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Cellular Uptake and Cytotoxicity of Silica Nanotubes
Abstract
"Template synthesized" silica nanotubes (SNTs) provide unique features such as end functionalization to control drug release, inner voids for loading biomolecules, and distinctive inner and outer surfaces that can be differentially functionalized for targeting and biocompatibility. Very limited information is available about their biological interactions. This work evaluates the influence of size and surface charge of SNTs on cellular toxicity and uptake. Results additionally indicate endocytosis to be one possible mechanism of internalization of SNTs.
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Cited by
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Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859
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Klemm, D., Cranston, E. D., Fischer, D., Gama, M., Kedzior, S. A., Kralisch, D., Kramer, F., Kondo, T., Lindström, T., Nietzsche, S., et al. (2018) · Materials Today · doi:10.1016/j.mattod.2018.02.001 · Cited by 936
Duan, X., & Li, Y. (2013) · Small · doi:10.1002/smll.201201390 · Cited by 926
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Self-citationBerg, J. M., Romoser, A., Banerjee, N., Zebda, R., & Sayes, C. M. (2009) · Nanotoxicology · doi:10.3109/17435390903276941 · Cited by 364
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Self-citationCytotoxicity of hydroxyapatite nanoparticles is shape and cell dependent
Zhao, X., Ng, S., Heng, B. C., Guo, J., Ma, L., Tan, T. T. Y., Ng, K. W., & Loo, S. C. J. (2013) · Archives of Toxicology · doi:10.1007/s00204-012-0827-1 · Cited by 299
Cytotoxicity and mitochondrial damage caused by silica nanoparticles
Sun, L., Li, Y., Liu, X., Jin, M., Zhang, L., Du, Z., Guo, C., Huang, P., & Sun, Z. (2011) · Toxicology in Vitro · doi:10.1016/j.tiv.2011.06.012 · Cited by 263
Venkatesan, P., Puvvada, N., Dash, R., Prashanth Kumar, B. N., Sarkar, D., Azab, B., Pathak, A., Kundu, S. C., Fisher, P. B., & Mandal, M. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.027 · Cited by 262
Metadata
- Authors
- Nan, A., Bai, X., Son, S. J., Lee, S. B., & Ghandehari, H.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-12
- Volume
- 8
- Issue
- 8
- Pages
- 2150-2154
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1981937857
- Cited by
- 212
- References
- 0
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- closed
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