The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A DNA−Silver Nanocluster Probe That Fluoresces upon Hybridization
Abstract
DNA-templated silver nanoclusters (DNA/Ag NCs) are an emerging set of fluorophores that are smaller than semiconductor quantum dots and can have better photostability and brightness than commonly used organic dyes. Here we find the red fluorescence of DNA/Ag NCs can be enhanced 500-fold when placed in proximity to guanine-rich DNA sequences. On the basis of this new phenomenon, we have designed a DNA detection probe (NanoCluster Beacon, NCB) that "lights up" upon target binding. Since NCBs do not rely on Forster energy transfer for quenching, they can easily reach high (>100) signal-to-background ratios (S/B ratios) upon target binding. Here, in a separation-free assay, we demonstrate NCB detection of an influenza target with a S/B ratio of 175, a factor of 5 better than a conventional molecular beacon probe. Since the observed fluorescence enhancement is caused by intrinsic nucleobases, our detection technique is simple, inexpensive, and compatible with commercial DNA synthesizers.
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Citations
Cites
Imaging individual mRNA molecules using multiple singly labeled probes
Raj, A., van den Bogaard, P., Rifkin, S. A., van Oudenaarden, A., & Tyagi, S. (2008) · Nature Methods · doi:10.1038/nmeth.1253 · Cited by 2,028
Cited by
Optical aptasensors for quantitative detection of small biomolecules: A review
Feng, C., Dai, S., & Wang, L. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.03.014 · Cited by 300
Use of Fluorescent DNA-Templated Gold/Silver Nanoclusters for the Detection of Sulfide Ions
Chen, W.-Y., Lan, G.-Y., & Chang, H.-T. (2011) · Analytical Chemistry · doi:10.1021/ac202162u · Cited by 283
Kan, X., Wang, J., Li, Y., Li, D., Li, F., Huang, C., & Liu, P. (2026) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2025.115397 · Cited by 3
Metadata
- Authors
- Yeh, H.-C., Sharma, J., Han, J. J., Martinez, J. S., & Werner, J. H.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-07-19
- Volume
- 10
- Issue
- 8
- Pages
- 3106-3110
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2034412692
- Cited by
- 654
- References
- 1
- FWCI
- 15.48
- Type
- journal article
- Language
- en
- Open access
- closed
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