The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Minimizing Oxidation and Stable Nanoscale Dispersion Improves the Biocompatibility of Graphene in the Lung
Open accessAbstract
To facilitate the proposed use of graphene and its derivative graphene oxide (GO) in widespread applications, we explored strategies that improve the biocompatibility of graphene nanomaterials in the lung. In particular, solutions of aggregated graphene, Pluronic dispersed graphene, and GO were administered directly into the lungs of mice. The introduction of GO resulted in severe and persistent lung injury. Furthermore, in cells GO increased the rate of mitochondrial respiration and the generation of reactive oxygen species, activating inflammatory and apoptotic pathways. In contrast, this toxicity was significantly reduced in the case of pristine graphene after liquid phase exfoliation and was further minimized when the unoxidized graphene was well-dispersed with the block copolymer Pluronic. Our results demonstrate that the covalent oxidation of graphene is a major contributor to its pulmonary toxicity and suggest that dispersion of pristine graphene in Pluronic provides a pathway for the safe handling and potential biomedical application of two-dimensional carbon nanomaterials.
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Cites
Graphene: Status and Prospects
Geim, A. K. (2009) · Science · doi:10.1126/science.1158877 · Cited by 13,942
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003428107 · Cited by 1,742
Self-citationHanson, G. T., Aggeler, R., Oglesbee, D., Cannon, M., Capaldi, R. A., Tsien, R. Y., & Remington, S. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312846200 · Cited by 988
Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators
Dooley, C. T., Dore, T. M., Hanson, G. T., Jackson, W. C., Remington, S. J., & Tsien, R. Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312847200 · Cited by 776
Cited by
Nano-graphene in biomedicine: theranostic applications
Yang, K., Feng, L., Shi, X., & Liu, Z. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35342c · Cited by 1,634
Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
Self-citationThe role of macrophages in the resolution of inflammation
Watanabe, S., Alexander, M., Misharin, A. V., & Budinger, G. R. S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124615 · Cited by 925
Self-citationNanotoxicity of Graphene and Graphene Oxide
Seabra, A. B., Paula, A. J., de Lima, R., Alves, O. L., & Durán, N. (2014) · Chemical Research in Toxicology · doi:10.1021/tx400385x · Cited by 893
Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms
Ou, L., Song, B., Liang, H., Liu, J., Feng, X., Deng, B., Sun, T., & Shao, L. (2016) · Particle and Fibre Toxicology · doi:10.1186/s12989-016-0168-y · Cited by 803
Metadata
- Authors
- Duch, M. C., Budinger, G. R. S., Liang, Y. T., Soberanes, S., Urich, D., Chiarella, S. E., Campochiaro, L. A., Gonzalez, A., Chandel, N. S., Hersam, M. C., & Mutlu, G. M.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-10-27
- Volume
- 11
- Issue
- 12
- Pages
- 5201-5207
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2081705834
- Cited by
- 546
- References
- 4
- FWCI
- 19.69
- Type
- journal article
- Language
- en
- Open access
- green
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