The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Plasmon-Enhanced Colorimetric ELISA with Single Molecule Sensitivity
Abstract
Robust but ultrasensitive biosensors with a capability of detecting low abundance biomarkers could revolutionize clinical diagnostics and enable early detection of cancer, neurological diseases, and infections. We utilized a combination of localized surface plasmon resonance (LSPR) refractive index sensing and the well-known enzyme-linked immunosorbent assay to develop a simple colorimetric biosensing methodology with single molecule sensitivity. The technique is based on spectral imaging of a large number of isolated gold nanoparticles. Each particle binds a variable number of horseradish peroxidase (HRP) enzyme molecules that catalyze a localized precipitation reaction at the particle surface. The enzymatic reaction dramatically amplifies the shift of the LSPR scattering maximum, λ(max), and makes it possible to detect the presence of only one or a few HRP molecules per particle.
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Weighing of biomolecules, single cells and single nanoparticles in fluid
Burg, T. P., Godin, M., Knudsen, S. M., Shen, W., Carlson, G., Foster, J. S., Babcock, K., & Manalis, S. R. (2007) · Nature · doi:10.1038/nature05741 · Cited by 1,213
Cited by
Plasmonic ELISA for the ultrasensitive detection of disease biomarkers with the naked eye
de la Rica, R., & Stevens, M. M. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.186 · Cited by 873
Zijlstra, P., Paulo, P. M. R., & Orrit, M. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.51 · Cited by 788
LSPR Chip for Parallel, Rapid, and Sensitive Detection of Cancer Markers in Serum
Aćimović, S. S., Ortega, M. A., Sanz, V., Berthelot, J., Garcia-Cordero, J. L., Renger, J., Maerkl, S. J., Kreuzer, M. P., & Quidant, R. (2014) · Nano Letters · doi:10.1021/nl500574n · Cited by 310
Metadata
- Authors
- Chen, S., Svedendahl, M., Van Duyne, R. P., & Käll, M.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-03-23
- Volume
- 11
- Issue
- 4
- Pages
- 1826-1830
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1997946708
- Cited by
- 186
- References
- 1
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- closed
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