Bioavailability of curcumin: Problems and promises

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1. Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects
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2. The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases
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3. Improved Bioavailability of Poorly Water-Soluble Drug Curcumin in Cellulose Acetate Solid Dispersion
   Shuxin Wan, Yingqian Sun, Xiuxiang Qi, Fengping Tan · 2011 · AAPS PharmSciTech
4. Discovery of a new function of curcumin which enhances its anticancer therapeutic potency
   Koji Nagahama, Tomoya Utsumi, Takayuki Kumano, Saeko Maekawa, Naho Oyama, Junji Kawakami · 2016 · Scientific Reports
5. Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans
   Monika Sharma, Raman Manoharlal, Nidhi Puri, Rajendra Prasad · 2009 · Bioscience Reports
6. Neuronal Uptake and Neuroprotective Effect of Curcumin-Loaded PLGA Nanoparticles on the Human SK-N-SH Cell Line
   Sihem Doggui, Jasjeet Kaur Sahni, Madeleine Arseneault, Lê H. Dao, Charles Ramassamy · 2012 · Journal of Alzheimer s Disease
7. Terpene microemulsions for transdermal curcumin delivery: Effects of terpenes and cosurfactants
   Chi‐Hsien Liu, Fu-Yen Chang, De-Kai Hung · 2010 · Colloids and Surfaces B Biointerfaces
8. Cyclodextrin‐based nanosponges: a versatile platform for cancer nanotherapeutics development
   Shankar Swaminathan, Roberta Cavalli, Francesco Trotta · 2016 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
9. Modification of soy protein isolate by glutaminase for nanocomplexation with curcumin
   Huan Xiang, Dongxiao Sun‐Waterhouse, Chun Cui, Wei Wang, Keming Dong · 2018 · Food Chemistry
10. Curcumin: New Insights into an Ancient Ingredient against Cancer
    Ella Willenbacher, Shah Zeb Khan, Sara Cecilia Altuna, Dario Trapani, Sadaqat Hussain, Dominik Georg Friedrich Wolf, Wolfgang Willenbacher, Gilbert Spizzo, Andreas Seeber · 2019 · International Journal of Molecular Sciences
11. An in vitro study of liposomal curcumin: Stability, toxicity and biological activity in human lymphocytes and Epstein-Barr virus-transformed human B-cells
    Changguo Chen, Thomas D. Johnston, Hoonbae Jeon, Roberto Gedaly, Patrick P. McHugh, Thomas G. Burke, Dinesh Ranjan · 2008 · International Journal of Pharmaceutics
12. A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels
    Amirhossein Sahebkar · 2013 · Clinical Nutrition
13. Evaluation of curcumin loaded chitosan/PEG blended PLGA nanoparticles for effective treatment of pancreatic cancer
    Geetanjali Arya, Manasi Das, Sanjeeb Kumar Sahoo · 2018 · Biomedicine & Pharmacotherapy
14. Study on simultaneous binding of resveratrol and curcumin to β-lactoglobulin: Multi-spectroscopic, molecular docking and molecular dynamics simulation approaches
    Xiaoge Zhang, Yingcong Lu, Ru Song Zhao, Ce Wang, Cuina Wang, Tiehua Zhang · 2021 · Food Hydrocolloids
15. Hyaluronic Acid Engineered Nanomicelles Loaded with 3,4-Difluorobenzylidene Curcumin for Targeted Killing of CD44+ Stem-Like Pancreatic Cancer Cells
    Prashant Kesharwani, Sanjeev Banerjee, Subhash Padhyé, Fazlul H. Sarkar, Arun K. Iyer · 2015 · Biomacromolecules
16. Delivery by Design (DbD): A Standardized Approach to the Development of Efficacious Nanoparticle‐ and Microparticle‐Based Delivery Systems
    David Julian McClements · 2017 · Comprehensive Reviews in Food Science and Food Safety
17. Curcumin-laden exosomes target ischemic brain tissue and alleviate cerebral ischemia-reperfusion injury by inhibiting ROS-mediated mitochondrial apoptosis
    Ruyi He, Yibing Jiang, Yijie Shi, Jia Liang, Liang Zhao · 2020 · Materials Science and Engineering C
18. ROS generation mediates the anti-cancer effects of WZ35 via activating JNK and ER stress apoptotic pathways in gastric cancer
    Peng Zou, Junru Zhang, Yiqun Xia, Karvannan Kanchana, Guilong Guo, Wenbo Chen, Yi‐Wen Huang, Zhe Wang, Shulin Yang, Guang Liang · 2015 · Oncotarget
