Cellular uptake of nanoparticles: Journey inside the cell
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Cellular association and trafficking of nanoscale materials enables us to both understand and exploit context-dependent phenomena in various disease states, their pathogenesis, and potential therapeutic approaches.
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The fate of encapsulated mRNA is not clear; as extracellular vesicles surround the lipid nanoparticle, synthetic mRNA may be isolated and destroyed by lysosomal degradation enzymes.
“Yet, the fate of encapsulated mRNA is not clear. As extracellular vesicles surround the lipid nanoparticle, synthetic mRNA may be isolated and destroyed by lysosomal degradation enzymes [43].”
From Relative risk reduction: Misinformative measure in clinical trials and COVID-19 vaccine efficacy (2022) · cites this paper as [43]
Section 6, “Intracellular trafficking” (page unavailable), says endocytic vesicles can carry nanoparticles to lysosomes, where their contents encounter degradation enzymes; nanoparticles that escape first may avoid degradation. It does not address encapsulated synthetic mRNA specifically or say that extracellular vesicles surround lipid nanoparticles. (LLM, conf=0.86)
Experimental — accuracy not yet measuredNanoparticles that undergo clathrin-mediated endocytosis can end up in endosomes, which mature to endolysosomes and undergo degradation.
“The NPs that undergo clathrin-mediated endocytosis can end up in endosomes, which mature to endolysosomes and undergo degradation.”
From The Ocular Gene Delivery Landscape (2021) · cites this paper as [30]
Caveolin-mediated endocytosis encapsulates nanoparticles in caveolae vesicles that enter early endosomes or endoplasmic reticulum and escape degradation.
“However, caveolin-mediated endocytosis encapsulates the NPs in caveolae vesicles that enter early endosomes or endoplasmic reticulum and escape degradation [30].”
From The Ocular Gene Delivery Landscape (2021) · cites this paper as [30]
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Cites
Understanding biophysicochemical interactions at the nano–bio interface
Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009) · Nature Materials · doi:10.1038/nmat2442 · Cited by 7,083 · see citing works
Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002 · see citing works
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565 · see citing works
Cancer nanomedicine: progress, challenges and opportunities
Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873 · see citing works
Self-citationMechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,860 · see citing works
Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells
Chithrani, D. B., Ghazani, A. A., & Chan, W. C. W. (2006) · Nano Letters · doi:10.1021/nl052396o · Cited by 4,887 · see citing works
Doxil® — The first FDA-approved nano-drug: Lessons learned
Barenholz, Y. (. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.020 · Cited by 4,792 · see citing works
Autophagy: process and functionPreprint
Mizushima, N. (2007) · Genes & Development · doi:10.1101/gad.1599207 · Cited by 3,964 · see citing works
Regulated portals of entry into the cell
Conner, S. D., & Schmid, S. L. (2003) · Nature · doi:10.1038/nature01451 · Cited by 3,816 · see citing works
Strategies in the design of nanoparticles for therapeutic applications
Petros, R. A., & DeSimone, J. M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2591 · Cited by 3,651 · see citing works
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
OWENSIII, D., & PEPPAS, N. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.010 · Cited by 3,637 · see citing works
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521 · see citing works
Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305 · see citing works
Doherty, G. J., & McMahon, H. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081307.110540 · Cited by 3,075 · see citing works
The effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918 · see citing works
Mechanisms of phagocytosis in macrophages
Aderem, A., & Underhill, D. M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.593 · Cited by 2,854 · see citing works
Nanoparticle-mediated cellular response is size-dependent
Jiang, W., Kim, B. Y. S., Rutka, J. T., & Chan, W. C. W. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.30 · Cited by 2,781 · see citing works
Effect of Surface Properties on Nanoparticle–Cell Interactions
Verma, A., & Stellacci, F. (2009) · Small · doi:10.1002/smll.200901158 · Cited by 2,621 · see citing works
Huotari, J., & Helenius, A. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.286 · Cited by 2,279 · see citing works
Chithrani, D. B., & Chan, W. C. W. (2007) · Nano Letters · doi:10.1021/nl070363y · Cited by 2,274 · see citing works
Caveolin, a protein component of caveolae membrane coats
Rothberg, K. G., Heuser, J. E., Donzell, W. C., Ying, Y., Glenney, J. R., & Anderson, R. G. W. (1992) · Cell · doi:10.1016/0092-8674(92)90143-z · Cited by 2,259 · see citing works
Membrane curvature and mechanisms of dynamic cell membrane remodelling
McMahon, H., & Gallop, J. (2005) · Nature · doi:10.1038/nature04396 · Cited by 2,212 · see citing works
Sahay, G., Alakhova, D. Y., & Kabanov, A. V. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.01.036 · Cited by 2,181 · see citing works
Anderson, R. G. W. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.199 · Cited by 1,941 · see citing works
Mahmoudi, M., Sant, S., Wang, B., Laurent, S., & Sen, T. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.05.006 · Cited by 1,888 · see citing works
Self-citationWalkey, C. D., & Chan, W. C. W. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15233e · Cited by 1,758 · see citing works
Lichtman, J. W., & Conchello, J.-A. (2005) · Nature Methods · doi:10.1038/nmeth817 · Cited by 1,751 · see citing works
Gilleron, J., Querbes, W., Zeigerer, A., Borodovsky, A., Marsico, G., Schubert, U., Manygoats, K., Seifert, S., Andree, C., Stöter, M., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2612 · Cited by 1,681 · see citing works
Nanocarriers’ entry into the cell: relevance to drug delivery
Hillaireau, H., & Couvreur, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0053-z · Cited by 1,549 · see citing works
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Zangabad, P. S., Rahighi, R., Basri, S. M. M., Mirshekari, H., Amiri, M., Shafaei, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,526 · see citing works
Prabhakar, U., Maeda, H., Jain, R. K., Sevick-Muraca, E. M., Zamboni, W. C., Farokhzad, O. C., Barry, S. T., Gabizón, A., Grodzinski, P. A., & Blakey, D. C. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4561 · Cited by 1,489 · see citing works
Self-citationPathways and mechanisms of endocytic recycling
Grant, B. D., & Donaldson, J. G. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2755 · Cited by 1,468 · see citing works
Sharifi, S., Behzadi, S., Laurent, S., Laird Forrest, M., Stroeve, P., & Mahmoudi, M. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15188f · Cited by 1,460 · see citing works
Self-citationThe multiple faces of caveolae
Parton, R. G., & Simons, K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2122 · Cited by 1,456 · see citing works
Nanoparticle uptake: The phagocyte problem
Gustafson, H. H., Holt‐Casper, D., Grainger, D. W., & Ghandehari, H. (2015) · Nano Today · doi:10.1016/j.nantod.2015.06.006 · Cited by 1,424 · see citing works
Geiser, M., Rothen‐Rutishauser, B., Kapp, N., Schürch, S., Kreyling, W. G., Schulz, H., Semmler, M., Hof, V. I., Heyder, J., & Gehr, P. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8006 · Cited by 1,408 · see citing works
The dynamin superfamily: universal membrane tubulation and fission molecules?
