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Sequence-Specific Label-Free DNA Sensors Based on Silicon Nanowires
Abstract
Highly sensitive and sequence-specific DNA sensors were fabricated based on silicon nanowires (SiNWs) with single stranded (ss) probe DNA molecules covalently immobilized on the nanowire surfaces. Label-free complementary (target) ss-DNA in sample solutions were recognized when the target DNA was hybridized with the probe DNA attached on the SiNW surfaces, producing a change of the conductance of the SiNWs. For a 12-mer oligonucletide probe, 25 pM of target DNA in solution was detected easily (signal/noise ratio > 6), whereas 12-mers with one base mismatch did not produce a signal above the background noise.
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Cites
Enzyme-coated carbon nanotubes as single-molecule biosensors
Besteman, K., Lee, J.-O., Wiertz, F. G. M., Heering, H. A., & Dekker, C. (2003) · Nano Letters · doi:10.1021/nl034139u · Cited by 1,294
Cited by
Label-free immunodetection with CMOS-compatible semiconducting nanowires
Stern, E., Klemic, J. F., Routenberg, D. A., Wyrembak, P. N., Turner-Evans, D. B., Hamilton, A. D., LaVan, D. A., Fahmy, T. M., & Reed, M. A. (2007) · Nature · doi:10.1038/nature05498 · Cited by 1,352
Subthreshold Regime has the Optimal Sensitivity for Nanowire FET Biosensors
Gao, X. P. A., Zheng, G., & Lieber, C. M. (2010) · Nano Letters · doi:10.1021/nl9034219 · Cited by 571
Dielectric modulated junctionless biotube FET (DM-JL-BT-FET) Bio-Sensor
Goel, A., Rewari, S., Verma, S., Deswal, S. S., & Gupta, R. S. (2021) · IEEE Sensors Journal · doi:10.1109/jsen.2021.3077540 · Cited by 69
Metadata
- Authors
- Li, Z., Chen, Y., Li, X., Kamins, T. I., Nauka, K., & Williams, R. S.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-01-08
- Volume
- 4
- Issue
- 2
- Pages
- 245-247
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2055307846
- Cited by
- 706
- References
- 1
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, Z., Chen, Y., Li, X., Kamins, T. I., Nauka, K., & Williams, R. S. (2004). Sequence-Specific Label-Free DNA Sensors Based on Silicon Nanowires. Nano Letters. https://doi.org/10.1021/nl034958e
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