19. Optimised nano-formulation on the bioavailability of hydrophobic polyphenol, curcumin, in freely-moving rats
    Yin-Meng Tsai, Woan-Ching Jan, Chao-Feng Chien, Wen-Chuan Lee, Lie-Chwen Lin, Tung‐Hu Tsai · 2011 · Food Chemistry
20. Redox Balance in the Pathogenesis of Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities
    Roberto Gambino, Giovanni Musso, Maurizio Cassader · 2010 · Antioxidants and Redox Signaling
21. Curcumin-loaded solid lipid nanoparticles with Brij78 and TPGS improved in vivo oral bioavailability and in situ intestinal absorption of curcumin
    Hongyu Ji, Jingling Tang, Mengting Li, Jinmei Ren, Nannan Zheng, Linhua Wu · 2014 · Drug Delivery
22. Curcumin-Encapsulated MePEG/PCL Diblock Copolymeric Micelles: A Novel Controlled Delivery Vehicle for Cancer Therapy
    Chandana Mohanty, Sarbari Acharya, Anjan Kumar Mohanty, Fahima Dilnawaz, Sanjeeb Kumar Sahoo · 2010 · Nanomedicine
23. Fluorocurcumins as Cyclooxygenase-2 Inhibitor: Molecular Docking, Pharmacokinetics and Tissue Distribution in Mice
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24. Photoinitiating systems for cationic photopolymerization: Ongoing push toward long wavelengths and low light intensities
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25. Challenges and Opportunities of Deferoxamine Delivery for Treatment of Alzheimer’s Disease, Parkinson’s Disease, and Intracerebral Hemorrhage
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26. ApoE3 Mediated Poly(butyl) Cyanoacrylate Nanoparticles Containing Curcumin: Study of Enhanced Activity of Curcumin against Beta Amyloid Induced Cytotoxicity Using In Vitro Cell Culture Model
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27. The emerging role of redox-sensitive Nrf2–Keap1 pathway in diabetes
    Elango Bhakkiyalakshmi, Dornadula Sireesh, Palanisamy Rajaguru, Ramasamy Paulmurugan, Kunka Mohanram Ramkumar · 2014 · Pharmacological Research
28. Partial Correction of Cystic Fibrosis Defects with PLGA Nanoparticles Encapsulating Curcumin
    Malgorzata S. Cartiera, Elisa Carvalho Ferreira, Christina R. Caputo, Marie E. Egan, Michael J. Caplan, W. Mark Saltzman · 2009 · Molecular Pharmaceutics
29. Recent progress in doxorubicin-induced cardiotoxicity and protective potential of natural products
    Jie Zhong Yu, Changxi Wang, Qi Kong, Xiaxia Wu, Jin‐Jian Lu, Xiuping Chen · 2018 · Phytomedicine
30. Curcumin: pharmaceutical solids as a platform to improve solubility and bioavailability
    Kuthuru Suresh, Ashwini Kumar Nangia · 2018 · CrystEngComm
31. Co-localized delivery of nanomedicine and nanovaccine augments the postoperative cancer immunotherapy by amplifying T-cell responses
    Xiang Liu, Zujian Feng, Changrong Wang, Qi Su, Huijuan Song, Chuangnian Zhang, Pingsheng Huang, Xing‐Jie Liang, Anjie Dong, Deling Kong et al. · 2019 · Biomaterials
32. Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases
    Samanta Celeste Funes, Mariana Ríos, Ayleen Fernández‐Fierro, Camila Covián, Susan M. Bueno, Claudia A. Riedel, Juan Pablo Mackern‐Oberti, Alexis M. Kalergis · 2020 · Frontiers in Immunology
33. Biological properties and therapeutic effects of plant-derived nanovesicles
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34. Conjugation of curcumin with PVP capped gold nanoparticles for improving bioavailability
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35. Safety and Efficacy of Nanocurcumin as Add-On Therapy to Riluzole in Patients With Amyotrophic Lateral Sclerosis: A Pilot Randomized Clinical Trial
    Mona Ahmadi, Elmira Agah, Shahriar Nafissi, Mahmoud Reza Jaafari, Mohammad Hossein Harirchian, Payam Sarraf, Sara Faghihi‐Kashani, Seyed Jalal Hosseini, Abdoreza Ghoreishi, Vajiheh Aghamollaii et al. · 2018 · Neurotherapeutics
36. Pectin polymers for colon-targeted antitumor drug delivery
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37. Dendrosomal curcumin significantly suppresses cancer cell proliferation in vitro and in vivo