Praefcke, G. J. K., & McMahon, H. T. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1313 · Cited by 1,380 · see citing works
Contrast agents for molecular photoacoustic imaging
Weber, J., Beard, P. C., & Bohndiek, S. E. (2016) · Nature Methods · doi:10.1038/nmeth.3929 · Cited by 1,276 · see citing works
What the Cell “Sees” in Bionanoscience
Dorota, W., Bombelli, F. B., Monopoli, M. P., Lynch, I., & Dawson, K. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja910675v · Cited by 1,188 · see citing works
Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials
Zhao, F., Zhao, Y., Liu, Y., Chang, X., Chen, C., & Zhao, Y. (2011) · Small · doi:10.1002/smll.201100001 · Cited by 1,179 · see citing works
Phagocytosis of Microbes: Complexity in Action
Underhill, D. M., & Ozinsky, A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.103001.114744 · Cited by 1,124 · see citing works
Leśniak, A., Fenaroli, F., Monopoli, M. P., Åberg, C., Dawson, K. A., & Salvati, A. L. (2012) · ACS Nano · doi:10.1021/nn300223w · Cited by 1,064 · see citing works
Nanotechnology: Intelligent Design to Treat Complex Disease
Couvreur, P., & Vauthier, C. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-0284-8 · Cited by 950 · see citing works
Shaping cups into phagosomes and macropinosomes
Swanson, J. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2447 · Cited by 941 · see citing works
Binding of blood proteins to carbon nanotubes reduces cytotoxicity
Ge, C., Du, J., Zhao, L., Wang, L., Liu, Y., Li, D., Yang, Y., Zhou, R., Zhao, Y., Chai, Z., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105270108 · Cited by 938 · see citing works
Caveolae as plasma membrane sensors, protectors and organizers
Parton, R. G., & del Pozo, M. Á. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3512 · Cited by 928 · see citing works
Nanomaterials: Applications in Cancer Imaging and Therapy
Barreto, J. A., O’Malley, W., Kubeil, M., Graham, B., Stephan, H., & Spiccia, L. (2011) · Advanced Materials · doi:10.1002/adma.201100140 · Cited by 905 · see citing works
Endocytosis by Random Initiation and Stabilization of Clathrin-Coated Pits
Ehrlich, M., Boll, W., van Oijen, A. M., Hariharan, R., Chandran, K., Nibert, M. L., & Kirchhausen, T. L. (2004) · Cell · doi:10.1016/j.cell.2004.08.017 · Cited by 888 · see citing works
Effect of Gold Nanoparticle Aggregation on Cell Uptake and Toxicity
Albanese, A., & Chan, W. C. W. (2011) · ACS Nano · doi:10.1021/nn2007496 · Cited by 850 · see citing works
Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation
Dominguez, A. A., Lim, W. A., & Qi, L. S. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.2 · Cited by 832 · see citing works
Cho, E. C., Xie, J., Wurm, P. A., & Younan Xia, A. (2009) · Nano Letters · doi:10.1021/nl803487r · Cited by 820 · see citing works
Virus entry by macropinocytosis
Mercer, J., & Helenius, A. (2009) · Nature Cell Biology · doi:10.1038/ncb0509-510 · Cited by 814 · see citing works
Strategies for the intracellular delivery of nanoparticles
Chou, L. Y. T., Ming, K., & Chan, W. C. W. (2010) · Chemical Society Reviews · doi:10.1039/c0cs00003e · Cited by 813 · see citing works
Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate
Zhu, M., Nie, G., Meng, H., Xia, T., Nel, A. E., & Zhao, Y. (2012) · Accounts of Chemical Research · doi:10.1021/ar300031y · Cited by 806 · see citing works
The Evolution of the Protein Corona around Nanoparticles: A Test Study
Lundqvist, M., Stigler, J., Cedervall, T., Berggård, T., Flanagan, M. B., Lynch, I., Elia, G., & Dawson, K. A. (2011) · ACS Nano · doi:10.1021/nn202458g · Cited by 800 · see citing works
Insight into nanoparticle cellular uptake and intracellular targeting
Yameen, B., Choi, W. I., Vilos, C., Swami, A., Shi, J., & Farokhzad, O. C. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.038 · Cited by 789 · see citing works
Self-citationRole of nanoparticle size, shape and surface chemistry in oral drug delivery
Banerjee, A., Qi, J., Gogoi, R., Wong, J., & Mitragotri, S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.051 · Cited by 777 · see citing works
Atomic force microscopy as a multifunctional molecular toolbox in nanobiotechnology
Müller, D. J., & Dufrêne, Y. F. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.100 · Cited by 756 · see citing works
Pelkmans, L., & Helenius, A. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30501.x · Cited by 746 · see citing works
Swanson, J. A., & Watts, C. K. W. (1995) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)89101-1 · Cited by 735 · see citing works
The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles
Cho, E. C., Zhang, Q., & Younan Xia, A. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.58 · Cited by 721 · see citing works
Macropinocytosis: an endocytic pathway for internalising large gulps
Lim, J. P., & Gleeson, P. A. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2011.20 · Cited by 716 · see citing works
Yang, K., & Ma, Y. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.141 · Cited by 705 · see citing works
Hauck, T. S., Ghazani, A. A., & Chan, W. C. W. (2007) · Small · doi:10.1002/smll.200700217 · Cited by 692 · see citing works
Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods
Qiu, Y., Liu, Y., Wang, L., Xu, L., Bai, R., Ji, Y., Wu, X., Zhao, Y., Li, Y., & Chen, C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.06.051 · Cited by 691 · see citing works
Xia, T., Kovochich, M., Liong, M., Zink, J. I., & Nel, A. E. (2007) · ACS Nano · doi:10.1021/nn700256c · Cited by 685 · see citing works
Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs
Hafner, M., Niepel, M., Chung, M., & Sorger, P. K. (2016) · Nature Methods · doi:10.1038/nmeth.3853 · Cited by 681 · see citing works
Anti-proliferative activity of silver nanoparticles
Asharani, P. V., Hande, M. P., & Valiyaveettil, S. (2009) · BMC Cell Biology · doi:10.1186/1471-2121-10-65 · Cited by 663 · see citing works
Lin, J., Zhang, H., Chen, Z., & Zheng, Y. (2010) · ACS Nano · doi:10.1021/nn1010792 · Cited by 635 · see citing works
Breaking down the barriers: siRNA delivery and endosome escape
Domińska, M., & Dykxhoorn, D. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.066399 · Cited by 632 · see citing works
Ma, X., Wu, Y., Jin, S., Tian, Y., Zhang, X., Zhao, Y., Yu, L., & Liang, X. (2011) · ACS Nano · doi:10.1021/nn202155y · Cited by 629 · see citing works
Maiorano, G., Sabella, S., Sorce, B., Brunetti, V., Malvindi, M. A., Cingolani, R., & Pompa, P. P. (2010) · ACS Nano · doi:10.1021/nn101557e · Cited by 626 · see citing works
Effect of Nanoparticle Surface Charge at the Plasma Membrane and Beyond
Arvizo, R. R., Miranda, O. R., Thompson, M. A., Pabelick, C. M., Bhattacharya, R., Robertson, J. D., Rotello, V. M., Prakash, Y. S., & Mukherjee, P. (2010) · Nano Letters · doi:10.1021/nl101140t · Cited by 621 · see citing works
Shape Induced Inhibition of Phagocytosis of Polymer Particles
Champion, J. A., & Mitragotri, S. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9626-z · Cited by 618 · see citing works
Endocytosis unplugged: Multiple ways to enter the cell
Kumari, S., MG, S., & Mayor, S. (2010) · Cell Research · doi:10.1038/cr.2010.19 · Cited by 599 · see citing works
Hühn, D., Kantner, K., Geidel, C., Brandholt, S., Cock, I. D., Soenen, S. J., Rivera-Gil, P., Montenegro, J., Braeckmans, K., Müllen, K., et al. (2013) · ACS Nano · doi:10.1021/nn3059295 · Cited by 582 · see citing works
Membrane microdomains and caveolae
Kurzchalia, T. V., & Parton, R. G. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80061-1 · Cited by 579 · see citing works
In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells
Galanzha, E. I., Shashkov, E. V., Kelly, T. J., Kim, J.-W., Yang, L. P. H., & Zharov, V. P. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.333 · Cited by 576 · see citing works
Targeting of nanoparticles to the clathrin-mediated endocytic pathway
Harush-Frenkel, O., Debotton, N., Benita, S., & Altschuler, Y. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.135 · Cited by 564 · see citing works
Wide Varieties of Cationic Nanoparticles Induce Defects in Supported Lipid Bilayers
Leroueil, P. R., Berry, S. A., Duthie, K., Han, G., Rotello, V. M., McNerny, D. Q., Baker, J. R., Orr, B. G., & Holl, M. M. B. (2008) · Nano Letters · doi:10.1021/nl0722929 · Cited by 557 · see citing works
Lipids on the frontier: a century of cell-membrane bilayers
Edidin, M. A. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1102 · Cited by 555 · see citing works
Polymer-assisted fabrication of nanoparticles and nanocomposites
Rozenberg, B. A., & Tenne, R. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.07.004 · Cited by 545 · see citing works
Hong, J., Heller, D. A., Sharma, R., & Strano, M. S. (2009) · ACS Nano · doi:10.1021/nn800532m · Cited by 544 · see citing works
Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage
Tabata, Y., & Ikada, Y. (1988) · Biomaterials · doi:10.1016/0142-9612(88)90033-6 · Cited by 538 · see citing works
Yuan, Y., Mao, C., Du, X., Du, J., Wang, F., & Wang, J. (2012) · Advanced Materials · doi:10.1002/adma.201202296 · Cited by 531 · see citing works
Shape and Orientation Matter for the Cellular Uptake of Nonspherical Particles
Dasgupta, S., Auth, T., & Gompper, G. (2014) · Nano Letters · doi:10.1021/nl403949h · Cited by 531 · see citing works
Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages
Kuhn, D. A., Vanhecke, D., Michen, B., Blank, F., Gehr, P., Petri‐Fink, A., & Rothen‐Rutishauser, B. (2014) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.5.174 · Cited by 515 · see citing works
Wang, L., Liu, Y., Li, W., et al. (2010) · Nano Letters · doi:10.1021/nl103992v · Cited by 514 · see citing works
Kelemen, L. E. (2006) · International Journal of Cancer · doi:10.1002/ijc.21712 · Cited by 511 · see citing works
Computer simulation study of fullerene translocation through lipid membranes
Wong-ekkabut, J., Baoukina, S., Triampo, W., Tang, I., Tieleman, D. P., & Monticelli, L. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.130 · Cited by 507 · see citing works
Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine
Zhang, X., Xu, X., Bertrand, N., Pridgen, E. M., Swami, A., & Farokhzad, O. C. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.005 · Cited by 494 · see citing works
Self-citationPlasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes
Park, M., Salgado, J. M., Ostroff, L., Helton, T. D., Robinson, C. G., Harris, K. M., & Ehlers, M. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.040 · Cited by 493 · see citing works
Sönnichsen, C., & Alivisatos, A. P. (2004) · Nano Letters · doi:10.1021/nl048089k · Cited by 483 · see citing works
Light In and Sound Out: Emerging Translational Strategies for Photoacoustic Imaging
Zackrisson, S., van de Ven, S. M. W. Y., & Gambhir, S. S. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2387 · Cited by 480 · see citing works
In Vivo Molecular Probing of Cellular Compartments with Gold Nanoparticles and Nanoaggregates
Kneipp, J., Kneipp, H., McLaughlin, M. M., Brown, D., & Kneipp, K. D. (2006) · Nano Letters · doi:10.1021/nl061517x · Cited by 470 · see citing works
