The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
DNA Cleavage System of Nanosized Graphene Oxide Sheets and Copper Ions
Abstract
The exploration of efficient DNA intercalative agents (intercalators) is essential for understanding DNA scission, repair, and signal transduction. In this work, we explored systematically the graphene oxide (GO) interaction with DNA molecules using fluorescence spectroscopic (FL) and circular dichroism (CD) studies, gel electrophoresis, and DNA thermal denaturation. We demonstrated that the GO nanosheets could intercalate efficiently into DNA molecules. Significantly, we illustrated that the scission of DNA by GO sheets combining with copper ions could take place pronouncedly. The scission of DNA by the GO/Cu(2+) system is critically dependent on the concentrations of GO and Cu(2+) and their ratio. DNA cleavage ability exhibited by the GO with several other metal ions and the fact that GO/Cu(2+)-cleaved DNA fragments can be partially relegated suggest that the mechanism of DNA cleavage by the GO/metal ion system is oxidative and hydrolytic. The result reveals that the GO/Cu(2+) could be used as a DNA cleaving system that should find many practical applications in biotechnology and as therapeutic agents.
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Reduction of graphene oxide via l -ascorbic acid
Zhang, J., Yang, H., Shen, G., Cheng, P., Zhang, J., & Guo, S. (2010) · Chem. Commun. · doi:10.1039/b917705a · Cited by 2,344
Self-citationPogozelski, W. K., & Tullius, T. D. (1998) · Chemical Reviews · doi:10.1021/cr960437i · Cited by 1,018
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Goenka, S., Sant, V., & Sant, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.017 · Cited by 1,311
Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms
Ou, L., Song, B., Liang, H., Liu, J., Feng, X., Deng, B., Sun, T., & Shao, L. (2016) · Particle and Fibre Toxicology · doi:10.1186/s12989-016-0168-y · Cited by 803
Graphene-based materials for tissue engineering
Shin, S. R., Li, Y.-C., Jang, H. L., Khoshakhlagh, P., Akbari, M., Nasajpour, A., Zhang, Y. S., Tamayol, A., & Khademhosseini, A. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.03.007 · Cited by 721
New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide
Feng, L., Wu, L., & Qu, X. (2013) · Advanced Materials · doi:10.1002/adma.201203229 · Cited by 632
Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery
Panwar, N., Soehartono, A. M., Chan, K. K., Zeng, S., Xu, G., Qu, J., Coquet, P., Yong, K.-T., & Chen, X. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00099 · Cited by 555
Zhou, X., Zhang, Y., Wang, C., Wu, X., Yang, Y., Zheng, B., Wu, H., Guo, S., & Zhang, J. (2012) · ACS Nano · doi:10.1021/nn301629v · Cited by 537
Self-citationInteractions of graphene and graphene oxide with proteins and peptides
Zhang, Y., Wu, C., Guo, S., & Zhang, J. (2013) · Nanotechnology Reviews · doi:10.1515/ntrev-2012-0078 · Cited by 235
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Metadata
- Authors
- Ren, H., Wang, C., Zhang, J., Zhou, X., Xu, D., Zheng, J., Guo, S., & Zhang, J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-11-17
- Volume
- 4
- Issue
- 12
- Pages
- 7169-7174
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2078461802
- Cited by
- 175
- References
- 2
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- closed
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