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38. Curcumin Inhibits the Activity of ABCG2/BCRP1, a Multidrug Resistance-Linked ABC Drug Transporter in Mice
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39. A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases
    Derek Martin, Bradley W. Bolling · 2015 · Food & Function
40. Synthesis of Novel Biodegradable Methoxy Poly(ethylene glycol)–Zein Micelles for Effective Delivery of Curcumin
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41. Mucoadhesive curcumin nanospheres: Biological activity, adhesion to stomach mucosa and release of curcumin into the circulation
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42. Skin regenerative potentials of curcumin
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43. Curcumin nanodisks: formulation and characterization
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44. Curcumin induces cell‐arrest and apoptosis in association with the inhibition of constitutively active NF‐κB and STAT3 pathways in Hodgkin's lymphoma cells
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45. Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) as Food-Grade Nanovehicles for Hydrophobic Nutraceuticals or Bioactives
    Chuan‐He Tang, Huan-Le Chen, Jin-Ru Dong · 2023 · Applied Sciences
46. Anti-inflammatory properties of culinary herbs and spices that ameliorate the effects of metabolic syndrome
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47. Therapeutic targeting of liver inflammation and fibrosis by nanomedicine.
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48. Bioactivity of Turmeric-derived Curcuminoids and Related Metabolites in Breast Cancer
    Laura E. Wright, Jen B. Frye, Bhavana Gorti, Barbara N. Timmermann, Janet L. Funk · 2013 · Current Pharmaceutical Design
49. Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy
    Murielle Mimeault, Surinder K. Batra · 2011 · Chinese Medicine
50. Turmeric ( Curcuma longa ) inhibits inflammatory nuclear factor (NF)‐κB and NF‐κB‐regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis
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51. Effects of surfactants on the formation of gelatin nanofibres for controlled release of curcumin
    Lingli Deng, Xuefan Kang, Yuyu Liu, Fengqin Feng, Hui Zhang · 2017 · Food Chemistry
52. The Role of Curcumin in the Modulation of Ageing
    Anna Bielak-Żmijewska, Wioleta Grabowska, Agata Ciolko, Agnieszka Bojko, Grażyna Mosieniak, Łukasz Bijoch, Ewa Sikora · 2019 · International Journal of Molecular Sciences
53. Curcumin encapsulation in functional PLGA nanoparticles: A promising strategy for cancer therapies
    Felipe da Silva Feltrin, Tamara Agner, Cláudia Sayer, Liliane Maria Ferrareso Lona · 2021 · Advances in Colloid and Interface Science
54. Phytochemicals As Chemosensitizers: From Molecular Mechanism to Clinical Significance
    Vinod Balachandran, Tessy Thomas Maliekal, Ruby John Anto · 2012 · Antioxidants and Redox Signaling
55. SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: An insight into its mechanism for neuroprotection
    Rayanta P. Joshi, Geeta Negi, Ashutosh Kumar, Yogesh B. Pawar, Bhushan Munjal, Arvind K. Bansal, Shyam Sunder Sharma · 2013 · Nanomedicine Nanotechnology Biology and Medicine
56. Preparation and in vivo pharmacokinetics of curcumin-loaded PCL-PEG-PCL triblock copolymeric nanoparticles
    Runliang Feng, Zhimei Song, Guangxi Zhai · 2012 · International Journal of Nanomedicine
57. Modulation of the Photophysical Properties of Curcumin in Nonionic Surfactant (Tween-20) Forming Micelles and Niosomes: A Comparative Study of Different Microenvironments
    Sarthak Mandal, Chiranjib Banerjee, Surajit Ghosh, Jagannath Kuchlyan, Nilmoni Sarkar · 2013 · The Journal of Physical Chemistry B
58. How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies
    Liang Shen, Cuicui Liu, Chun-Yan An, Hong‐Fang Ji · 2016 · Scientific Reports