Self-citationNanoparticle-induced surface reconstruction of phospholipid membranes
Wang, B., Zhang, L., Bae, S. C., & Granick, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807296105 · Cited by 470 · see citing works
Panyam, J., & Labhasetwar, V. D. (2003) · Pharmaceutical Research · doi:10.1023/a:1022219003551 · Cited by 467 · see citing works
Clathrin- and caveolin-1–independent endocytosis
Damm, E.-M., Pelkmans, L., Kartenbeck, J., Mezzacasa, A., Kurzchalia, T. V., & Helenius, A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200407113 · Cited by 454 · see citing works
Cell-Penetrating Quantum Dots Based on Multivalent and Endosome-Disrupting Surface Coatings
Duan, H., & Nie, S. (2007) · Journal of the American Chemical Society · doi:10.1021/ja068158s · Cited by 450 · see citing works
dos Santos, T., Varela, J. A., Lynch, I., Salvati, A. L., & Dawson, K. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024438 · Cited by 445 · see citing works
Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles
Kirkham, M., Fujita, A., Chadda, R., Nixon, S. J., Kurzchalia, T. V., Sharma, D. K., Pagano, R. E., Hancock, J. F., Mayor, S., & Parton, R. G. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200407078 · Cited by 439 · see citing works
Assembly units of clathrin coats
Ungewickell, E. J., & Branton, D. (1981) · Nature · doi:10.1038/289420a0 · Cited by 426 · see citing works
Characteristics of a Membrane Reservoir Buffering Membrane Tension
Raucher, D., & Sheetz, M. P. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77040-2 · Cited by 418 · see citing works
The uptake and intracellular fate of PLGA nanoparticles in epithelial cells
Cartiera, M. S., Johnson, K. M., Rajendran, V., Caplan, M. J., & Saltzman, W. M. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.057 · Cited by 412 · see citing works
Norbury, C. C., Hewlett, L. J., Prescott, A. R., Shastri, N., & Watts, C. K. W. (1995) · Immunity · doi:10.1016/1074-7613(95)90067-5 · Cited by 410 · see citing works
Anderson, H. A., Chen, Y., & Norkin, L. C. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.11.1825 · Cited by 397 · see citing works
Hirst, J., & Robinson, M. S. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(98)00056-1 · Cited by 389 · see citing works
The coated pit and macropinocytic pathways serve distinct endosome populations
Hewlett, L. J., Prescott, A., & Watts, C. K. W. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.5.689 · Cited by 380 · see citing works
Raman and SERS microscopy for molecular imaging of live cells
Palonpon, A. F., Ando, J., Yamakoshi, H., Dodo, K., Sodeoka, M., Kawata, S., & Fujita, K. (2013) · Nature Protocols · doi:10.1038/nprot.2013.030 · Cited by 378 · see citing works
The early endosome: a busy sorting station for proteins at the crossroads.
Jović, M., Sharma, M., Rahajeng, J., & Caplan, S. (2010) · PubMed · doi:10.14670/hh-25.99 · Cited by 377 · see citing works
Schnitzer, J. E., Liu, J., & Oh, P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.24.14399 · Cited by 371 · see citing works
Single-cell technologies for monitoring immune systems
Chattopadhyay, P. K., Gierahn, T. M., Roederer, M., & Love, J. C. (2014) · Nature Immunology · doi:10.1038/ni.2796 · Cited by 368 · see citing works
Wang, T., Bai, J., Jiang, X., & Nienhaus, G. U. (2012) · ACS Nano · doi:10.1021/nn203892h · Cited by 362 · see citing works
Meng, H., Yang, S., Li, Z., Xia, T., Chen, J., Ji, Z., Zhang, H., Wang, X., Lin, S., Huang, C. Y., et al. (2011) · ACS Nano · doi:10.1021/nn103344k · Cited by 362 · see citing works
New frontiers in nanotechnology for cancer treatment
Alexis, F., Rhee, J., Richie, J. P., Radovic‐Moreno, A. F., Langer, R., & Farokhzad, O. C. (2008) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2007.03.017 · Cited by 359 · see citing works
Self-citationWong, H. L., Bendayan, R., Rauth, A. M., Xue, H. Y., Babakhanian, K., & Wu, X. Y. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.101154 · Cited by 344 · see citing works
Intracellular delivery of nanomaterials: How to catch endosomal escape in the act
Martens, T., Remaut, K., Demeester, J., Smedt, S. C. D., & Braeckmans, K. (2014) · Nano Today · doi:10.1016/j.nantod.2014.04.011 · Cited by 341 · see citing works
Wang, Z., Li, N., Zhao, J. L., White, J. C., Qu, P., & Xing, B. (2012) · Chemical Research in Toxicology · doi:10.1021/tx3002093 · Cited by 338 · see citing works
Temperature: The “Ignored” Factor at the NanoBio Interface
Mahmoudi, M., Abdelmonem, A. M., Behzadi, S., Clement, J. H., Dutz, S., Ejtehadi, M. R., Hartmann, R., Kantner, K., Linne, U., Maffre, P., et al. (2013) · ACS Nano · doi:10.1021/nn305337c · Cited by 334 · see citing works
Self-citationThe bromodomain protein Brd4 insulates chromatin from DNA damage signalling
Floyd, S., Pacold, M. E., Huang, Q., Clarke, S. M., Lam, F. C., Cannell, I. G., Bryson, B. D., Rameseder, J., Lee, M. J., Blake, E. J., et al. (2013) · Nature · doi:10.1038/nature12147 · Cited by 330 · see citing works
Nanoparticle Geometry and Surface Orientation Influence Mode of Cellular Uptake
Gustafson, H. H., Schneider‐Daum, N., Jones, A. T., Huwer, H., Ghandehari, H., & Lehr, C. (2013) · ACS Nano · doi:10.1021/nn304439f · Cited by 327 · see citing works
Surface functionalization of quantum dots for biological applications
Karakoti, A. S., Shukla, R. K., Shanker, R., & Singh, S. (2014) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2014.11.004 · Cited by 319 · see citing works
Personalized protein coronas: a “key” factor at the nanobiointerface
