The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Controllable Self-Assembly of Nanoparticles for Specific Delivery of Multiple Therapeutic Molecules to Cancer Cells Using RNA Nanotechnology
Open accessAbstract
By utilizing RNA nanotechnology, we engineered both therapeutic siRNA and a receptor-binding RNA aptamer into individual pRNAs of phi29's motor. The RNA building block harboring siRNA or other therapeutic molecules was fabricated subsequently into a trimer through the interaction of engineered right and left interlocking RNA loops. The incubation of the protein-free nanoscale particles containing the receptor-binding aptamer or other ligands resulted in the binding and co-entry of the trivalent therapeutic particles into cells, subsequently modulating the apoptosis of cancer cells and leukemia model lymphocytes in cell culture and animal trials. The use of such antigenicity-free 20-40 nm particles holds promise for the repeated long-term treatment of chronic diseases.
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Cites
Letai, A., Bassik, M. C., Walensky, L. D., Sorcinelli, M. D., Weiler, S., & Korsmeyer, S. J. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00127-7 · Cited by 1,677
Cited by
Dahl, J. A., Maddux, B. L. S., & Hutchison, J. E. (2007) · Chemical Reviews · doi:10.1021/cr050943k · Cited by 1,284
The emerging field of RNA nanotechnology
Guo, P. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.231 · Cited by 718
Self-citationPi, F., Binzel, D. W., Lee, T. J., Li, Z., Sun, M., Rychahou, P., Li, H., Haque, F., Wang, S., Croce, C. M., et al. (2018) · Nature Nanotechnology · doi:10.1038/s41565-017-0012-z · Cited by 494
Self-citationShu, D., Shu, Y., Haque, F., Abdelmawla, S., & Guo, P. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.105 · Cited by 435
Self-citationA review of nanocarriers for the delivery of small interfering RNA
Kesharwani, P., Gajbhiye, V., & Jain, N. K. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.068 · Cited by 368
Metadata
- Authors
- Khaled, A., Guo, S., Li, F., & Guo, P.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-09-01
- Volume
- 5
- Issue
- 9
- Pages
- 1797-1808
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2136991395
- Cited by
- 233
- References
- 1
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- green
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