59. Injectable and In Situ-Formable Thiolated Chitosan-Coated Liposomal Hydrogels as Curcumin Carriers for Prevention of In Vivo Breast Cancer Recurrence
    Riwang Li, Zhen Lin, Qian Zhang, Yuhui Zhang, Yi Liu, Yang Lyu, Xinyang Li, Changren Zhou, Gang Wu, Ningjian Ao et al. · 2020 · ACS Applied Materials & Interfaces
60. Curcumin Inhibits Proliferation and Induces Apoptosis of Human Colorectal Cancer Cells by Activating the Mitochondria Apoptotic Pathway
    Lida Guo, Xuejie Chen, Yuhong Hu, Zhijun Yu, Duo Wang, Jingze Liu · 2012 · Phytotherapy Research
61. Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4?
    Melissa D. Laird, Sangeetha Sukumari-Ramesh, A. Swift, Steffen E. Meiler, J. Vender, K. Dhandapani · 2010 · Journal of Neurochemistry
62. Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of curcumin
    Mehmet Hikmet Üçışık, Seta Küpcü, Bernhard Schuster, Uwe B. Sleytr · 2013 · Journal of Nanobiotechnology
63. Green synthesis and characterization of Manganese nanoparticles using natural plant extracts and its evaluation of antimicrobial activity
    M. Jayandran, M. Muhamed Haneefa, V. Balasubramanian · 2015 · Journal of Applied Pharmaceutical Science
64. Nanocurcumin is superior to native curcumin in preventing degenerative changes in Experimental Cerebral Malaria
    Chaitanya Dende, Jairam Meena, Perumal Nagarajan, Viswanathan Arun Nagaraj, Amulya Kumar Panda, Govindarajan Padmanaban · 2017 · Scientific Reports
65. EGFR-targeting PLGA-PEG nanoparticles as a curcumin delivery system for breast cancer therapy
    Hua Jin, Jiang Pi, Yue Zhao, Jinhuan Jiang, Ting Li, Xueyi Zeng, Peihui Yang, Colin E. Evans, Jiye Cai · 2017 · Nanoscale
66. Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells
    K. T. Kazantzis, K. Koutsonikoli, Barbara Mavroidi, Michael Zachariadis, P. Alexiou, Maria Pelecanou, Konstantinos Politopoulos, Eleni Alexandratou, Marina Sagnou · 2020 · Photochemical & Photobiological Sciences
67. Curcumin blocks brain tumor formation
    Sudarshana Purkayastha, Alexandra Berliner, Suraj Shawn Fernando, Buddima Ranasinghe, Indrani Ray, Hussnain Tariq, Probal Banerjee · 2009 · Brain Research
68. Novel curcumin-loaded gel-core hyaluosomes with promising burn-wound healing potential: Development, in-vitro appraisal and in-vivo studies
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69. Fast dissolving eutectic compositions of curcumin
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70. Encapsulation of curcumin in recombinant human H-chain ferritin increases its water-solubility and stability
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71. Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells
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72. Scale up, optimization and stability analysis of Curcumin C3 complex-loaded nanoparticles for cancer therapy
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73. Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells
    Majid Sadeghizadeh, Maryam Tahmasebi Birgani, Isacchi, Fabio Marra, Anna Rita Bilia, Seyed Javad Mowla, Farhood Najafi, Esmaeil Babaei · 2014 · International Journal of Nanomedicine
74. Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells
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75. Neurogenesis in the aging brain
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76. Biocompatible Polyelectrolyte Complex Nanoparticles from Lactoferrin and Pectin as Potential Vehicles for Antioxidative Curcumin
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77. A New Venue of TNF Targeting
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78. Curcumin-Based Nanoformulations: A Promising Adjuvant towards Cancer Treatment
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79. Soluble soybean polysaccharide/gelatin active edible films incorporated with curcumin for oil packaging