Hajipour, M. J., Laurent, S., Aghaie, A., Rezaee, F., & Mahmoudi, M. (2014) · Biomaterials Science · doi:10.1039/c4bm00131a · Cited by 309 · see citing works
Self-citationAmphotericin B Formulations and Drug Targeting
Torrado, J. J., Espada, R., Ballesteros, M. P., & Torrado, S. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21179 · Cited by 301 · see citing works
Wang, L., Zhang, T., Li, P., Huang, W., Tang, J., Wang, P., Liu, J., Yuan, Q., Bai, R., Li, B., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b02483 · Cited by 291 · see citing works
Li, Y., Chen, X., & Gu, N. (2008) · The Journal of Physical Chemistry B · doi:10.1021/jp8051906 · Cited by 282 · see citing works
Chompoosor, A., Saha, K., Ghosh, P. S., Macarthy, D. J., Miranda, O. R., Zhu, Z., Arcaro, K. F., & Rotello, V. M. (2010) · Small · doi:10.1002/smll.201000463 · Cited by 275 · see citing works
Abid, A. D., Anderson, D. S., Das, G. K., Winkle, L. S. V., & Kennedy, I. M. (2013) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-10-1 · Cited by 271 · see citing works
Polymeric nanoparticle drug delivery technologies for oral delivery applications
Pridgen, E. M., Alexis, F., & Farokhzad, O. C. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.1018175 · Cited by 270 · see citing works
Self-citationSecreted Biomolecules Alter the Biological Identity and Cellular Interactions of Nanoparticles
Albanese, A., Walkey, C., Olsen, J. B., Guo, H., Emili, A., & Chan, W. C. W. (2014) · ACS Nano · doi:10.1021/nn4061012 · Cited by 269 · see citing works
Caveolae: mining little caves for new cancer targets
Carver, L. A., & Schnitzer, J. E. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1146 · Cited by 266 · see citing works
Folate-mediated delivery of macromolecular anticancer therapeutic agents
Lu, Y. J., & Low, P. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.020 · Cited by 266 · see citing works
Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly
Schmid, E. M., Ford, M. G. J., Burtey, A., Praefcke, G. J. K., Peak‐Chew, S., Mills, I. G., Benmerah, A., & McMahon, H. T. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040262 · Cited by 263 · see citing works
Exocytosis of nanoparticles from cells: Role in cellular retention and toxicity
Sakhtianchi, R., Minchin, R. F., Lee, K., Alkilany, A. M., Serpooshan, V., & Mahmoudi, M. (2013) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2013.10.013 · Cited by 262 · see citing works
Self-citationMacropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events
Falcone, S., Cocucci, E., Podini, P., Kirchhausen, T. L., Clementi, E., & Meldolesi, J. (2006) · Journal of Cell Science · doi:10.1242/jcs.03238 · Cited by 257 · see citing works
Personalized disease-specific protein corona influences the therapeutic impact of graphene oxide
Hajipour, M. J., Raheb, J., Akhavan, O., Arjmand, S., Mashinchian, O., Rahman, M., Abdolahad, M., Serpooshan, V., Laurent, S., & Mahmoudi, M. (2015) · Nanoscale · doi:10.1039/c5nr00520e · Cited by 257 · see citing works
Self-citationPark, J. S., Han, T. H., Lee, K. Y., et al. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.07.011 · Cited by 251 · see citing works
Isoforms of caveolin-1 and caveolar structure
Fujimoto, T., Kogo, H., Nomura, R., & Une, T. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.19.3509 · Cited by 251 · see citing works
Brown, D., Gluck, S. L., & Hartwig, J. H. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.4.1637 · Cited by 250 · see citing works
Self-citationMembrane traffic and the cellular uptake of cholera toxin
Lencer, W. I., Hirst, T. R., & Holmes, R. K. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(99)00070-1 · Cited by 246 · see citing works
Sabolić, I., Katsura, T., Verbavatz, J., et al. (1995) · The Journal of Membrane Biology · doi:10.1007/bf00233445 · Cited by 233 · see citing works
Nabiev, I. R., Mitchell, S., Davies, A. M., Williams, Y., Kelleher, D. P., Moore, R., Gun’ko, Y. K., Byrne, S. J., Ракович, Ю. П., Donegan, J. F., et al. (2007) · Nano Letters · doi:10.1021/nl0719832 · Cited by 231 · see citing works
Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes
Chen, J., Hessler, J. A., Putchakayala, K., Panama, B. K., Khan, D. P., Hong, S., Mullen, D. G., DiMaggio, S. C., Som, A., Tew, G. N., et al. (2009) · The Journal of Physical Chemistry B · doi:10.1021/jp9033936 · Cited by 230 · see citing works
Douglas, K. L. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.09.002 · Cited by 226 · see citing works
Time and space resolved uptake study of silicananoparticles by human cells
Shapero, K. S., Fenaroli, F., Lynch, I., Cottell, D. C., Salvati, A. L., & Dawson, K. A. (2010) · Molecular BioSystems · doi:10.1039/c0mb00109k · Cited by 226 · see citing works
Effects of Nanoparticle Charge and Shape Anisotropy on Translocation through Cell Membranes
Nangia, S., & Sureshkumar, R. (2012) · Langmuir · doi:10.1021/la303449d · Cited by 224 · see citing works
When cell biology meets development: endocytic regulation of signaling pathwaysPreprint
Seto, E., Bellen, H. J., & Lloyd, T. E. (2002) · Genes & Development · doi:10.1101/gad.989602 · Cited by 224 · see citing works
Narayan, K., & Subramaniam, S. (2015) · Nature Methods · doi:10.1038/nmeth.3623 · Cited by 224 · see citing works
Evaluation of Nanoparticle Aggregation in Human Blood Serum
Rausch, K., Reuter, A., Fischer, K., & Schmidt, M. (2010) · Biomacromolecules · doi:10.1021/bm100971q · Cited by 223 · see citing works
Multifunctional Lipid/Quantum Dot Hybrid Nanocontainers for Controlled Targeting of Live Cells
