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Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery
Abstract
Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA–nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.
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Citations
Cited by
Nonviral vectors for gene delivery
Mintzer, M. A., & Simanek, E. E. (2009) · Chemical Reviews · doi:10.1021/cr800409e · Cited by 2,366
Oops they did it again! Carbon nanotubes hoax scientists in viability assays
Wörle-Knirsch, J. M., Pulskamp, K., & Krug, H. F. (2006) · Nano Letters · doi:10.1021/nl060177c · Cited by 994
Green chemistry and the health implications of nanoparticles
Albrecht, M. A., Evans, C. W., & Raston, C. L. (2006) · Green Chemistry · doi:10.1039/b517131h · Cited by 746
Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery
Panwar, N., Soehartono, A. M., Chan, K. K., Zeng, S., Xu, G., Qu, J., Coquet, P., Yong, K.-T., & Chen, X. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00099 · Cited by 555
Gold Nanoparticles for Nucleic Acid Delivery
Ding, Y., Jiang, Z., Saha, K., Kim, C. S., Kim, S. T., Landis, R. F., & Rotello, V. M. (2014) · Molecular Therapy · doi:10.1038/mt.2014.30 · Cited by 521
Metadata
- Authors
- Pantarotto, D., Singh, R., McCarthy, D., Erhardt, M., Briand, J., Prato, M., Kostarelos, K., & Bianco, A.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2004-09-29
- Volume
- 43
- Issue
- 39
- Pages
- 5242-5246
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2170529786
- Cited by
- 1,091
- References
- 0
- FWCI
- 14.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pantarotto, D., Singh, R., McCarthy, D., Erhardt, M., Briand, J., Prato, M., Kostarelos, K., & Bianco, A. (2004). Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200460437
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