The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Solid State Amorphization of Pharmaceuticals
Abstract
Amorphous solids are conventionally formed by supercooling liquids or by concentrating noncrystallizing solutes (spray-drying and freeze-drying). However, a lot of pharmaceutical processes may also directly convert compounds from crystal to noncrystal which may have desired or undesired consequences for their stability. The purpose of this short review paper is (i) to illustrate the possibility to amorphize one compound by several different routes (supercooling, dehydration of hydrate, milling, annealing of metastable crystalline forms), (ii) to examine factors that favor crystal to glass rather than crystal to crystal transformations, (iii) to discuss the role of possible amorphous intermediates in solid-solid conversions induced by milling, (iv) to address the issue of chemical stability in the course of solid state amorphization, (v) to discuss the nature of the amorphous state obtained by the nonconventional routes, (vi) to show the effect of milling conditions on glasses properties, and (vii) to attempt to rationalize the observed transformations using the concepts of effective temperature introduced in nonequilibrium physics.
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Citations
Cites
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Characteristics and Significance of the Amorphous State in Pharmaceutical Systems
Hancock, B. C., & Zografi, G. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js9601896 · Cited by 1,922
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Debenedetti, P. G. (1996) · Cited by 1,468
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Interpretation of Relaxation Time Constants for Amorphous Pharmaceutical Systems
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Cited by
Review: physical chemistry of solid dispersions
Janssens, S., & Van den Mooter, G. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.61.12.0001 · Cited by 580
Structural Analysis of Molecular Materials Using the Pair Distribution Function
Terban, M. W., & Billinge, S. J. L. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00237 · Cited by 426
Wang, M., Wang, J., Zhang, Y., Xia, Q., Bi, W., Yang, X., & Chen, D. D. Y. (2016) · Journal of Chromatography A · doi:10.1016/j.chroma.2016.03.061 · Cited by 108
Smith, G., Hussain, A., Bukhari, N. I., & Ermolina, I. (2015) · Journal of Thermal Analysis and Calorimetry · doi:10.1007/s10973-015-4469-4 · Cited by 18
Metadata
- Authors
- Willart, J. F., & Descamps, M.
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-10-28
- Volume
- 5
- Issue
- 6
- Pages
- 905-920
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W1965469157
- Cited by
- 332
- References
- 19
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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