Nernst Limit in Dual-Gated Si-Nanowire FET Sensors
Abstract
Field effect transistors (FETs) are widely used for the label-free detection of analytes in chemical and biological experiments. Here we demonstrate that the apparent sensitivity of a dual-gated silicon nanowire FET to pH can go beyond the Nernst limit of 60 mV/pH at room temperature. This result can be explained by a simple capacitance model including all gates. The consistent and reproducible results build to a great extent on the hysteresis- and leakage-free operation. The dual-gate approach can be used to enhance small signals that are typical for bio- and chemical sensing at the nanoscale.
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The DG ISFET platform effectively breaks through the barrier of Nernst response, showing outstanding sensitivity ranging from 220 mV/pH to 2.25 V/pH.
“In literature, the platform effectively breaks through the barrier of Nernst response, showing outstanding sensitivity ranging from 220 mV/pH to 2.25 V/pH1314.”
From Performance Enhancement of Capacitive-Coupling Dual-gate Ion-Sensitive Field-Effect Transistor in Ultra-Thin-Body (2014) · cites this paper as [13]
The ISFETs with an additional gate, called the DG ISFET, have been first proposed utilizing organic thin-film transistor (TFT) and silicon nanowire field-effect transistor in order to beat the Nernst response.
“In the meantime, the ISFETs with an additional gate, called as the DG ISFET, have been first proposed, utilizing organic thin-film transistor (TFT)12 and silicon nanowire field-effect transistor13, in order to beat the Nernst response”
From Performance Enhancement of Capacitive-Coupling Dual-gate Ion-Sensitive Field-Effect Transistor in Ultra-Thin-Body (2014) · cites this paper as [13]
The EFN-enhanced sensitivity is not due to additional biasing as argued for the dual-gated SiNW.
“It should be noted that the EFN-enhanced sensitivity is not due to additional biasing as was argued for the dual-gated SiNW.35”
From Specific and label-free femtomolar biomarker detection with an electrostatically formed nanowire biosensor (2013) · cites this paper as [35]
Cites
Development of an Ion-Sensitive Solid-State Device for Neurophysiological Measurements
Bergveld, P. (1970) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.1970.4502688 · Cited by 2,134 · see citing works
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Sensor systems for bioprocess monitoring
Biechele, P., Busse, C., Solle, D., Scheper, T., & Reardon, K. (2015) · Engineering in Life Sciences · doi:10.1002/elsc.201500014 · Cited by 224 · see citing works
Jang, H.-J., & Cho, W.-J. (2014) · Scientific Reports · doi:10.1038/srep05284 · Cited by 103 · see citing works
Shalev, G., Landman, G., Amit, I., Rosenwaks, Y., & Levy, I. (2013) · NPG Asia Materials · doi:10.1038/am.2012.75 · Cited by 61 · see citing works
- Authors
- Knopfmacher, O., Tarasov, A., Fu, W., Wipf, M., Niesen, B., Calame, M., & Schönenberger, C.
- Affiliations
- University of Basel (CH)
- Department of Physics, University of Basel, Klingelbergstrasse 82, CH-4056 Basel, Switzerland
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-05-25
- Volume
- 10
- Issue
- 6
- Pages
- 2268-2274
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1967539302
- Cited by
- 353
- References
- 1
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 16 · 2023: 14 · 2022: 17 · 2021: 26 · 2020: 27 · 2019: 25 · 2018: 23 · 2017: 27 · 2016: 27 · 2015: 22 · 2014: 34 · 2013: 32 · 2012: 22
- FWCI
- 14.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanowire Synthesis and Applications
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advancements in Semiconductor Devices and Circuit Design
- Keywords
- silicon nanowire transistors, pH sensing, label-free detection, capacitance model, signal amplification, hysteresis-free operation, chemical and biological sensors
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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