The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Optical detection of single non-absorbing molecules using the surface plasmon resonance of a gold nanorod
Open accessAbstract
Existing methods for the optical detection of single molecules require the molecules to absorb light to produce fluorescence or direct absorption signals. This limits the range of species that can be detected, because most molecules are purely refractive. Metal nanoparticles or dielectric resonators can be used to detect non-absorbing molecules because local changes in the refractive index produce a resonance shift. However, current approaches only detect single molecules when the resonance shift is amplified by a highly polarizable label or by a localized precipitation reaction on the surface of a nanoparticle. Without such amplification, single-molecule events can only be identified in a statistical way. Here, we report the plasmonic detection of single molecules in real time without the need for labelling or amplification. Our sensor consists of a single gold nanorod coated with biotin receptors, and the binding of single proteins is detected by monitoring the plasmon resonance of the nanorod with a sensitive photothermal assay. The sensitivity of our device is ∼700 times higher than state-of-the-art plasmon sensors and is intrinsically limited by spectral diffusion of the surface plasmon resonance.
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Cites
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Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)
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Biosensing with plasmonic nanosensors
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Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method
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Localized Surface Plasmon Resonance Sensors
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Surface-Enhanced Raman Spectroscopy
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A molecular ruler based on plasmon coupling of single gold and silver nanoparticles
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種結晶を媒介とした成長法を用いた金ナノロッド(NR)の調製と成長メカニズム
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Cited by
Plasmonic Biosensing: Focus Review
Mejía-Salazar, J. R., & Oliveira, O. N. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00359 · Cited by 544
Non-plasmonic nanoantennas for surface enhanced spectroscopies with ultra-low heat conversion
Caldarola, M., Albella, P., Cortés, E., Rahmani, M., Roschuk, T., Grinblat, G., Oulton, R. F., Bragas, A. V., & Maier, S. A. (2015) · Nature Communications · doi:10.1038/ncomms8915 · Cited by 520
Single-Molecule Plasmon Sensing: Current Status and Future Prospects
Taylor, A. B., & Zijlstra, P. (2017) · ACS Sensors · doi:10.1021/acssensors.7b00382 · Cited by 366
Self-citationPiliarik, M., & Sandoghdar, V. (2014) · Nature Communications · doi:10.1038/ncomms5495 · Cited by 332
Yoo, D., Gurunatha, K. L., Choi, H.-K., Mohr, D. A., Ertsgaard, C. T., Gordon, R., & Oh, S.-H. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b00732 · Cited by 173
Metadata
- Authors
- Zijlstra, P., Paulo, P. M. R., & Orrit, M.
- Venue
- Nature Nanotechnology
- Published
- 2012-04-15
- Volume
- 7
- Issue
- 6
- Pages
- 379-382
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2051276349
- Cited by
- 788
- References
- 33
- FWCI
- 32.61
- Type
- journal article
- Language
- en
- Open access
- green
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