Gopalakrishnan, G., Danelon, C., Izewska, P., Prummer, M., Bolinger, P., Geissbühler, I., Demurtas, D., Dubochet, J., & Vogel, H. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200600545 · Cited by 222 · see citing works
Johnston, H. J., Semmler‐Behnke, M., Brown, D. M., Kreyling, W. G., Tran, L., & Stone, V. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.09.015 · Cited by 218 · see citing works
Self-citationKrol, S., Macrez, R., Docagne, F., Defer, G. L., Laurent, S., Rahman, M., Hajipour, M. J., Kehoe, P. G., & Mahmoudi, M. (2012) · Chemical Reviews · doi:10.1021/cr200472g · Cited by 217 · see citing works
Self-citationToxicity of Polyalkylcyanoacrylate Nanoparticles II: Doxorubicin-Loaded Nanoparticles
Couvreur, P., Kante, B., Grislain, L., Roland, M., & Speiser, P. P. (1982) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600710717 · Cited by 217 · see citing works
Mora, R. C., Bonilha, V. L., Marmorstein, A. D., Scherer, P. E., Brown, D., Lisanti, M. P., & Rodriguez-Boulan, E. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25708 · Cited by 216 · see citing works
Self-citationVranic, S., Boggetto, N., Contremoulins, V., Mornet, S., Reinhardt, N., Marano, F., Baeza‐Squiban, A., & Boland, S. (2013) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-10-2 · Cited by 215 · see citing works
Cellular Uptake and Cytotoxicity of Silica Nanotubes
Nan, A., Bai, X., Son, S. J., Lee, S. B., & Ghandehari, H. (2008) · Nano Letters · doi:10.1021/nl0802741 · Cited by 212 · see citing works
Drescher, D., Giesen, C., Traub, H., Panne, U., Kneipp, J., & Jakubowski, N. (2012) · Analytical Chemistry · doi:10.1021/ac302639c · Cited by 210 · see citing works
Gene Transfer by Means of Lipo- and Polyplexes: Role of Clathrin and Caveolae-Mediated Endocytosis
Rejman, J., Conese, M., & Hoekstra, D. (2006) · Journal of Liposome Research · doi:10.1080/08982100600848819 · Cited by 207 · see citing works
Tao, W., Zeng, X., Wu, J., Zhu, X., Yu, X., Zhang, X., Zhang, J., Liu, G., & Mei, L. (2016) · Theranostics · doi:10.7150/thno.14184 · Cited by 204 · see citing works
Self-citationHarnessing Janus Nanoparticles to Create Controllable Pores in Membranes
Alexeev, A., Uspal, W. E., & Balazs, A. C. (2008) · ACS Nano · doi:10.1021/nn8000998 · Cited by 198 · see citing works
Variation of Protein Corona Composition of Gold Nanoparticles Following Plasmonic Heating
Mahmoudi, M., Lohse, S. E., Murphy, C. J., Fathizadeh, A., Montazeri, A., & Suslick, K. S. (2013) · Nano Letters · doi:10.1021/nl403419e · Cited by 194 · see citing works
Self-citationLiu, J., Wang, P., Zhang, X., Wang, L., Wang, D., Gu, Z., Tang, J., Guo, M., Cao, M., Zhou, H., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b00745 · Cited by 192 · see citing works
Nanoparticles of Compacted DNA Transfect Postmitotic Cells
Liu, G., Li, D., Pasumarthy, M. K., Kowalczyk, T. H., Gedeon, C. R., Hyatt, S. L., Payne, J. M., Miller, T. J., Brunovskis, P., Fink, T. L., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305776200 · Cited by 190 · see citing works
Wang, J., Yu, Y., Lu, K., Yang, M. G., Yang, L., Zhou, X., & Sun, Z. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s123596 · Cited by 189 · see citing works
Coping with the inevitable: how cells repair a torn surface membrane
McNeil, P. L., & Terasaki, M. (2001) · Nature Cell Biology · doi:10.1038/35074652 · Cited by 187 · see citing works
Dreaden, E. C., Morton, S. W., Shopsowitz, K. E., Choi, J.-H., Deng, Z. J., Cho, N.-J., & Hammond, P. T. (2014) · ACS Nano · doi:10.1021/nn502861t · Cited by 179 · see citing works
Self-citationBehzadi, S., Serpooshan, V., Sakhtianchi, R., et al. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.09.009 · Cited by 178 · see citing works
Self-citationCorrelative Super-Resolution Microscopy: New Dimensions and New Opportunities
Hauser, M., Wojcik, M., Kim, D., Mahmoudi, M., Li, W., & Xu, K. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00604 · Cited by 177 · see citing works
Self-citationProtein corona: Opportunities and challenges
Zanganeh, S., Spitler, R., Erfanzadeh, M., Alkilany, A. M., & Mahmoudi, M. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.01.005 · Cited by 176 · see citing works
Self-citationEtchable plasmonic nanoparticle probes to image and quantify cellular internalization
Braun, G. B., Friman, T., Pang, H. B., Pallaoro, A., de Mendoza, T. H., Willmore, A.-M. A., Kotamraju, V. R., Mann, A. P., She, Z. G., Sugahara, K. N., et al. (2014) · Nature Materials · doi:10.1038/nmat3982 · Cited by 174 · see citing works
Statistical analysis of nanoparticle dosing in a dynamic cellular system
Summers, H. D., Rees, P. C. T., Holton, M. D., Brown, M. R., Chappell, S. C., Smith, P. J., & Errington, R. J. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.277 · Cited by 172 · see citing works
Sahay, G., Kim, J. O., Kabanov, A. V., & Bronich, T. K. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.101 · Cited by 171 · see citing works
Big Signals from Small Particles: Regulation of Cell Signaling Pathways by Nanoparticles
Rauch, J., Kölch, W., Laurent, S., & Mahmoudi, M. (2013) · Chemical Reviews · doi:10.1021/cr3002627 · Cited by 169 · see citing works
Self-citationde Verdière, A., Dubernet, C., Némati, F., Soma, E., Appel, M., Ferté, J., Bernard, S., Puisieux, F., & Couvreur, P. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.362 · Cited by 168 · see citing works
HER‐2‐Targeted Nanoparticle–Affibody Bioconjugates for Cancer Therapy
Alexis, F., Basto, P. A., Levy‐Nissenbaum, E., Radovic‐Moreno, A. F., Zhang, L., Pridgen, E. M., Wang, A. Z., Marein, S., Westerhof, K., Molnar, L. K., et al. (2008) · ChemMedChem · doi:10.1002/cmdc.200800122 · Cited by 164 · see citing works
