The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Uptake and Intracellular Fate of Disulfide-Bonded Polymer Hydrogel Capsules for Doxorubicin Delivery to Colorectal Cancer Cells
Abstract
Understanding the interactions between drug carriers and cells is of importance to enhance the delivery of therapeutics. The release of therapeutics into different intracellular environments, such as the lysosomes or the cell cytoplasm, will impact their pharmacological activity. Herein, we investigate the intracellular fate of layer-by-layer (LbL)-assembled, submicrometer-sized polymer hydrogel capsules in a human colon cancer derived cell line, LIM1899. The cellular uptake of the disulfide-stabilized poly(methacrylic acid) (PMA(SH)) capsules by colon cancer cells is a time-dependent process. Confocal laser scanning microscopy and transmission electron microscopy reveal that the internalized capsules are deformed in membrane-enclosed compartments, which further mature to late endosomes or lysosomes. We further demonstrate the utility of these redox-responsive PMA(SH) capsules for the delivery of doxorubicin (DOX) to colon cancer cells. The DOX-loaded PMA(SH) capsules demonstrate a 5000-fold enhanced cytotoxicity in cell viability studies compared to free DOX.
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Cites
The effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918
The Rab5 effector EEA1 is a core component of endosome docking
Christoforidis, S., McBride, H. M., Burgoyne, R. D., & Zerial, M. (1999) · Nature · doi:10.1038/17618 · Cited by 854
Cited by
Cheng, R., Feng, F., Meng, F., Deng, C., Feijen, J., & Zhong, Z. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.01.030 · Cited by 1,360
Fleige, E., Quadir, M. A., & Haag, R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.020 · Cited by 1,111
Polymeric multilayer capsules for drug delivery
De Koker, S., Hoogenboom, R., & De Geest, B. G. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15296g · Cited by 383
Raza, A., Rasheed, T., Nabeel, F., Hayat, U., Bilal, M., & Iqbal, H. M. N. (2019) · Molecules · doi:10.3390/molecules24061117 · Cited by 367
Stimuli-Responsive Nanomaterials for Application in Antitumor Therapy and Drug Delivery
Pham, S. H., Choi, Y., & Choi, J. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070630 · Cited by 248
Metadata
- Authors
- Yan, Y., Johnston, A. P. R., Dodds, S. J., Kamphuis, M. M. J., Ferguson, C., Parton, R. G., Nice, E. C., Heath, J. K., & Caruso, F.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-04-26
- Volume
- 4
- Issue
- 5
- Pages
- 2928-2936
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2043120353
- Cited by
- 161
- References
- 2
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Uptake and Intracellular Fate of Disulfide-Bonded Polymer Hydrogel Capsules for Doxorubicin Delivery to Colorectal Cancer Cells. https://app.cochat.ai/papers/10.1021/nn100173h
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- Yan, Y., Johnston, A. P. R., Dodds, S. J., Kamphuis, M. M. J., Ferguson, C., Parton, R. G., Nice, E. C., Heath, J. K., & Caruso, F. (2010). Uptake and Intracellular Fate of Disulfide-Bonded Polymer Hydrogel Capsules for Doxorubicin Delivery to Colorectal Cancer Cells. ACS Nano. https://doi.org/10.1021/nn100173h
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