The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Functionalized Carbon Nanotubes Are Non-Cytotoxic and Preserve the Functionality of Primary Immune Cells
Abstract
Carbon nanotubes are emerging as innovative tools in nanobiotechnology. However, their toxic effects on environment and health have become an issue of strong concern. In the present study, we address the impact of functionalized carbon nanotubes (f-CNTs) on cells of the immune system. We have prepared two types of f-CNTs, following the 1,3-dipolar cycloaddition reaction (f-CNTs 1 and 2) and the oxidation/amidation treatment (f-CNTs 3 and 4), respectively. We have found that both types of f-CNTs are uptaken by B and T lymphocytes as well as macrophages in vitro, without affecting cell viability. Subsequently, the functionality of the different cells was analyzed carefully. We discovered that f-CNT 1, which is highly water soluble, did not influence the functional activity of immunoregulatory cells. f-CNT 3, which instead possesses reduced solubility and forms mainly stable water suspensions, preserved lymphocytes' functionality while provoking secretion of proinflammatory cytokines by macrophages.
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Cites
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Self-citationDNA-assisted dispersion and separation of carbon nanotubes
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Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery
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Self-citationFunctionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro
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Hu, B., Wang, K., Wu, L., Yu, S., Antonietti, M., & Titirici, M. (2010) · Advanced Materials · doi:10.1002/adma.200902812 · Cited by 1,765
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Toxicity and Environmental Risks of Nanomaterials: Challenges and Future Needs
RAY, P. C., YU, H., & FU, P. P. (2009) · Journal of Environmental Science and Health, Part C · doi:10.1080/10590500802708267 · Cited by 936
Bhirde, A. A., Patel, V., Gavard, J., Zhang, G., Sousa, A. A., Masedunskas, A., Leapman, R. D., Weigert, R., Gutkind, J. S., & Rusling, J. F. (2009) · ACS Nano · doi:10.1021/nn800551s · Cited by 853
siRNA Delivery into Human T Cells and Primary Cells with Carbon‐Nanotube Transporters
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Metadata
- Authors
- Dumortier, H., Lacotte, S., Pastorin, G., Marega, R., Wu, W., Bonifazi, D., Briand, J.-P., Prato, M., Muller, S., & Bianco, A.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-06-23
- Volume
- 6
- Issue
- 7
- Pages
- 1522-1528
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2043933297
- Cited by
- 697
- References
- 24
- FWCI
- 33.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dumortier, H., Lacotte, S., Pastorin, G., Marega, R., Wu, W., Bonifazi, D., Briand, J.-P., Prato, M., Muller, S., & Bianco, A. (2006). Functionalized Carbon Nanotubes Are Non-Cytotoxic and Preserve the Functionality of Primary Immune Cells. Nano Letters. https://doi.org/10.1021/nl061160x
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