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80. Bioavailability of dietary polyphenols: Factors contributing to their clinical application in CNS diseases
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81. Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device
    Gao, Dan, Liu, Hongxia, Lin, Jin-Ming, Wang, Yini, Jiang, Yuyang · 2013 · Lab on a Chip
82. Curcumin Conjugated Silica Nanoparticles for Improving Bioavailability and Its Anticancer Applications
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83. Phytochemicals in Wound Healing
    Rajesh L. Thangapazham, Shashwat Sharad, Radha K. Maheshwari · 2014 · Advances in Wound Care
84. Binding of curcumin to β-lactoglobulin and its effect on antioxidant characteristics of curcumin
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85. Passively Targeted Curcumin-Loaded PEGylated PLGA Nanocapsules for Colon Cancer Therapy In Vivo
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86. Difluorinated-Curcumin (CDF): A Novel Curcumin Analog is a Potent Inhibitor of Colon Cancer Stem-Like Cells
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87. Improvement in oxidative stress and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids
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88. Inclusion Complex of Novel Curcumin Analogue CDF and β-Cyclodextrin (1:2) and Its Enhanced In Vivo Anticancer Activity Against Pancreatic Cancer
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89. Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review
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90. Phenolic and Enolic Hydroxyl Groups in Curcumin: Which Plays the Major Role in Scavenging Radicals?
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91. Simultaneous delivery of doxorubicin and curcumin encapsulated in liposomes of pegylated RGDK-lipopeptide to tumor vasculature
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92. Synergistic enhancement of tendon-to-bone healing via anti-inflammatory and pro-differentiation effects caused by sustained release of Mg 2+ /curcumin from injectable self-healing hydrogels
    Baojun Chen, Yongping Liang, Jing Zhang, Lang Bai, Meiguang Xu, Qian Han, Xuezhe Han, Jintao Xiu, Meng Li, Xiaoling Zhou et al. · 2021 · Theranostics
93. Biocompatible and biodegradable nanoparticles for enhancement of anti-cancer activities of phytochemicals
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94. Effects of PCL, PEG and PLGA polymers on curcumin release from calcium phosphate matrix for in vitro and in vivo bone regeneration
    Susmita Bose, Naboneeta Sarkar, Dishary Banerjee · 2018 · Materials Today Chemistry
95. Multifunctional curcumin-loaded mesoporous silica nanoparticles for cancer chemoprevention and therapy
    Nihal Saad Elbialy, Samia Faisal O. Aboushoushah, Balsam Fahad Sofi, Abdulwahab A. Noorwali · 2019 · Microporous and Mesoporous Materials
96. Curcumin, an active component of turmeric: biological activities, nutritional aspects, immunological, bioavailability, and human health benefits - a comprehensive review
    Mohamed T. El‐Saadony, Ahmed M. Saad, Dina Mostafa Mohammed, Samar Sami Alkafaas, Soumya Bikash Ghosh, Shaimaa H. Negm, Heba Mohammed Salem, Mohamed A. Fahmy, Walid F. A. Mosa, Essam H. Ibrahim et al. · 2025 · Frontiers in Immunology
97. Poly(β‐cyclodextrin)/Curcumin Self‐Assembly: A Novel Approach to Improve Curcumin Delivery and its Therapeutic Efficacy in Prostate Cancer Cells
    Murali Mohan Yallapu, Meena Jaggi, Subhash C. Chauhan · 2010 · Macromolecular Bioscience
98. Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments
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99. Formulation design, production and characterisation of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the encapsulation of a model hydrophobic active
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100. PEGylated PLGA nanoparticles: unlocking advanced strategies for cancer therapy
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