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Toward Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators

Open access
Lee, Jungchul, Shen, Wenjiang, Payer, Kris, Burg, Thomas P., Manalis, Scott R.·2010·Nano Letters

Abstract

Using suspended nanochannel resonators (SNRs), we demonstrate measurements of mass in solution with a resolution of 27 ag in a 1 kHz bandwidth, which represents a 100-fold improvement over existing suspended microchannel resonators and, to our knowledge, is the most precise mass measurement in liquid today. The SNR consists of a cantilever that is 50 microm long, 10 microm wide, and 1.3 microm thick, with an embedded nanochannel that is 2 microm wide and 700 nm tall. The SNR has a resonance frequency near 630 kHz and exhibits a quality factor of approximately 8000 when dry and when filled with water. In addition, we introduce a new method that uses centrifugal force caused by vibration of the cantilever to trap particles at the free end. This approach eliminates the intrinsic position dependent error of the SNR and also improves the mass resolution by increasing the averaging time for each particle.

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Metadata

Authors
Lee, J., Shen, W., Payer, K., Burg, T. P., & Manalis, S. R.
Venue
Nano Letters
Published
2010-06-08
Volume
10
Issue
7
Pages
2537-2542
ISSN
  • 1530-6984 (ISSN-L)
  • 1530-6992
OpenAlex
W1978597639
Cited by
181
References
2
FWCI
7.83
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Toward Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators. https://app.cochat.ai/papers/10.1021/nl101107u
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Lee, J., Shen, W., Payer, K., Burg, T. P., & Manalis, S. R. (2010). Toward Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators. Nano Letters. https://doi.org/10.1021/nl101107u

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.