The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Gold Nanorod−Photosensitizer Complex for Near-Infrared Fluorescence Imaging and Photodynamic/Photothermal Therapy In Vivo
Abstract
A gold nanorod (GNR)-photosensitizer complex was developed for noninvasive near-infrared fluorescence imaging and cancer therapy. We showed that (a) fluorescence emission and singlet oxygen generation by AlPcS(4) were quenched after complex formation with GNRs; (b) 4-fold greater intracellular uptake and better in vitro phototoxicity were observed in GNR-AlPcS(4)-treated cells than in free AlPcS(4)-treated cells; and (c) after intravenous injection of the GNR-AlPcS(4) complex, tumor sites were clearly identified on near-infrared fluorescence images as early as 1 h after injection. The tumor-to-background ratio increased over time and was 3.7 at 24 h; tumor growth reduced by 79% with photodynamic therapy (PDT) alone and by 95% with dual photothermal therapy (PTT) and PDT. This novel multifunctional nanomedicine may be useful for near-infrared fluorescence imaging and PTT/PDT in various cancers.
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Cites
Determination of subcutaneous tumor size in athymic (nude) mice
Tomayko, M. M., & Reynolds, C. P. (1989) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00300234 · Cited by 1,830
Cited by
Recent biomedical applications of gold nanoparticles: A review
Elahi, N., Kamali, M., & Baghersad, M. H. (2018) · Talanta · doi:10.1016/j.talanta.2018.02.088 · Cited by 1,174
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles
Abadeer, N. S., & Murphy, C. J. (2016) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.5b11232 · Cited by 919
Wang, S., Huang, P., Nie, L., Xing, R., Liu, D., Wang, Z., Lin, J., Chen, S., Niu, G., Lu, G., et al. (2013) · Advanced Materials · doi:10.1002/adma.201204623 · Cited by 503
Dong, Z., Feng, L., Hao, Y., Chen, M., Gao, M., Chao, Y., Zhao, H., Zhu, W., Liu, J., Liang, C., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11036 · Cited by 490
Metadata
- Authors
- Jang, B., Park, J.-Y., Tung, C.-H., Kim, I.-H., & Choi, Y.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-01-18
- Volume
- 5
- Issue
- 2
- Pages
- 1086-1094
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2329353330
- Cited by
- 750
- References
- 1
- FWCI
- 29.17
- Type
- journal article
- Language
- en
- Open access
- closed
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