Self-citationYanes, R. E., Tarn, D., Hwang, A., Ferris, D. P., Sherman, S. P., Thomas, C. R., Lu, J., Pyle, A. D., Zink, J. I., & Tamanoi, F. (2012) · Small · doi:10.1002/smll.201201811 · Cited by 164 · see citing works
Thermodynamics of Charged Nanoparticle Adsorption on Charge-Neutral Membranes: A Simulation Study
Li, Y., & Gu, N. (2010) · The Journal of Physical Chemistry B · doi:10.1021/jp904550b · Cited by 161 · see citing works
Designing synthetic vesicles that engulf nanoscopic particles
Smith, K. A., Jasnow, D., & Balazs, A. C. (2007) · The Journal of Chemical Physics · doi:10.1063/1.2766953 · Cited by 153 · see citing works
Kattan, J. G., Droz, J., Couvreur, P., Marino, J. P., Boutan-Laroze, A., Rougier, P. R., Brault, P., Vranckx, H., Grognet, J., Morge, X., et al. (1992) · Investigational New Drugs · doi:10.1007/bf00877245 · Cited by 153 · see citing works
Zhu, X. D., Wu, J., Shan, W., et al. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201509183 · Cited by 151 · see citing works
Schöttler, S., Klein, K., Landfester, K., & Mailänder, V. (2016) · Nanoscale · doi:10.1039/c5nr08196c · Cited by 150 · see citing works
Fibronectin Matrix Turnover Occurs through a Caveolin-1–dependent Process
Sottile, J., & Chandler, J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0672 · Cited by 149 · see citing works
Cell “vision”: complementary factor of protein corona in nanotoxicology
Mahmoudi, M., Saeedi-Eslami, S. N., Shokrgozar, M. A., Azadmanesh, K., Hassanlou, M., Kalhor, H. R., Burtéa, C., Rothen‐Rutishauser, B., Laurent, S., Sheibani, S., et al. (2012) · Nanoscale · doi:10.1039/c2nr31185b · Cited by 148 · see citing works
Self-citationCryo-electron tomography of nanoparticle transmigration into liposome
Bihan, O. L., Bonnafous, P., Marak, L., Bickel, T., Trépout, S., Mornet, S., de Haas, F., Talbot, H., Taveau, J., & Lambert, O. (2009) · Journal of Structural Biology · doi:10.1016/j.jsb.2009.07.006 · Cited by 148 · see citing works
Mirshafiee, V., Kim, R., Mahmoudi, M., & Kraft, M. L. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.11.019 · Cited by 148 · see citing works
Self-citationSchäfer, V., von Briesen, H., Andreesen, R., Steffan, A.-M., Royer, C., Tröster, S., Kreuter, J., & Rübsamen-Waigmann, H. (1992) · Pharmaceutical Research · doi:10.1023/a:1015852732512 · Cited by 146 · see citing works
Personalized liposome–protein corona in the blood of breast, gastric and pancreatic cancer patients
Colapicchioni, V., Tilio, M., Digiacomo, L., Gambini, V., Palchetti, S., Marchini, C., Pozzi, D., Occhipinti, S., Amici, A. R. D., & Caracciolo, G. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.09.002 · Cited by 144 · see citing works
Cellular uptake, evolution, and excretion of silica nanoparticles in human cells
Chu, Z., Huang, Y., Tao, Q., & Li, Q. (2011) · Nanoscale · doi:10.1039/c1nr10499c · Cited by 144 · see citing works
Dynamics and mechanisms of quantum dot nanoparticle cellular uptake
Xiao, Y., Forry, S. P., Gao, X., Holbrook, R. D., Telford, W. G., & Tona, A. (2010) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-8-13 · Cited by 141 · see citing works
The Exocytosis of Fluorescent Nanodiamond and Its Use as a Long‐Term Cell Tracker
Fang, C., Vaijayanthimala, V., Cheng, C., et al. (2011) · Small · doi:10.1002/smll.201101233 · Cited by 135 · see citing works
Microscopic Imaging and Spectroscopy with Scattered Light
Boustany, N. N., Boppart, S. A., & Backman, V. (2010) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-061008-124811 · Cited by 131 · see citing works
Advanced nuclear analytical and related techniques for the growing challenges in nanotoxicology
Chen, C., Li, Y., Qu, Y., Chai, Z., & Zhao, Y. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60111k · Cited by 130 · see citing works
Electron Microscopy of Biological Materials at the Nanometer Scale
Kourkoutis, L. F., Plitzko, J. M., & Baumeister, W. P. (2012) · Annual Review of Materials Research · doi:10.1146/annurev-matsci-070511-155004 · Cited by 130 · see citing works
Wilson, S. M., & Bacic, A. (2012) · Nature Protocols · doi:10.1038/nprot.2012.096 · Cited by 129 · see citing works
Budded membrane microdomains as tension regulators
Sens, P., & Turner, M. S. (2006) · Physical Review E · doi:10.1103/physreve.73.031918 · Cited by 124 · see citing works
Deformation and poration of lipid bilayer membranes by cationic nanoparticles
Li, S., & Malmstadt, N. (2013) · Soft Matter · doi:10.1039/c3sm27578g · Cited by 120 · see citing works
Characterization of endocytosis and exocytosis of cationic nanoparticles in airway epithelium cells
Dombu, C. Y., Kroubi, M., Zibouche, R., Matran, R., & Betbeder, D. (2010) · Nanotechnology · doi:10.1088/0957-4484/21/35/355102 · Cited by 120 · see citing works
Fiorentino, I., Gualtieri, R., Barbato, V., Mollo, V., Braun, S., Angrisani, A., Turano, M., Furia, M., Netti, P. A., Guarnieri, D., et al. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.09.017 · Cited by 117 · see citing works
Na, K., Lee, K. H., Lee, D. H., & Bae, Y. H. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.08.012 · Cited by 114 · see citing works
Serda, R. E., Mack, A. A., van de Ven, A. L., et al. (2010) · Small · doi:10.1002/smll.201000727 · Cited by 113 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- [44]de Verdià A Br J Cancer 1997 76 198 9231919 PMC2223924
- [76]Doherty GJ McMahon HT Annu Rev Biochem 2009 78 857 902 19317650
- [156]Rothberg KG Heuser JE Donzell WC Ying YS Glenney JR Anderson RG Cell 1992 68 673 682 1739974
