The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Differential Cytotoxicity of Water-Soluble Fullerenes
Abstract
We show that the cytotoxicity of water-soluble fullerene species is a sensitive function of surface derivatization; in two different human cell lines, the lethal dose of fullerene changed over 7 orders of magnitude with relatively minor alterations in fullerene structure. In particular, an aggregated form of C 60, the least derivatized of the four materials, was substantially more toxic than highly soluble derivatives such as C 3, Na + 2 - 3 [C 60 O 7 - 9 (OH) 12 - 15 ] (2-3)-, and C 60 (OH) 24 . Oxidative damage to the cell membranes was observed in all cases where fullerene exposure led to cell death. We show that under ambient conditions in water fullerenes can generate superoxide anions and postulate that these oxygen radicals are responsible for membrane damage and subsequent cell death. This work demonstrates both a strategy for enhancing the toxicity of fullerenes for certain applications such as cancer therapeutics or bactericides, as well as a remediation for the possible unwarranted biological effects of pristine fullerenes.
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Cites
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
Buettner, G. R. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1074 · Cited by 2,417
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Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
Oberdörster, G., Oberdörster, E., & Oberdörster, J. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7339 · Cited by 7,891
Understanding biophysicochemical interactions at the nano–bio interface
Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009) · Nature Materials · doi:10.1038/nmat2442 · Cited by 7,083
Nanomaterials and nanoparticles: Sources and toxicity
Buzea, C., Pacheco, I. I., & Robbie, K. (2007) · Biointerphases · doi:10.1116/1.2815690 · Cited by 3,789
Nanomaterials in the environment: Behavior, fate, bioavailability, and effects
Klaine, S. J., Alvarez, P. J. J., Batley, G. E., Fernandes, T. F., Handy, R. D., Lyon, D. Y., Mahendra, S., McLaughlin, M. J., & Lead, J. R. (2008) · Environmental Toxicology and Chemistry · doi:10.1897/08-090.1 · Cited by 2,764
Self-citationLi, Q., Mahendra, S., Lyon, D. Y., Brunet, L., Liga, M. V., Li, D., & Alvarez, P. J. J. (2008) · Water Research · doi:10.1016/j.watres.2008.08.015 · Cited by 2,385
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Metadata
- Authors
- Sayes, C. M., Fortner, J. D., Guo, W., Lyon, D., Boyd, A. M., Ausman, K. D., Tao, Y. J., Sitharaman, B., Wilson, L. J., Hughes, J. B., West, J. L., & Colvin, V. L.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-09-11
- Volume
- 4
- Issue
- 10
- Pages
- 1881-1887
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2102122862
- Cited by
- 1,087
- References
- 1
- FWCI
- 37.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sayes, C. M., Fortner, J. D., Guo, W., Lyon, D., Boyd, A. M., Ausman, K. D., Tao, Y. J., Sitharaman, B., Wilson, L. J., Hughes, J. B., West, J. L., & Colvin, V. L. (2004). The Differential Cytotoxicity of Water-Soluble Fullerenes. Nano Letters. https://doi.org/10.1021/nl0489586
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