The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Role of Nanoparticle Geometry in Endocytosis: Laying Down to Stand Up
Abstract
Nanoparticles (NPs) hold great promises for targeted disease diagnosis and therapy. Despite considerable progress in biomimetic design of NP-bioconjugates, the roles of NP size and shape in endocytosis are still not fully understood. Using an efficient coarse-grained molecular dynamics (CGMD) model, we simulate receptor-mediated endocytosis of NPs of various sizes and shapes. Our simulations demonstrate that both NP size and shape modulate the kinetics of endocytosis. For spherical NPs, there exists an optimal size at which endocytosis takes the shortest time. For a spherocylindrical NP with the initial upright docking position on the membrane plane, endocytosis proceeds through a laying-down-then-standing-up sequence. A free energy analysis reveals that NP size primarily determines whether endocytosis can complete, while NP shape breaks the symmetry of curvature energy landscape and hence dictates the endocytic pathway and the angle of entry. The findings shed light on the rational design of NP-based diagnostic and therapeutic agents with improved cellular targeting.
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Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
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The effect of particle design on cellular internalization pathways
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Nanoparticle-mediated cellular response is size-dependent
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Self-citationSize‐Dependent Endocytosis of Nanoparticles
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Self-citation
Cited by
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Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Self-citationPhysical Principles of Nanoparticle Cellular Endocytosis
Zhang, S., Gao, H., & Bao, G. (2015) · ACS Nano · doi:10.1021/acsnano.5b03184 · Cited by 1,103
Self-citationShape and Orientation Matter for the Cellular Uptake of Nonspherical Particles
Dasgupta, S., Auth, T., & Gompper, G. (2014) · Nano Letters · doi:10.1021/nl403949h · Cited by 531
Entry of nanoparticles into cells: the importance of nanoparticle properties
Zhao, J., & Stenzel, M. H. (2018) · Polymer Chemistry · doi:10.1039/c7py01603d · Cited by 391
Li, J., Shi, K., Sabet, Z. F., Fu, W., Zhou, H., Xu, S., Liu, T., You, M., Cao, M., Xu, M., et al. (2019) · Science Advances · doi:10.1126/sciadv.aax0937 · Cited by 134
Metadata
- Authors
- Huang, C., Zhang, Y., Yuan, H., Gao, H., & Zhang, S.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-08-28
- Volume
- 13
- Issue
- 9
- Pages
- 4546-4550
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2319217905
- Cited by
- 257
- References
- 34
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
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