- [253]Chithrani BD Chan WCW Nano Lett 2007 7 1542 1550 17465586
- [256]Chen R Huang G Ke PC Applied Physics Letters 2010 97 093706
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Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A., & Langer, R. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0090-8 · Cited by 7,933 · see citing works
Rodell, C. B., Arlauckas, S. P., Cuccarese, M. F., Garris, C. S., Li, R., Ahmed, M. S., Kohler, R. H., Pittet, M. J., & Weissleder, R. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0236-8 · Cited by 1,099 · see citing works
Mendes, B. B., Conniot, J., Avital, A., Yao, D., Jiang, X., Zhou, X., Sharf-Pauker, N., Xiao, Y., Adir, O., Liang, H., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00104-y · Cited by 719 · see citing works
Rapid single-particle chemical imaging of nanoplastics by SRS microscopy
Qian, N., Gao, X., Lang, X., Deng, H., Bratu, T. M., Chen, Q., Stapleton, P., Yan, B., & Min, W. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300582121 · Cited by 467 · see citing works
Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery
Waheed, S., Li, Z., Zhang, F., Chiarini, A., Armato, U., & Wu, J. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01605-4 · Cited by 259 · see citing works
The effects of PEGylation on LNP based mRNA delivery to the eye
Ryals, R. C., Patel, S., Acosta, C., McKinney, M., Pennesi, M. E., & Sahay, G. (2020) · PLOS ONE · doi:10.1371/journal.pone.0241006 · Cited by 194 · see citing works
Drug Delivery with polymeric nanocarriers-cellular uptake mechanisms
Nelemans, L. C., & Gurevich, L. (2020) · Materials · doi:10.3390/ma13020366 · Cited by 173 · see citing works
Gulino, M., Kim, D., Pané, S., Santos, S. D., & Pêgo, A. P. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00689 · Cited by 159 · see citing works
Rompicherla, S. K. L., Arumugam, K., Bojja, S. L., Kumar, N., & Rao, C. M. (2021) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02096-0 · Cited by 86 · see citing works
Del Amo, L., Cano, A., Ettcheto, M., Souto, E. B., Espina, M., Camins, A., García, M. L., & Sánchez-López, E. (2021) · Applied Sciences · doi:10.3390/app11094305 · Cited by 67 · see citing works
miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases
Xu, J., Zheng, Y., Wang, L., Liu, Y., Wang, X., Li, Y., & Chi, G. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01091-6 · Cited by 55 · see citing works
Quantum Dots as A Theranostic Approach in Alzheimer’s Disease: A Systematic Review
Villalva, M. D., Agarwal, V., Ulanova, M., Sachdev, P. S., & Braidy, N. (2021) · Nanomedicine · doi:10.2217/nnm-2021-0104 · Cited by 53 · see citing works
Imiquimod-gemcitabine nanoparticles harness immune cells to suppress breast cancer
Singh, B., Maharjan, S., Pan, D. C., Zhao, Z., Gao, Y., Zhang, Y. S., & Mitragotri, S. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2021.121302 · Cited by 49 · see citing works
Investigating Immunomodulatory Biomaterials for Preventing the Foreign Body Response
Kim, A., Downer, M. A., Berry, C. E., Valencia, C., Fazilat, A. Z., & Griffin, M. (2023) · Bioengineering · doi:10.3390/bioengineering10121411 · Cited by 38 · see citing works
Nanotechnology in the diagnostic and therapy for Alzheimer's disease
Panghal, A., & Flora, S. J. S. (2024) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2024.130559 · Cited by 31 · see citing works
The Ocular Gene Delivery Landscape
Sahu, B., Chug, I., & Khanna, H. (2021) · Biomolecules · doi:10.3390/biom11081135 · Cited by 28 · see citing works
Relative risk reduction: Misinformative measure in clinical trials and COVID-19 vaccine efficacy
Brown, R. B. (2022) · Dialogues in Health · doi:10.1016/j.dialog.2022.100074 · Cited by 11 · see citing works
“Asextracellular vesicles surround the lipid nanoparticle, synthetic mRNA may be isolated and destroyedbylysosomal degradation enzymes [43].”
Current Perspectives of Nanomaterials in Wastewater Treatment for Sustainable Environment
Dullah, S., Gogoi, R., Bhattacharyya, P. N., Borah, D., Kumari, R., Das, J., & Bora, S. S. (2025) · Advances in Wastewater Research · doi:10.1007/978-981-96-3908-3_17 · Cited by 3 · see citing works
- Authors
- Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M.
- Affiliations
- Brigham and Women's Hospital (US)
- Stanford Cardiovascular Institute (US)
- King Hussein Cancer Center
- University of Jordan (JO)
- Koch Institute for Integrative Cancer Research At MIT (US)
- Harvard University (US)
- Corresponding author
- Alkilany, Alaaldin M.
- Farokhzad, Omid C.
- Mahmoudi, Morteza
- ORCID
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 46
- Issue
- 14
- Pages
- 4218-4244
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- PMC
- PMC5593313
- OpenAlex
- W2624317658
- Cited by
- 2,859
- References
- 263
- Citations by year
- 2026: 331 · 2025: 425 · 2024: 381 · 2023: 346 · 2022: 400 · 2021: 376 · 2020: 281 · 2019: 200 · 2018: 103 · 2017: 13
- FWCI
- 11.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Chemical Society Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (CA151884, EB015419)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Keywords
- nanoparticle uptake, nano-bio interactions, intracellular trafficking, nanoparticle-cell interactions, nanoparticle toxicity, intercellular communication, subcellular localization, nanoparticle tracking analysis, chemical synthesis of nanoparticles
- MeSH terms
- Biochemical Phenomena, Biological Transport, Cell Communication, Humans, Nanoparticles
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