The DOI matches its Crossref record.
Polyvalent DNA Nanoparticle Conjugates Stabilize Nucleic Acids
Open accessAbstract
Polyvalent oligonucleotide gold nanoparticle conjugates have unique fundamental properties including distance-dependent plasmon coupling, enhanced binding affinity, and the ability to enter cells and resist enzymatic degradation. Stability in the presence of enzymes is a key consideration for therapeutic uses; however the manner and mechanism by which such nanoparticles are able to resist enzymatic degradation is unknown. Here, we quantify the enhanced stability of polyvalent gold oligonucleotide nanoparticle conjugates with respect to enzyme-catalyzed hydrolysis of DNA and present evidence that the negatively charged surfaces of the nanoparticles and resultant high local salt concentrations are responsible for enhanced stability.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Gold Nanoparticles for Biology and Medicine
Giljohann, D. A., Seferos, D. S., Daniel, W. L., Massich, M. D., Patel, P. C., & Mirkin, C. A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200904359 · Cited by 2,356
Self-citationCutler, J. I., Auyeung, E., & Mirkin, C. A. (2012) · Journal of the American Chemical Society · doi:10.1021/ja209351u · Cited by 1,119
Self-citationRay, P. C. (2010) · Chemical Reviews · doi:10.1021/cr900335q · Cited by 773
Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma
Jensen, S. A., Day, E. S., Ko, C. H., Hurley, L. A., Luciano, J. P., Kouri, F. M., Merkel, T. J., Luthi, A. J., Patel, P. C., Cutler, J. I., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006839 · Cited by 592
Self-citationA Review on the Synthesis and Functionalization of Gold Nanoparticles as a Drug Delivery Vehicle
Amina, S. J., & Guo, B. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s279094 · Cited by 561
Gold Nanoparticles for Nucleic Acid Delivery
Ding, Y., Jiang, Z., Saha, K., Kim, C. S., Kim, S. T., Landis, R. F., & Rotello, V. M. (2014) · Molecular Therapy · doi:10.1038/mt.2014.30 · Cited by 521
A DNAzyme-Gold Nanoparticle Probe for Uranyl Ion in Living Cells
Wu, P., Hwang, K., Lan, T., & Lu, Y. (2013) · Journal of the American Chemical Society · doi:10.1021/ja400150v · Cited by 428
Adsorption of DNA onto gold nanoparticles and graphene oxide: surface science and applications
Liu, J. (2012) · Physical Chemistry Chemical Physics · doi:10.1039/c2cp41186e · Cited by 408
Patel, P. C., Giljohann, D. A., Daniel, W. L., Zheng, D., Prigodich, A. E., & Mirkin, C. A. (2010) · Bioconjugate Chemistry · doi:10.1021/bc1002423 · Cited by 366
Self-citationAmplification-free CRISPR/Cas detection technology: challenges, strategies, and perspectives
Li, H., Xie, Y., Chen, F., Bai, H., Xiu, L., Zhou, X., Guo, X., Hu, Q., & Yin, K. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00594h · Cited by 346
Multiplexed Nanoflares: mRNA Detection in Live Cells
Prigodich, A. E., Randeria, P. S., Briley, W. E., Kim, N. J., Daniel, W. L., Giljohann, D. A., & Mirkin, C. A. (2012) · Analytical Chemistry · doi:10.1021/ac202648w · Cited by 285
Self-citationThe landscape of nanoparticle-based siRNA delivery and therapeutic development
Moazzam, M., Zhang, M., Hussain, A., Yu, X., Huang, J., & Huang, Y. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.01.005 · Cited by 230
An intestinal Trojan horse for gene delivery
Peng, H., Wang, C., Xu, X., Yu, C., & Wang, Q. (2015) · Nanoscale · doi:10.1039/c4nr06377e · Cited by 66
Liu, J., Guo, L., Mi, Z., Liu, Z., Rong, P., & Zhou, W. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.06.030 · Cited by 40
Metadata
- Authors
- Seferos, D. S., Prigodich, A. E., Giljohann, D. A., Patel, P. C., & Mirkin, C. A.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-01-14
- Volume
- 9
- Issue
- 1
- Pages
- 308-311
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2003451349
- Cited by
- 551
- References
- 0
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
