The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Aptamer-Conjugated DNA Icosahedral Nanoparticles As a Carrier of Doxorubicin for Cancer Therapy
Abstract
DNA can be used to nanofabricate three-dimensional (3D) polyhedra. A variety of applications of 3D DNA assemblies have been proposed. Drug encasulation and intracellular delivery using DNA nanoparticles, however, have remained a challenge. Here, we create a distinct five-point-star motif and aptamer-conjugated six-point-star motif using well-used primer sequences to intermolecularly construct DNA icosahedra as a nanocarrier for doxorubicin. Aptamer-conjugated doxorubicin-intercalated DNA icosahedra (Doxo@Apt-DNA-icosa) show an efficient and specific internalization for killing epithelial cancer cells.
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Citations
Cites
Design and self-assembly of two-dimensional DNA crystals
Winfree, E., Liu, F., Wenzler, L. A., & Seeman, N. C. (1998) · Nature · doi:10.1038/28998 · Cited by 2,857
A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron
Shih, W. M., Quispe, J. D., & Joyce, G. F. (2004) · Nature · doi:10.1038/nature02307 · Cited by 989
Cited by
Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy
Meng, H.-M., Liu, H., Kuai, H., Peng, R., Mo, L., & Zhang, X.-B. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00645g · Cited by 608
DNA nanotechnology from the test tube to the cell
Chen, Y.-J., Groves, B., Muscat, R. A., & Seelig, G. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.195 · Cited by 594
DNA Functional Materials Assembled from Branched DNA: Design, Synthesis, and Applications
Dong, Y., Yao, C., Zhu, Y., Yang, L., Luo, D., & Yang, D. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00294 · Cited by 533
Wang, J., Zhu, G., You, M., Song, E., Shukoor, M. I., Zhang, K., Altman, M. B., Chen, Y., Zhu, Z., Huang, C. Z., et al. (2012) · ACS Nano · doi:10.1021/nn300694v · Cited by 357
DNA Nanoflowers for Multiplexed Cellular Imaging and Traceable Targeted Drug Delivery
Hu, R., Zhang, X., Zhao, Z., Zhu, G., Chen, T., Fu, T., & Tan, W. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201400323 · Cited by 337
Metadata
- Authors
- Chang, M., Yang, C.-S., & Huang, D.-M.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-07-08
- Volume
- 5
- Issue
- 8
- Pages
- 6156-6163
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1978158855
- Cited by
- 318
- References
- 2
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- closed
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