The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Endo- and Exocytosis of Zwitterionic Quantum Dot Nanoparticles by Live HeLa Cells
Abstract
Uptake and intracellular transport of D-penicillamine coated quantum dots (DPA-QDs) of 4 nm radius by live HeLa cells have been investigated systematically by spinning disk and 4Pi confocal microscopies. Unlike larger nanoparticles, these small DPA-QDs were observed to accumulate at the plasma membrane prior to internalization, and the uptake efficiency scaled nonlinearly with the nanoparticle concentration. Both observations indicate that a critical threshold density has to be exceeded for triggering the internalization process. By using specific inhibitors, we showed that DPA-QDs were predominantly internalized by clathrin-mediated endocytosis and to a smaller extent by macropinocytosis. Clusters of DPA-QDs were found in endosomes, which were actively transported along microtubules toward the perinuclear region. Later on, a significant fraction of endocytosed DPA-QDs were found in lysosomes, while others were actively transported to the cell periphery and exocytosed with a half-life of 21 min.
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Snakes, shapes, and gradient vector flow
Xu, C., & Prince, J. L. (1998) · IEEE Transactions on Image Processing · doi:10.1109/83.661186 · Cited by 4,001
The effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918
Harush-Frenkel, O., Rozentur, E., Benita, S., & Altschuler, Y. (2008) · Biomacromolecules · doi:10.1021/bm700535p · Cited by 405
Cited by
The Effect of Nanoparticle Size on In Vivo Pharmacokinetics and Cellular Interaction
Hoshyar, N., Gray, S., Han, H., & Bao, G. (2016) · Nanomedicine · doi:10.2217/nnm.16.5 · Cited by 1,990
Engineered nanoparticles interacting with cells: size matters
Shang, L., Nienhaus, K., & Nienhaus, G. U. (2014) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-12-5 · Cited by 1,316
Self-citationWang, F., Wang, Y.-C., Dou, S., Xiong, M.-H., Sun, T.-M., & Wang, J. (2011) · ACS Nano · doi:10.1021/nn200007z · Cited by 813
Hühn, D., Kantner, K., Geidel, C., Brandholt, S., De Cock, I., Soenen, S. J. H., Rivera_Gil, P., Montenegro, J.-M., Braeckmans, K., Müllen, K., et al. (2013) · ACS Nano · doi:10.1021/nn3059295 · Cited by 580
Self-citationQuantum dots as a platform for nanoparticle drug delivery vehicle design
Probst, C. E., Zrazhevskiy, P., Bagalkot, V., & Gao, X. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.036 · Cited by 466
Metadata
- Authors
- Jiang, X., Röcker, C., Hafner, M., Brandholt, S., Dörlich, R. M., & Nienhaus, G. U.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-10-28
- Volume
- 4
- Issue
- 11
- Pages
- 6787-6797
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1999546585
- Cited by
- 299
- References
- 3
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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