Proposed Shear Model
Conrad N. Trumbore · 2018 · Journal of Alzheimer s Disease
Is solute movement within the extracellular spaces of brain gray matter brought about primarily by diffusion or flow? A commentary on “Analysis of convective and diffusive transport in the brain interstitium” Fluids and Barriers of the CNS (2019) 16:6 by L. Ray, J.J. Iliff and J.J. Heys
Stephen B. Hladky, Margery A. Barrand · 2019 · Fluids and Barriers of the CNS
The Extracellular and Perivascular Spaces of the Brain
Pizzo, Michelle E., Thorne, Robert G. · 2017 · Brain Edema
Communications Among Neurocytes in Parkinson's Disease Regulated by Differential Metabolism and Blood‐Brain Barrier Traversing of Chiral Gold Cluster‐MOF Integrated Nanoparticles
Junyang Chen, Gaoxiang Xu, Runpu Shen, Jianzhong Xu, Congcong Lu, Xin Li, Qi Feng, Qing Li · 2025 · Advanced Science
Effect of the Size of Protein Therapeutics on Brain Pharmacokinetics Following Systematic Administration
Hsueh-Yuan Chang, Shengjia Wu, Yingyi Li, Leiming Guo, Yuelin Li, Dhaval K. Shah · 2022 · The AAPS Journal
The secret world in the gaps between brain cells
Charles Nicholson · 2022 · Physics Today
Bridging the blood-brain barrier: strategies to improve delivery of biologics to tumors in the brain
Gautham Gampa, Rahul Vadlakonda, Eric Gary Stefanich, Amrita V. Kamath, Shraddha Sadekar, Vittal Shivva · 2026 · Fluids and Barriers of the CNS
Brain Distribution of Drugs: Brain Morphology, Delivery Routes, and Species Differences
Fanchon Bourasset, Sylvain Auvity, Robert G. Thorne, Jean‐Michel Scherrmann · 2020 · Handbook of experimental pharmacology
Investigation of Antibody Pharmacokinetics in the Brain Following Intra-CNS Administration and Development of PBPK Model to Characterize the Data
Shengjia Wu, Hsueh-Yuan Chang, Ekram Ahmed Chowdhury, Hsien Wei Huang, Dhaval K. Shah · 2024 · The AAPS Journal
An AAV variant selected through NHP screens robustly transduces the brain and drives secreted protein expression in NHPs and mice
Luis Tecedor, Yong Hong Chen, David E. Leib, Paul T. Ranum, Megan S. Keiser, Brian C. Lewandowski, Ellie M. Carrell, Елена Лысенко, Icnelia Huerta-Ocampo, Sakshi Arora et al. · 2025 · Science Translational Medicine
A review of flux considerations for in vivo neurochemical measurements
David W. Paul, Julie A. Stenken · 2015 · The Analyst
Miniaturized neural implants for localized and controllable drug delivery in the brain
Xiaotong Zhao, Maosen Deng, Jun Wang, Bin Liu, Yuan Dong, Zhe Li · 2023 · Journal of Materials Chemistry B
Methodology and effects of repeated intranasal delivery of DNSP-11 in awake Rhesus macaques
Mallory J. Stenslik, April Evans, François Pomerleau, Ryan M. Weeks, Peter F. Huettl, E. Foreman, Jadwiga T. Turchan-Cholewo, Anders H. Andersen, Wayne A. Cass, Z. Zhang et al. · 2018 · Journal of Neuroscience Methods
Cell and Gene Therapies for Mucopolysaccharidoses: Base Editing and Therapeutic Delivery to the CNS
Chloe L. Christensen, Rhea E. Ashmead, Francis Y.M. Choy · 2019 · Diseases
Shear-induced amyloid formation of IDPs in the brain
Conrad N. Trumbore · 2019 · Progress in molecular biology and translational science
Spatially Resolved Analytical Chemistry in Intact, Living Tissues
Maura C. Belanger, Parastoo Anbaei, Austin F. Dunn, Andrew W.L. Kinman, Rebecca R. Pompano · 2020 · Analytical Chemistry
Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer’s Disease
Jana Turečková, Monika Kamenická, Denisa Koleničová, Tereza Filipi, Zuzana Heřmanová, Ján Kriška, Lenka Mészárošová, Barbora Pukajova, Lukáš Valihrach, Peter Androvic et al. · 2022 · Frontiers in Aging Neuroscience
Fn14-Directed DART Nanoparticles Selectively Target Neoplastic Cells in Preclinical Models of Triple-Negative Breast Cancer Brain Metastasis
Christine P. Carney, Anshika Kapur, Pavlos Anastasiadis, Rodney M. Ritzel, Chixiang Chen, Graeme F. Woodworth, Jeffrey A. Winkles, Anthony J. Kim · 2022 · Molecular Pharmaceutics
Fast uncertainty quantification of tracer distribution in the brain interstitial fluid with multilevel and quasi Monte Carlo
Matteo Croci, Vegard Vinje, Marie Elisabeth Rognes · 2020 · International Journal for Numerical Methods in Biomedical Engineering
Biodistribution Analysis of an Anti-EGFR Antibody in the Rat Brain: Validation of CSF Microcirculation as a Viable Pathway to Circumvent the Blood-Brain Barrier for Drug Delivery
Ghazal Naseri Kouzehgarani, Pankaj Kumar, Susan E. Bolin, Edward B. Reilly, Didier R. Lefebvre · 2022 · Pharmaceutics
Synergistic activity and molecular modelling of fosfomycin combinations with some antibiotics against multidrug resistant Helicobacter pylori
Ahmed Megahed Abouwarda, Tarek Ismaeil, Wael Mohamed Abu El-Wafa, Ahmed Hassan Ibrahim Faraag · 2022 · World Journal of Microbiology and Biotechnology
Polymer nanocarriers for targeted local delivery of agents in treating brain tumors
Alexander D. Josowitz, Ranjit S. Bindra, W. Mark Saltzman · 2022 · Nanotechnology
Multiscale co-simulation of deep brain stimulation with brain networks in neurodegenerative disorders
Hina Shaheen, Swadesh Pal, Roderick Melnik · 2022 · Brain Multiphysics
Combined Micellar Liquid Chromatography Technique and QSARs Modeling in Predicting the Blood–Brain Barrier Permeation of Heterocyclic Drug-like Compounds
Małgorzata Janicka, Anna Śliwińska, Małgorzata Sztanke, Krzysztof Sztanke · 2022 · International Journal of Molecular Sciences
Quantitative Measurement of Brain Extracellular Space with Three-Dimensional Electron Microscopy Imaging
Xinrui Huang, Kerui Li, Yiqun Liu, Chuqiao Yang, Hongbin Han · 2023 · Sensing and Imaging
Miniature Devices in the Wild: Modeling Molecular Communication in Complex Extracellular Spaces
Guopeng Wei, Radu Mărculescu · 2014 · IEEE Journal on Selected Areas in Communications
A Highly Translatable Dual‐arm Local Delivery Strategy To Achieve Widespread Therapeutic Coverage in Healthy and Tumor‐bearing Brain Tissues
Karina Negrón, Gijung Kwak, Heng Wang, Haolin Li, Yiting Huang, Shun-Wen Chen, Betty Tyler, Charles G. Eberhart, Justin S. Hanes, Jung Soo Suk · 2023 · Small