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Polyvalent DNA Nanoparticle Conjugates Stabilize Nucleic Acids
Open accessAbstract
Polyvalent oligonucleotide gold nanoparticle conjugates have unique fundamental properties including distance-dependent plasmon coupling, enhanced binding affinity, and the ability to enter cells and resist enzymatic degradation. Stability in the presence of enzymes is a key consideration for therapeutic uses; however the manner and mechanism by which such nanoparticles are able to resist enzymatic degradation is unknown. Here, we quantify the enhanced stability of polyvalent gold oligonucleotide nanoparticle conjugates with respect to enzyme-catalyzed hydrolysis of DNA and present evidence that the negatively charged surfaces of the nanoparticles and resultant high local salt concentrations are responsible for enhanced stability.
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Citations
Cited by
Ray, P. C. (2010) · Chemical Reviews · doi:10.1021/cr900335q · Cited by 773
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Jensen, S. A., Day, E. S., Ko, C. H., Hurley, L. A., Luciano, J. P., Kouri, F. M., Merkel, T. J., Luthi, A. J., Patel, P. C., Cutler, J. I., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006839 · Cited by 592
Self-citationA Review on the Synthesis and Functionalization of Gold Nanoparticles as a Drug Delivery Vehicle
Amina, S. J., & Guo, B. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s279094 · Cited by 561
Gold Nanoparticles for Nucleic Acid Delivery
Ding, Y., Jiang, Z., Saha, K., Kim, C. S., Kim, S. T., Landis, R. F., & Rotello, V. M. (2014) · Molecular Therapy · doi:10.1038/mt.2014.30 · Cited by 521
The landscape of nanoparticle-based siRNA delivery and therapeutic development
Moazzam, M., Zhang, M., Hussain, A., Yu, X., Huang, J., & Huang, Y. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.01.005 · Cited by 230
Metadata
- Authors
- Seferos, D. S., Prigodich, A. E., Giljohann, D. A., Patel, P. C., & Mirkin, C. A.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-01-14
- Volume
- 9
- Issue
- 1
- Pages
- 308-311
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2003451349
- Cited by
- 551
- References
- 0
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Seferos, D. S., Prigodich, A. E., Giljohann, D. A., Patel, P. C., & Mirkin, C. A. (2009). Polyvalent DNA Nanoparticle Conjugates Stabilize Nucleic Acids. Nano Letters. https://doi.org/10.1021/nl802958f
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