Stimuli-Responsive Nanomaterials for Application in Antitumor Therapy and Drug Delivery
Open accessAbstract
The new era of nanotechnology has produced advanced nanomaterials applicable to various fields of medicine, including diagnostic bio-imaging, chemotherapy, targeted drug delivery, and biosensors. Various materials are formed into nanoparticles, such as gold nanomaterials, carbon quantum dots, and liposomes. The nanomaterials have been functionalized and widely used because they are biocompatible and easy to design and prepare. This review mainly focuses on nanomaterials responsive to the external stimuli used in drug-delivery systems. To overcome the drawbacks of conventional therapeutics to a tumor, the dual- and multi-responsive behaviors of nanoparticles have been harnessed to improve efficiency from a drug delivery point of view. Issues and future research related to these nanomaterial-based stimuli sensitivities and the scope of stimuli-responsive systems for nanomedicine applications are discussed.
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High-intensity exogenous electric fields have the ability to directly affect the permeability of cellular membranes, which can be employed as a stimulant for drug administration.
“High-intensity exogenous electric fields have the ability to directly affect the permeability of cellular membranes, which can be employed as a stimulant for drug administration.178”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [178]
Ultrasound has become a common external trigger approach for cancer treatment.
“As a result, it has become a common external trigger approach for cancer treatment.177,178”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [178]
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References 107 · Cited by 248
- Authors
- Pham, S. H., Choi, Y., & Choi, J.
- Affiliations
- Chung-Ang University (KR)
- Corresponding author
- Choi, Jonghoon
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2020-07-04
- Volume
- 12
- Issue
- 7
- Pages
- 630
- ISSN
- 1999-4923 (ISSN-L)
- PMC
- PMC7408499
- OpenAlex
- W3040161911
- Cited by
- 248
- References
- 107
- Citations by year
- 2026: 45 · 2025: 59 · 2024: 42 · 2023: 42 · 2022: 36 · 2021: 23 · 2020: 1
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Pharmaceutics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation of Korea (2017M3A7B8061942 and 2019R1A2C1006018)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- stimuli-responsive nanomaterials, cancer therapy, targeted drug delivery, nanoparticles, gold nanomaterials, carbon quantum dots, liposomes, nanomedicine
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