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Sensitivity Improved Surface Plasmon Resonance Biosensor for Cancer Biomarker Detection Based on Plasmonic Enhancement
Abstract
In this study, we report the development of a nanoparticle-enhanced biosensor by integrating both the nanoparticles and immunoassay sensing technologies into a phase interrogation surface plasmon resonance (SPR) system for detecting antigen at a concentration as low as the femtomolar range. Our work has demonstrated that the plasmonic field extension generated from the gold film to gold nanorod (GNR) has led to a drastic sensitivity enhancement. Antibody-functionalized sensing film, together with antibody-conjugated GNRs, was readily served as a plasmonic coupling partner that can be used as a powerful ultrasensitive sandwich immunoassay for cancer-related disease detection. Experimentally, it was found that the bioconjugated GNR labels enhance the tumor necrosis factor alpha (TNF-α) antigen signal with more than 40-fold increase compared to the traditional SPR biosensing technique. The underlying principle was analyzed by simulating the near-field coupling between the sensing film and the GNR. The results have shown that GNRs were readily served as promising amplification labels in SPR sensing technology.
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Cited by
Plasmon-enhanced optical sensors: a review
Li, M., Cushing, S. K., & Wu, N. (2015) · The Analyst · doi:10.1039/c4an01079e · Cited by 1,011
Emerging advances in nanomedicine with engineered gold nanostructures
Webb, J. A., & Bardhan, R. (2014) · Nanoscale · doi:10.1039/c3nr05112a · Cited by 324
Malhotra, B. D., & Ali, M. A. (2018) · Nanomaterials for Biosensors · doi:10.1016/b978-0-323-44923-6.00001-7 · Cited by 319
Bioanalytical Chemistry of Cytokines–a Review
Stenken, J. A., & Poschenrieder, A. J. (2015) · Analytica Chimica Acta · doi:10.1016/j.aca.2014.10.009 · Cited by 302
Philip, A., & Kumar, A. R. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214424 · Cited by 281
Metadata
- Authors
- Law, W.-C., Yong, K.-T., Baev, A., & Prasad, P. N.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-04-27
- Volume
- 5
- Issue
- 6
- Pages
- 4858-4864
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2319960298
- Cited by
- 289
- References
- 0
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Law, W.-C., Yong, K.-T., Baev, A., & Prasad, P. N. (2011). Sensitivity Improved Surface Plasmon Resonance Biosensor for Cancer Biomarker Detection Based on Plasmonic Enhancement. ACS Nano. https://doi.org/10.1021/nn2009485
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