The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
High Resolution Live Cell Raman Imaging Using Subcellular Organelle-Targeting SERS-Sensitive Gold Nanoparticles with Highly Narrow Intra-Nanogap
Open accessAbstract
We report a method to achieve high speed and high resolution live cell Raman images using small spherical gold nanoparticles with highly narrow intra-nanogap structures responding to NIR excitation (785 nm) and high-speed confocal Raman microscopy. The three different Raman-active molecules placed in the narrow intra-nanogap showed a strong and uniform Raman intensity in solution even under transient exposure time (10 ms) and low input power of incident laser (200 μW), which lead to obtain high-resolution single cell image within 30 s without inducing significant cell damage. The high resolution Raman image showed the distributions of gold nanoparticles for their targeted sites such as cytoplasm, mitochondria, or nucleus. The high speed Raman-based live cell imaging allowed us to monitor rapidly changing cell morphologies during cell death induced by the addition of highly toxic KCN solution to cells. These results strongly suggest that the use of SERS-active nanoparticle can greatly improve the current temporal resolution and image quality of Raman-based cell images enough to obtain the detailed cell dynamics and/or the responses of cells to potential drug molecules.
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Cites
Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells
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Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy
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Self-citationStudying single living cells and chromosomes by confocal Raman microspectroscopy
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Kang, B., Mackey, M. A., & El-Sayed, M. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja9102698 · Cited by 674
In Vivo Molecular Probing of Cellular Compartments with Gold Nanoparticles and Nanoaggregates
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Surface-Enhanced Raman Spectroscopy (SERS) for Sub-Micromolar Detection of DNA/RNA Mononucleotides
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Raman and SERS microscopy for molecular imaging of live cells
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Imaging of EdU, an Alkyne-Tagged Cell Proliferation Probe, by Raman Microscopy
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Cited by
Raman spectroscopy: techniques and applications in the life sciences
Shipp, D. W., Sinjab, F., & Notingher, I. (2017) · Advances in Optics and Photonics · doi:10.1364/aop.9.000315 · Cited by 396
Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA
Kobayashi-Kirschvink, K. J., Comiter, C. S., Gaddam, S., Joren, T., Grody, E. I., Ounadjela, J. R., Zhang, K., Ge, B., Kang, J. W., Xavier, R. J., et al. (2024) · Nature Biotechnology · doi:10.1038/s41587-023-02082-2 · Cited by 93
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Ionophore-Based SERS Nanosensors for Selective Electrolyte Detection and Intracellular Mapping
Zhang, L., Tang, Z., Coronel-Zegarra, A., Merk, V., Zhu, X., & Wang, R. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c05634 · Cited by 1
Nishitsuji, R., Kawasaki, D., Nakashima, T., Sueyoshi, K., Hisamoto, H., & Endo, T. (2026) · Soft Computing · doi:10.1007/s00500-026-11387-8
Metadata
- Authors
- Kang, J. W., So, P. T. C., Dasari, R. R., & Lim, D.-K.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-02-11
- Volume
- 15
- Issue
- 3
- Pages
- 1766-1772
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2319288524
- Cited by
- 299
- References
- 22
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- green
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